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BackgroundThe use of antibiotics may influence the efficacy and toxicity of immune checkpoint inhibitors (ICIs) by altering the gut microbiota. However, current evidence on the link between antibiotic use and immune-rela...

BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...

BackgroundThe toxicities associated with immune checkpoint inhibitors (ICIs) can affect nearly all organ systems. Although previous studies have examined specific types of immune-related adverse events (irAEs) associated...

OBJECTIVE: Mammalian target of rapamycin (mTOR) inhibitors are among the immunosuppressive drugs used in renal transplantation. The aim of this study was to reveal our experiences in conversion from calcineurin inhibitor...

ObjectivesTo conduct a scoping review mapping the extent, nature, and consistency of available evidence regarding the effects of sodium–glucose cotransporter-2 (SGLT2) inhibitors on kidney function, proteinuria, kidney...

Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPis) are the standard of care for primary ovarian cancer (OC), yet adverse events (AEs) frequently necessitate dose modifications. The prognostic impact of ...

Abstract Background Current guidelines recommend baseline insulin as the standard treatment for most people hospitalised with type 2 diabetes (PWT2D). However, they generally discourage the use of sodium–glucose cotran...

Psoriasis and psoriatic arthritis are chronic immune-mediated disorders associated with substantially impaired quality of life and comorbidities. Janus kinase (JAK) inhibitors have recently emerged as highly efficient th...

A structurally diverse dataset of 530 polo-like kinase-1 (PLK1) inhibitors is compiledfrom the ChEMBL database and studied by means of a conformation-independent quantitativestructure-activity relationship (QSAR) approac...

ObjectiveTo systematically evaluate the incidence of tuberculosis (TB) in cancer patients treated with immune checkpoint inhibitors (ICIs) and compare the risk of TB between ICI-treated and non-ICI-treated cancer patient...

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that plays a pivotal role in DNA repair and the maintenance of genomic stability. The discovery of synthetic lethality in tumors with homologous recombination...

We report here the virtual screening design, synthesis and activity of eight new inhibitors of SphK1. For this study we used a pre-trained Graph Convolutional Network (GCN) combined with docking calculations. This explor...

ObjectiveThe impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) on postoperative atrial fibrillation (AF) recurrence and cardiac function in patients with AF and heart failure (HF) undergoing catheter ablation ...

Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....

Materias / palabras clave: cancer; immune checkpoint inhibitors; incidence; morbidity risk; tuberculosis

Materias / palabras clave: cancer therapy; immunogenic cell death; protein kinase inhibitors; signaling pathway; targeted therapy

Materias / palabras clave: advanced breast cancer; CDK4/6 inhibitors; ctDNA; endocrine therapy; overall survival; treatment sequencing

Among the most prevalent yet poorly understood female health issues is uterine leiomyomas. In order to preserve fertility and avoid or delay surgical intervention, medical treatments are typically considered first-line. ...

Abstract The abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of complement C9 into the membrane is the final step and kinetic...

The effects of different concentrations of biological nitrification inhibitors(methyl p-hydroxyphenylpropionate(MHPP), syringic acid(SA)) and chemical nitrification inhibitors(dicyanediamine(DCD), 3, 4- dimethyl-1H-pyraz...

The result of the recent study revealed that the host kind (Artificial diet, Date and Fig) affect the Susceptibility of different insect stages of Fig moth Ephestia caute/la (Walk.) and CmTant moth Ephestia ca/ide/la ...

Abstract Immune checkpoint inhibitors (ICI) have transformed the treatment of metastatic malignancies, yet only 20–40% of unselected patients benefit. Peripheral blood could offer a minimally invasive and dynamic sourc...

Abstract Glucocorticoid (GC) use in rheumatoid arthritis (RA) remains concerning due to adverse effects. Janus kinase inhibitors (JAKi) may enable GC reduction or discontinuation. This study examined factors associated w...

Heat-shock protein 90 (Hsp90) inhibitors exhibit activity against human cancers. We evaluated a series of new, oral bioavailable, chemically diverse Hsp90 inhibitors (PU-H71, AUY922, BIIB021, NVP-BEP800) against Kaposi s...