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IntroductionPediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early cognitive and psychosocial impact, and difficulties with long-term treatment adherence. T...

IntroductionThe aim of the study is to investigate the association between fatigue, cognitive impairment, and overall QoL in individuals with Multiple Sclerosis (MS).MethodsFifty-one patients with MS with a confirmed dia...

ABSTRACT Background and Aims Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and neurodegeneration. Conventional MRI techniques lack specificity for ...

ABSTRACT Background Multiple sclerosis (MS) is the most prevalent immune‐mediated neurodegenerative disease affecting the central nervous system. Ocrelizumab, a humanized anti‐CD20 monoclonal antibody, has demonstrat...

BackgroundQuality of life (QoL) in multiple sclerosis (MS) is multifactorial, reflecting the combined effects of physical disability, cognitive impairment, and depressive symptoms. While physical disability is a key dete...

IntroductionMultiple sclerosis (MS) shows marked female predominance, particularly among women of childbearing age (WCBA, 15–49 years), yet their specific disease burden remains under characterized. Using Global Burden...

BackgroundMS and NMOSD are chronic demyelinating diseases related to demyelinating attacks on the central nervous system which limit quality of life and predisposes patients to developing anxiety and depression which, in...

Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) signaling promotes disease-associated microglia (DAM) and phagocytosis in neurodegenerative diseases. Traditional anti-TREM2 agonist antibodies ...

Background In multiple sclerosis (MS), delays in initiation of disease-modifying therapy (DMT) are associated with worse clinical outcomes. Methods This single-center retrospective chart review study included treatment-n...

Background: In multiple sclerosis (MS), chronic “smoldering” lesions are driven by microglial activation, which promotes demyelination and disease progression. However, microglia exhibit a functional dichotomy by per...

Background There is limited evidence on the feasibility of remotely delivered exercise interventions for English-speaking Hispanics/Latinos with MS. Objectives To evaluate the feasibility and exploratory efficacy of a re...

The application of Chimeric Antigen Receptor T-cell (CAR-T), CAR-engineered regulatory T cell (CAR-Treg) and hematopoietic stem cell (HSC) therapies has grown in recent years, driven by an increasing demand for robust, a...

Background and ObjectiveDifferentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti–aquaporin-4 immunoglobulin...

Abstract Fibrosis arises from aberrant tissue repair in systemic sclerosis and is characterized by progressive stiffening across multiple tissues, including tendons. How altered tissue mechanics sustain fibrotic remodeli...

Abstract Background Autoimmune conditions are common in women of reproductive age. They are associated with an increased risk of adverse pregnancy outcomes; whether this is causal is unclear. Our aim was to explore the c...

Ferroptosis is a form of regulated cell death driven by iron-dependent lipid peroxidation, which plays a pivotal role in regulating the inflammatory-immune microenvironment of central nervous system (CNS) diseases. Mount...

Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...

Abstract Autoimmune diseases (AIDs) result from intricate interactions among genetic, environmental and immune factors, with emerging evidence underscoring the role of the central nervous system (CNS) in their pathogenes...

Lucie Bartova,1 Mara Lisa Beuster,2 Bruno Bonetti,3 Giuseppe Maina,4,5 Pedro Morgado,6 Johan Nyberg7 1Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, and Comprehensive Center for Clin...

Abstract Introduction Valacyclovir is the only treatment option during pregnancy which has been demonstrated to be effective within a randomized clinical trial for prevention of transplacental cytomegalovirus (CMV) tran...

Small sample sizes in preclinical research limit the extraction of reliable knowledge and hinder translational progress. We propose genESOM, a generative artificial intelligence method based on emergent self‑organizing...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. Th...

Abstract Abnormal astrocytes activation contributes to disease progression in multiple sclerosis (MS), yet the regulatory mechanisms are not fully understood. Here, we found that repulsive guidance molecule a (RGMa) was ...

Abstract Background Obesity has emerged as a major global health issue, affecting multiple organ systems. Within the central nervous system obesity causes a series of disruptions that can significantly affect neurologica...