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Se cuantificaron y compararon los melanomacrófagos (MM) y la actividad de la enzima Glutatión S-Transferasa (GST) en hígados de ejemplares adultos de Leptodactylus chaquensis (Anura, Leptodactylidae) colectados en un ...

Se realizó un estudio retrospectivo, de tipo descriptivo y de corte transversal, de pacientes que acudieron a la consulta a un Servicio de Dermatología de la ciudad de La Plata. Fueron revisadas las historias clínicas...

The aim of this study was to explore the acute effects of high-intensity interval training (HIIT) on the microvascular circulation and vascular tumor microenvironment (TME) in a patient with uveal melanoma (UM). Addition...

BackgroundAdjuvant immune checkpoint inhibitors (ICI) have improved survival in stage III cutaneous melanoma, yet many patients do not benefit. The tumor microenvironment is pivotal for durable responses; defining cellul...

Transdifferentiated melanoma is a rare variant of melanoma characterized by phenotypic plasticity, loss of conventional melanocytic markers, and acquisition of features from other tissue lineages, often associated with a...

Proton beam therapy is a globe preserving treatment method of choroidal melanoma. It is considered to be less harmful for the tissues around the tumour but the complications such as radiation retinopathy and neuropathy o...

Abstract Background Immunotherapy based on anti-PD1 inhibitors has significantly improved survival in advanced melanoma. However, a significant proportion of patients do not benefit, and predicting response to immunother...

Aims This study aimed to explore the prognostic and immune-related associations of adiponectin-related genes in melanoma.Methods Single nucleotide polymorphism (SNP) and transcriptomic data from the Integrative Epidemiol...

IntroductionSkin cancer, including basal cell carcinoma, squamous cell carcinoma, and melanoma, is one of the most common cancers worldwide. Matrix metalloproteinases are zinc-dependent proteolytic enzymes that play a cr...

Abstract Background The overall incidence of pituitary apoplexy among patients with pituitary adenoma ranges from 0.6% to 7.0%, although many cases likely go undiagnosed. Several precipitating factors have been identifie...

Background: Melanoma represents a highly aggressive and metastatic form of malignant skin cancer. that remains challenging to treat clinically. Tumor cells often reprogram nicotinamide adenine dinucleotide (NAD⁺) metab...

Abstract Melanomas of the female genital tract may occur in the vulva, the vagina, the ovary or the cervix.Pregnancy has been considered an aggravating factor in the evolution and prognosis of melanoma. A 35-year-old fem...

Abstract Background Uveal melanoma (UM) is a rare disease, but the most common intraocular malignancy in adults, with incidence rates in Europe ranging from 1.3 to 8.6 cases per million annually. Although local tumor con...

Abstract Background Adoptive cell therapy with tumour-infiltrating lymphocytes has been recognised as a safe and effective treatment for patients with advanced melanoma. Whether such a novel intervention is cost-effectiv...

Materias / palabras clave: cutaneous melanoma; vitamin d receptor; polymorphism; meta-analysis

Introduction Mucosal melanoma (MM) carries a high risk of postoperative relapse and poorer survival than cutaneous disease. Prospective data from China support adjuvant temozolomide–cisplatin (TMZ/DDP) in resected MM, ...

Abstract Immunotherapy has transformed melanoma treatment, yet only a subset of patients benefit and clinically effective biomarkers remain limited. Here, we report a comprehensive analysis evaluating CD27 as a predictiv...

B16F10 cells are a murine melanoma cell line characterized by high metastatic potential and resistance to various treatments. Studies indicate that cancer can cause significant alterations in the heart's electrical condu...

Abstract Despite advances in therapy, survival rates for metastatic melanoma remain low. Drug-tolerant persister cells (persisters) can facilitate cancer recurrence, yet their characteristics and vulnerabilities differ a...

Abstract Since the first report in 1972, several studies have documented an association between Parkinson’s disease (PD) and melanoma. Up to 20-fold increased risk of melanoma was reported in PD patients, while a perso...

Con el objetivo de evaluar la viabilidad del trasplante de un melanoma canino en ratones inmunodeficientes, 3 ratones N:NIH (S)-Fox1 nu libres de patógenos específicos de 6 semanas de edad se trasplantaron por vía sub...

Trabajo Final Integrador de Ingeniería En este trabajo se desarrolló una herramienta de asistencia diagnóstica, basada en procesamiento de imágenes dermatológicas e inteligencia artificial que asiste al dermatólogo...