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BackgroundAs populations age rapidly, community-based care is crucial to support aging-in-place. Yet, few models successfully integrate health promotion, social engagement and care coordination at scale. Singapore’s Ac...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...

BackgroundEarly detection of diabetic retinopathy (DR) remains challenging in primary care, where access to ophthalmic screening is limited. We developed and validated a prediction model using routinely collected health ...

Abstract Purpose This study aimed to investigate sleep patterns in children with severe medical complexity (CMC) eligible for pediatric palliative care (PPC) and to evaluate the specific impact of these patterns on their...

BackgroundThis study aimed to evaluate whether Mycoplasma pneumoniae resistance gene detection can independently guide antibiotic therapy for Mycoplasma pneumoniae pneumonia in children and to identify key predictors for...

Key Points. Approximately half of people on maintenance hemodialysis exhibited impairment on a standardized, performance-based assessment of functional cognition. The functional cognitive test correlated strongly with a ...

Background: Despite high cure rates in pediatric B-cell acute lymphoblastic leukemia (B-ALL), relapse remains a major challenge. Current risk stratification systems fail to identify a subset of occult high-risk (HR) pati...

ABSTRACT Background and Aims In‐hospital death and recovery are competing risks in COVID‐19 patients, complicating prognosis. While international prognostic scores exist, their reliance on complex biomarkers limits t...

Background: Previous studies have demonstrated that thoracic radiotherapy (TRT) following first-line chemoimmunotherapy improves survival in extensive-stage small cell lung cancer (ES-SCLC). However, its efficacy and saf...

Background In multiple sclerosis (MS), delays in initiation of disease-modifying therapy (DMT) are associated with worse clinical outcomes. Methods This single-center retrospective chart review study included treatment-n...

Objective: Evaluate whether implementation of an academic trauma team and a dedicated orthopaedic trauma room (DOTR) reduces surgical delay and improves efficiency in hip fracture management at a Level III trauma center....

Abstract Background Lung cancer surgery in low- and middle-income countries (LMICs) is frequently challenged by late-stage presentation, high comorbidity burden, and limited healthcare resources. Although video-assisted ...

Abstract Background Empiric antimicrobial selection in orthotopic heart transplantation (OHT) is critically important as post-operative infections are a significant cause of morbidity and mortality. While variability of ...

IntroductionSchnitzler syndrome (SchS) is a rare, late-onset, acquired autoinflammatory disorder characterized by recurrent urticarial lesions, monoclonal gammopathy and systemic inflammation. Although interleukin-1 (IL-...

Abstract Introduction Omadacycline is indicated for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. With limited real-world data, we report the clinical exp...

Background & Aims: Atezolizumab/bevacizumab (A/B) and durvalumab ± tremelimumab (DT/D) are preferred first-line regimens for the treatment of hepatocellular carcinoma (HCC). Although both therapies share an anti-PD-...

IntroductionAssisted reproductive technology (ART) practice varies widely across centers and evolves rapidly, often outpacing the generation of randomized evidence. OPERA (Observational ProjEct for a Research database fo...

Purpose — Single motherhood is widely associated with poorer child outcomes, yet it remains unclear whether these disadvantages stem from family structure itself or from the economic shocks that accompany it. This dist...

Chronic pain affects hundreds of millions worldwide, yet current treatments—from NSAIDs to opioids—fall short and bring unwanted side effects. Neuroinflammation drives bidirectional glial-neuronal communication, a co...

Abstract Background Diabetes is a leading cause of mortality globally and ranks as the eighth leading cause of death in the United States. Affecting approximately 8.9% of Americans, diabetes imposes a substantial public ...

BackgroundMeteorological factors are among the key extrinsic triggers for the onset and exacerbation of cardiovascular and cerebrovascular diseases (CVD). Against the backdrop of sustained global warming, elucidating the...

IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imagi...

BackgroundSubarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms is a severe stroke subtype with a high mortality rate. Statins, noted for cholesterol-independent benefits, are being studied as potential trea...