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Abstract Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents and has been associated with poorer neurocognitive performance, but the biological mechanisms driving symptom variability an...

Abstract Half of all newborn neurons in the developing brain are removed via efferocytosis - the phagocytic clearance of apoptotic cells. Microglia are brain-resident professional phagocytes that play important roles in ...

ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contribut...

Marker selection precision in neuronal studies is critical for reliable neuron identification. However, it largely depends on the experimental context. Variations in neuronal marker specificity across experimental models...

Abstract Mutations in the CYFIP2 gene, particularly the R87C variant, are associated with severe epileptic encephalopathy, and present challenges for therapeutic development. This study utilized CRISPR/Cas9-edited human ...

In the central nervous system (CNS), programmed cell death (PCD) of neurons, is precisely regulated by various biomolecules to maintain neuronal development, establish neural structures, and maintain CNS homeostasis. Und...

The signaling pathways that control embryonic development and migration of gonadotropin-releasing hormone (GnRH) neurons, as well as the postnatal fate and function of differentiated cells, are the subject of ongoing res...

Short-chain perfluoroalkyl substances (PFAS), such as perfluorobutanoic acid (PFBA), are increasingly detected in agricultural soils, irrigation water, and crop tissues, yet their biological effects at low, environmental...

Organotypic slice culture is a sophisticated technique historically used in cellular and developmental neurobiology to investigate three-dimensional architecture and cellular interactions. Maintaining thin tissue slices ...

Abstract Background SPTBN1 encodes βII-spectrin, a cytoskeletal protein essential for neuronal structure and function. Pathogenic variants in this gene cause a neurodevelopmental disorder known as DDISBA (Developmental ...

Abstract Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure. We...

In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

Abstract Objective The study aimed to evaluate the hypoxia-induced brain injury and neuroprotective effects of pyrimidine and its derivative, arylvinylpyrimidine (AVP), in the freshwater catfish, Heteropneustes fossilis....

Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental drive...

Tesis de licenciatura El gen Gpm6a fue identificado como un gen de respuesta al estrés en animales sometidos a diferentes modelos de estrés crónico. En humanos, diferentes patologías neuropsiquiátricas se han asocia...