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Abstract The heart-brain axis is a significant contributor to morbidity and mortality following ischemic injury. Pathological and psychological changes in the heart can lead to anxiety, cognitive impairment, and brain in...

Porcine circovirus-associated disease (PCVAD), caused by pathogenic porcine circovirus type 2 (PCV2), remains one of the most economically devastating diseases in the global swine industry, and the continued emergence an...

Proteolysis-targeting chimeras (PROTACs) have emerged as a promising therapeutic modality and now represent an important addition to the toolkit of medicinal chemists. Compared with conventional small-molecule inhibitors...

Mental health issues, including cognitive impairment, anxiety, and depression, have become a major global health challenge. Notably, conventional pharmacological treatments are often accompanied by adverse reactions. The...

The causes of cow mortality were studied depending on the level of homozygosity and genomic inbreeding of sires. Genomic data from 307 Holstein and Black-and-White bulls with 34,280 daughters were used. To calculate the ...

Abstract The precise separation of chromosomes during meiosis is critical for maintaining genetic stability, a process intricately orchestrated by Shugoshin (SGO) proteins. SGO plays a pivotal role in protecting the cent...

Abstract Inequalities in social networks arise from linking mechanisms, such as preferential attachment (connecting to popular nodes), homophily (connecting to similar others), and triadic closure (connecting through mut...

Background/Aims: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy characterized by high invasiveness. The current study aimed to evaluate the role of miR-3678-3p in ESCC and its potential mechan...

Abstract The explosion of patient data, the demand for real-time insights, and the critical importance of data security drive healthcare innovation. Medical Internet of Things (IoMT) offers a promising solution, connecti...

Abstract Background Porcine circovirus type 2 (PCV2) and porcine circovirus type 3 (PCV3) have emerged as significant pathogens jeopardizing the swine industry in China in recent years, and caused substantial economic lo...

BackgroundAtaxia-telangiectasia (A-T) is a rare autosomal recessive disorder caused by pathogenic variants in the ATM gene and characterized by genomic instability, immunodeficiency, and a markedly increased risk of canc...

IntroductionOSMR encodes oncostatin M receptor beta (OSMRβ), a cell surface receptor of the gp130 family that binds OSM and IL-31, and is highly expressed on fibroblasts. The gp130 family comprises signaling proteins, m...

Background: The estimated glomerular filtration rate (eGFR), derived from serum creatinine (eGFRcr) or cystatin C (eGFRcys), is crucial for assessing kidney function and predicting health outcomes. While eGFRcr is known ...

Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologo...

Abstract The advancement of sustained-release drug delivery systems is profoundly reshaping the medicinal applications. This study highlights a novel approach to developing sustained-release esterase responsive drug deli...