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73 resultados encontrados.

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Monitorization of Immunosuppressive Therapy in Renal Transplant Recipients
Artículo
Acceso abierto Artículo DOAJ
Alper KIRKPANTUR et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Despite improved short-term outcome in patient and graft survival in renal transplantation, no major improvements have been detected in long-term survival. The success of solid organ transplantation lies in the administe...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
Immunosuppressive Agents in the Treatment of Membranoproliferative Glomerulonephritis
Artículo
Acceso abierto Artículo DOAJ
Tülin Akagün et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
INTRODUCTION: Treatment of membranoproliferative glomerulonephritis (MPGN) is often unrewarding with approximately 60% of patients progressing to end-stage renal failure within 10 years. In our study, we compared the eff...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
Steroid Therapy in Initial Treatment of Idiopathic Membranous Nephropathy
Artículo
Acceso abierto Artículo DOAJ
Savaş ÖZTÜRK et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Background: The introduction of renin angiotensin system blockers (RASB) might challenge the previous results of immunosuppressive therapies in idiopathic membranous nephropathy (IMN). We investigated the effectiveness o...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
Case Report: Atypical pattern of pathologic response in cutaneous transdifferentiated melanoma with rhabdomyoblastic differentiation following neoadjuvant therapy
Artículo
Acceso abierto Artículo DOAJ
Isabela Paulino Serur et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
Transdifferentiated melanoma is a rare variant of melanoma characterized by phenotypic plasticity, loss of conventional melanocytic markers, and acquisition of features from other tissue lineages, often associated with a...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Open Access
Does chronic corticosteroid therapy affect the concentration of 25(OH)D 3 in the serum of patients with pemphigus?
Artículo
Material complementario disponible Artículo DOAJ
Marlena Chmielnicka et al · Termedia Publishing House · 2014 · ISSN 0033-2526
Introduction . Pemphigus is an autoimmune blistering disease, characterized by the presence of autoantibodies directed against desmoglein. It is a severe and potentially life-threatening skin disease, requiring prolonged...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Nano-bionic bacteria armed adoptive macrophage therapy against bladder cancer
Artículo
Acceso abierto Artículo DOAJ
Peng Wang et al · Elsevier · 2026 · ISSN 2590-0064
Bladder cancer is a highly malignant tumor with limited treatment options. Although adoptive cell therapy has shown promise in oncology, its efficacy is often constrained by poor intrinsic antitumor activity and a highly...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Biology (General)Idioma eng
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Open Access
Targeting tumor-associated macrophages through phytochemicals: a promising strategy for cold tumor therapy
Artículo
Material complementario disponible Artículo DOAJ
Tian Shue et al · BMC · 2026 · ISSN 1749-8546
Abstract Immunotherapy serves as the fourth modality for cancer treatment, following surgery, radiotherapy, and chemotherapy. However, its efficacy remains inconsistent due to the heterogeneity of the tumor microenvironm...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng
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Tumor microenvironment responsive nano-immunoregulator for precision cancer photodynamic immunotherapy
Artículo
Acceso abierto Artículo DOAJ
Xiaowei Chang et al · Elsevier · 2026 · ISSN 2590-0064
Spatiotemporally controlled reactive oxygen species (ROS) generation remains pivotal for advancing photodynamic immunotherapy. Herein, we present tumor microenvironment (TME)-responsive nano-immunoregulator featuring a C...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Biology (General)Idioma eng
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Open Access
Recurrent cerebral venous thrombosis associated with IgG4-related hypertrophic pachymeningitis: Case report and literature review
Artículo
Acceso abierto Artículo DOAJ
Yanshu Wang et al · BMC · 2026 · ISSN 1471-2377
Abstract IgG4-related disease (IgG4-RD) is a systemic inflammatory condition marked by tissue infiltration of IgG4-positive plasma cells, often resulting in fibrosis. While IgG4-RD commonly affects organs such as the pan...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Open Access
Termination of Hemodialysis Treatment on the 5th Month of Mycophenolate Mofetil in Type 4 Lupus Nephritis with Serious Renal Failure: A Case Report
Artículo
Acceso abierto Artículo DOAJ
Dilek TORUN et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Systemic lupus erythematosus (SLE) is a chronic, occasionally life-threatening, multisystem disorder, and renal involvement is one of the most common and most serious complications of SLE. Among the various histological ...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
BOLUS METHYLPREDNISOLONE AS INDUCTION THERAPY FOR IMMUNOSUPPRESSION IN RENAL TRANSPLANT RECIPIENTS
Artículo
Acceso abierto Artículo DOAJ
Oktay OYMAK et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Studies to prevent organ rejection in renal transplant patients are continuing. Improvement in HLA-matching and efficiency of immunosuppressive drugs are the most important factors. In this study, effects of single or th...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
Evaluation of Adherence to Immunosuppressive Treatment with Different Methods in Kidney Transplant Recipients
Artículo
Acceso abierto Artículo DOAJ
Yaprak SARIGÖL ORDİN et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
OBJECTIVE: This study was conducted to compare the medication adherence levels of kidney transplant recipients using different measures. MATERIAL and METHODS: This descriptive, cross-sectional study was carried out wi...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
First-in-human use of recombinant IL-7 to potentiate antigen-specific T cell therapy: a single patient case study
Artículo
Acceso abierto Artículo DOAJ
Linghua Wang et al · BMJ Publishing Group · 2026 · ISSN 2051-1426
Clinical trials of adoptive cellular therapy demonstrate that a key characteristic associated with durable responses is in vivo expansion and persistence of transferred T cells. Strategies to develop a less differentiate...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Open Access
Neutrophil extracellular traps in the tumor microenvironment, metastasis, therapy, and beyond: advances, challenges, and perspectives
Artículo
Acceso abierto Artículo DOAJ
Jingwen He et al · BMC · 2026 · ISSN 1756-8722
Abstract Neutrophil extracellular traps (NETs), the DNA-protein structures released by neutrophils within the tumor microenvironment (TME), play a role in cancer that extends far beyond their traditional antimicrobial fu...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBibG9vZCBhbmQgYmxvb2QtZm9ybWluZyBvcmdhbnM~; TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHIdioma eng
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Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma
Artículo
Acceso abierto Artículo DOAJ
Tao Wang et al · Wiley · 2026 · ISSN 2198-3844
ABSTRACT Mutation‐intolerant genes (MIGs), which are constrained in tumors yet variable in normal tissues, are critical for cancer survival. Herein, we developed miDriver, a computational framework using pancancer‐no...
LCC TENDOlNjaWVuY2U~Idioma eng
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Open Access
Balancing analgesia and immunity: revisiting the immune consequences of opioid therapy
Artículo
Acceso abierto Artículo DOAJ
Lucia Daiana Voiculescu et al · Open Exploration Publishing Inc · 2026 · ISSN 2768-6655
Opioids remain central to managing moderate to severe pain, yet they also produce significant and often under-recognized effects on the immune system. In this narrative review, we synthesize evidence from 1994 to 2025 ac...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Open Access
Interstitial Pneumonitis After Everolimus Therapy for Renal Cell Carcinoma
Artículo
Acceso abierto Artículo DOAJ
Emre URHAN et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Everolimus is an immunosuppressive agent belonging to the mTOR inhibitors group, used in solid organ transplantation and renal cell carcinomas. The use of inhibitors of the mTOR group in renal carcinomas is associated wi...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Open Access
Unusual Case Presentations of Wegener’s Granulomatosis
Artículo
Acceso abierto Artículo DOAJ
Zehra EREN et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Wegener’s granulomatosis (WG) is an uncommon condition characterized by necrotizing granulomatosis of the upper and lower respiratory tract and glomerulonephritis. Clinical symptoms and organ involvement of the disease...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part II. Systemic treatment and new therapeutic methods
Artículo
Acceso abierto Artículo DOAJ
Roman Nowicki et al · Termedia Publishing House · 2019 · ISSN 0033-2526
The treatment goal in atopic dermatitis is eliminating clinical symptoms of the disease, preventing exacerbations and complications, as well as improving patients’ quality of life. In cases of severe atopic dermatitis ...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Open Access
HMGN2 deficiency drives DLBCL progression through impaired R-loop formation and PI3K-AKT hyperactivation
Artículo
Material complementario disponible Artículo DOAJ
Jinman Zhong et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Diffuse large B-cell lymphoma (DLBCL) exhibits significant heterogeneity, with therapy resistance in Activated B-cell-like (ABC) and relapsed Germinal Center B-cell-like (GCB) subtypes being major cha...
LCC LCC:MedicineIdioma eng
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Identification and external validation of a prognostic signature based on myeloid-derived suppressor cell-related lncRNAs for hepatocellular carcinoma
Artículo
Material complementario disponible Artículo DOAJ
Tong Mu et al · BMC · 2026 · ISSN 1601-5223
Abstract Background Hepatocellular carcinoma (HCC) outcomes remain suboptimal. Myeloid-derived suppressor cells (MDSCs) exhibit notable immunosuppressive and pro-tumorigenic properties. However, the relationship with HCC...
LCC LCC:GeneticsIdioma eng
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Immunostimulatory photochemotherapeutic nanocapsule for enhanced colon cancer treatment
Artículo
Acceso abierto Artículo DOAJ
Liu Jie et al · Wiley · 2021 · ISSN 2192-8614
Immunotherapy has made great progress in recent years while most cancer patients cannot benefit from it. Photochemotherapy combination strategy holds great promise for developing novel immunotherapy for the patients bear...
LCC TENDOlBoeXNpY3M~Idioma eng
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Open Access
Photodynamic priming with triple-receptor targeted nanoconjugates that trigger T cell-mediated immune responses in a 3D in vitro heterocellular model of pancreatic cancer
Artículo
Acceso abierto Artículo DOAJ
De Silva Pushpamali et al · Wiley · 2021 · ISSN 2192-8614
Photodynamic priming (PDP), a collateral effect of photodynamic therapy, can transiently alter the tumor microenvironment (TME) beyond the cytotoxic zone. Studies have demonstrated that PDP increases tumor permeability a...
LCC TENDOlBoeXNpY3M~Idioma eng
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Special papers Diagnostic and therapeutic advances in dermatomyositis
Artículo
Acceso abierto Artículo DOAJ
Dominik Samotij et al · Termedia Publishing House · 2015 · ISSN 0033-2526
Dermatomyositis (DM) is one of the so-called idiopathic inflammatory myopathies (IIM). Dermatomyositis is an autoimmune disorder characterized by the presence of cutaneous lesions and/or symptoms of muscle involvement wi...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Open Access