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This article examines everyday life at the edge of systemic collapse, focusing on how the disintegration of the Soviet Union and the emergence of independent Uzbekistan were experienced and interpreted by members of the ...

The empirical ordering of the upper castes through scriptural doctrines delegitimized the subaltern epistemology and impeded the possibility of any form of resistance. The article finds relevance in delving deep into the...

This article presents a transnational oral history of Maadhuri Hireker (b. 1940), a first-generation educated Ambedkarite woman whose life traverses rural Maharashtra, the historic moment of Buddhist conversion in 1956, ...

Serum sickness is an immune complex-mediated hypersensitivity reaction, classically manifested by the triad of fever, rash, and arthralgias. It results from the formation and deposition of antigen–antibody complexes, l...

The nuclear factor kappa light-chain enhancer of activated B cells (NFKB1) pathway is a central regulator of inflammatory gene expression. NFKB1 haploinsufficiency can present with common variable immunodeficiency (CVID)...

IntroductionBone-seeking radiopharmaceuticals are the treatment of choice with clinical benefits for patients with extensive skeletal metastases, but they can also cause serious radiation-related adverse events (rrAEs). ...

BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...

Congenital adrenal hyperplasia (CAH) due to 11β-hydroxylase deficiency is an uncommon disorder characterized by impaired cortisol synthesis, hyperandrogenism, and mineralocorticoid excess. The coexistence of Leydig cell...

IntroductionVaginal seeding has been proposed to restore the microbiome of babies born via caesarean section, but the associated risk of infection is unknown. We present the first case of disseminated candidiasis after v...

IntroductionSporotrichosis is an uncommon but emerging opportunistic infection in immunocompromised patients. Primary pulmonary sporotrichosis can disseminate and result in significant morbidity and mortality, despite tr...

Abstract Objectives To investigate risk factors for early childhood caries (ECC) among 1–2-year-old children in Beijing and to assess the effect modification of baseline caries experience on the associations between ot...

IntroductionAdenosine deaminase–deficient severe combined immunodeficiency (ADA-SCID) is an autosomal recessive disorder comprising ∼15% of SCID cases. Newborn screening (NBS) relies on T cell receptor excision circl...

Abstract Background Pancreatic portal hypertension (PPH) is a distinct form of sinistral (left-sided) portal hypertension, primarily resulting from pancreatic diseases such as acute or chronic pancreatitis and pancreatic...

This study examines how digital archives and smart city technologies can preserve collective memory during Zaporizhzhia’s post-war rebuilding. Using digital archival research, it explores how digital archives can safeg...

We report a previously healthy 4-year-old female presenting with a diffuse, recurrent, pruritic, erythematous rash involving the entire body with eight episodes over 2 years, each lasting 7–10 days. The rash reliably a...

Abstract Background Scurvy has re-emerged in association with neurodevelopmental and eating disorders, particularly selective eating. This study aimed to investigate the clinical characteristics of pediatric scurvy cases...

Abstract Background Preterm low birth weight (PLBW) is a major global contributor to neonatal morbidity and mortality. This study aims to develop and evaluate a novel artificial neural network (ANN) based predictive mode...

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED/APS-1) is a monogenic disorder of failed central tolerance caused by deleterious variants in the autoimmune regulator (AIRE) gene. Interferon-γ-driv...

BackgroundBehçet’s disease is a multisystem inflammatory disorder whose diagnosis can be challenging due to overlapping features with other inflammatory conditions and primary immunodeficiencies (1). In patients with ...

Abstract Background A frequent electrolyte imbalance, hypocalcaemia can cause anything from asymptomatic symptoms to potentially fatal neuromuscular and cardiac symptoms. Tetany, carpopedal spasm, and ECG abnormalities s...

BackgroundComplex inflammatory phenotypes in children can pose significant diagnostic challenges, particularly when clinical, histopathologic, and immunologic findings do not conform to established diagnoses. We present ...

Patients with STAT1 gain-of-function (GOF) variants may present not only with chronic mucocutaneous candidiasis and other forms of immunodeficiency but also with a broad-spectrum of autoimmune manifestations, for which J...

IntroductionRelA deficiency is a recently recognized inborn error of immunity (IEI) caused by mutations in the RELA gene. RelA is a transcriptional factor in the NF-kB pathway. Deficiency of RelA leads to impaired downre...

Abstract Background Although associations between periodontitis and metabolic diseases are established, published data about the correlation of advanced glycation end products (AGEs) and periodontal inflammation are scar...