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Increase in the relative risk of development of secondary malignancy in patients with rheumatoid arthritis (RA) have been demonstrated, possibly either due to underlying immunological disorders, or to cytotoxic drugs use...

Multiple myeloma (MM) is best understood as a dynamically evolving genomic ecosystem shaped by inherited susceptibility, early oncogenic events, and continuous selective pressures. We propose an evolutionary genomics fra...

Kidney injury is a common complication of symptomatic multiple myeloma (MM) and has an impact on the survival of patients. Cast nephropathy (myeloma kidney) is the most common cause of severe kidney dysfunction in MM. Hy...

Multiple myeloma (MM) is a multisystem disorder where renal involvement worsens the prognosis significantly. Herein, we present two cases with an atypical clinical presentation. A 38-year-old female presented to our c...

Bone marrow hemodilution could compromise next generation flow cytometry based measurable residual disease evaluation in multiple myeloma and may cause false negative results. This review summarizes definitions, markers,...

Abstract DIS3, a key nuclear RNA-degrading enzyme, is essential for immunoglobulin class switch recombination (CSR), promoting activation-induced cytidine deaminase (AID) activity on both DNA strands to induce double-str...

Abstract Despite advances in therapy, multiple myeloma (MM) largely remains incurable, emphasizing the need for new strategies to overcome drug resistance. Ferroptosis is an iron-dependent cell death pathway that may pre...

Abstract Background Detection of free light chains (fLC) in animals relies on protein electrophoresis or the Bence‐Jones protein test on urine. Objective To describe the detection of both serum fLC (sfLC) and urine fLC...

In this plain language podcast, highlights from the 67th American Society of Hematology Annual Meeting and Exposition (ASH 2025) are discussed, with insights from the perspective of an expert patient and physician experi...

Multiple myeloma is a plasma cell neoplasm that accounts for approximately 1% of all tumors in dogs and is more commonly diagnosed in elderly animals. Clinical signs are generally nonspecific and may include bone pain, l...

Financial toxicity, the material, psychological and social burden associated with the cost of cancer care, can meaningfully affect patients preparing for autologous stem cell transplant (ASCT) for multiple myeloma. This ...

ABSTRACT Monoclonal gammopathy (MG) is rare in dogs and multiple myeloma (MM) is its main cause. This study reports the case of a female dog which presented MG associated with a MM and consequent blood hyperviscosity syn...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

Focal segmental glomerulosclerosis is a non-inflammatory glomerulopathy associated with nephrotic syndrome and end-stage renal failure. Focal segmental glomerulosclerosis related to plasma cell disorder is not common. A ...

Light chain deposition disease (LCDD) is a rare disease and the most common subtype of monoclonal immunglobulin deposition disease (MCDD). The most commonly affected organ is the kidney, characterized by nodular glomerul...

Abstract Background Retrospective research recently identified a possible relationship between duration of surgery and outcome in severely affected dogs treated surgically for acute thoracolumbar intervertebral disk hern...

Background: Hematological malignancies, encompassing leukemia, lymphoma, and myeloma, constitute a significant cause of morbidity and mortality. Early diagnosis plays a pivotal role in improving prognosis and facilitatin...

IntroductionIncreased risk of infections in patients with hematological malignancies (HM) is a growing concern. Immunoglobulin-replacement therapy (IgRT) is used to reduce infection risk in patients who develop secondary...

Plasmapheresis is a method of cleaning the high molecular weight solutes such as immune complexes, protein-bound toxins, autoantibodies, cryoglobulins, myeloma light chains, and endotoxins from the extracorporeal blood p...

ObjectivesThe primary objective of this project was to explore the challenges related to the implementation of patient-reported outcome measures (PROMs) in myeloma, lymphoma and leukaemia patients undergoing chimeric ant...

OBJECTIVE: Amyloidosis is a chronic disease associated with proteinuria and can progress to renal failure. The diagnosis and treatment of the underlying cause is therefore important. In this study at a university hospi...