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BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...

Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPis) are the standard of care for primary ovarian cancer (OC), yet adverse events (AEs) frequently necessitate dose modifications. The prognostic impact of ...

Abstract Background Current guidelines recommend baseline insulin as the standard treatment for most people hospitalised with type 2 diabetes (PWT2D). However, they generally discourage the use of sodium–glucose cotran...

Psoriasis and psoriatic arthritis are chronic immune-mediated disorders associated with substantially impaired quality of life and comorbidities. Janus kinase (JAK) inhibitors have recently emerged as highly efficient th...

A structurally diverse dataset of 530 polo-like kinase-1 (PLK1) inhibitors is compiledfrom the ChEMBL database and studied by means of a conformation-independent quantitativestructure-activity relationship (QSAR) approac...

ObjectiveTo systematically evaluate the incidence of tuberculosis (TB) in cancer patients treated with immune checkpoint inhibitors (ICIs) and compare the risk of TB between ICI-treated and non-ICI-treated cancer patient...

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that plays a pivotal role in DNA repair and the maintenance of genomic stability. The discovery of synthetic lethality in tumors with homologous recombination...

We report here the virtual screening design, synthesis and activity of eight new inhibitors of SphK1. For this study we used a pre-trained Graph Convolutional Network (GCN) combined with docking calculations. This explor...

ObjectiveThe impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) on postoperative atrial fibrillation (AF) recurrence and cardiac function in patients with AF and heart failure (HF) undergoing catheter ablation ...

Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....

Materias / palabras clave: cancer; immune checkpoint inhibitors; incidence; morbidity risk; tuberculosis

Materias / palabras clave: advanced breast cancer; CDK4/6 inhibitors; ctDNA; endocrine therapy; overall survival; treatment sequencing

Diferentes classes de proteínas são comuns em sementes de leguminosas, incluindo inibidores de tripsina e proteínas hemaglutinantes, as quais atuam sobre enzimas proteolíticas e sobre carboidratos da superfície celu...

The effects of different concentrations of biological nitrification inhibitors(methyl p-hydroxyphenylpropionate(MHPP), syringic acid(SA)) and chemical nitrification inhibitors(dicyanediamine(DCD), 3, 4- dimethyl-1H-pyraz...

Abstract Immune checkpoint inhibitors (ICI) have transformed the treatment of metastatic malignancies, yet only 20–40% of unselected patients benefit. Peripheral blood could offer a minimally invasive and dynamic sourc...

Heat-shock protein 90 (Hsp90) inhibitors exhibit activity against human cancers. We evaluated a series of new, oral bioavailable, chemically diverse Hsp90 inhibitors (PU-H71, AUY922, BIIB021, NVP-BEP800) against Kaposi s...

Leishmaniasis is a public health disease that requires the development of more effective treatments and the identification of novel molecular targets. Since blocking the PI3K/AKT pathway has been successfully studied as ...

Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors hav...

Background: Leukemia is the most common childhood cancer. While tyrosine kinase inhibitors (TKIs) improve survival, they impose substantial economic burdens. This study evaluates the impact of China’s National Volume-B...

FtsZ is a tubulin homolog in bacteria. It forms a Z-ring to recruit other proteins in the process of cell division through its GTPase activity. Amino acid sequence of FtsZ was obtained from uniprot database and used for ...

Abstract/Resumen: Trypanosoma cruzi and Plasmodium falciparum are the etiologic agents of Chagas disease and Malaria, respectively. Cysteine proteases play key roles in the pathogenesis and survival of these parasites, s...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction, making acetylcholinesterase (AChE) a key therapeutic target. Although Garcinia kola has been widely reported ...

Leguminous seeds (Fabaceae) have a high content of inhibitors of which serine protease inhibitors are the most widely studied. However, there are only a few studies related to the investigation of these proteins in tree ...

Abstract Background Axial spondyloarthritis (axSpA) is commonly treated with tumor necrosis factor-alpha (TNF-α) inhibitors, which show good efficacy but may cause adverse effects or lose effectiveness over time. Interl...