Buscar recursos académicos

IntroductionPediatric hemophagocytic lymphohistiocytosis (pHLH) is a life-threatening condition characterized by aberrant immunopathology and systemic manifestations. The HLH-2004 protocol prioritizes urgent immunosuppre...

BackgroundTranscriptome−wide association study (TWAS) contributes to discovering novel susceptibility genes related to diseases. Single-cell RNA sequencing (scRNA-seq) has been extensively applied to characterize cellu...

The significant impact of Chlamydia trachomatis(Ct) infections worldwide highlights the need to develop a prophylactic vaccine that elicits effective immunity and protects the host from the immunopathological effects of ...

IntroductionFc-mediated antibody effector functions play key roles in both antiviral immunity and immunopathology in COVID-19. While antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotox...

Multiple Sclerosis (MS) is a chronic neuroinflammatory autoimmune characterized by inflammation-induced lesion formation after immune cell infiltration into the central nervous system. T cells play an intriguing role in...

IntroductionIn co-endemic regions, hosts are concurrently infected by related apicomplexan hemoparasites, Plasmodium and the zoonotic pathogen Babesia. This study investigates how Plasmodium berghei XAT-Babesia rodhaini ...

Genome-wide association studies have identified members of the CARD11/MALT1/BCL10 (CBM) complex as susceptibility loci for common allergic disorders, while carriers with rare loss-of-function (LOF) variants in MALT1 or C...

BackgroundThymoma, a neoplasm of the thymus, leads to hypogammaglobulinemia in ∼10% of affected patients, resulting in Good syndrome that frequently coexists with autoimmunity and mucosal candidiasis. Thymomas lose the...

The interplay between thyroid hormone action and the immune system has been established in physiological and pathological settings. However, their connection is complex and still not completely understood. The thyroid ho...