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Background This study evaluated the effectiveness and safety of grapiprant for treatment of pain in dogs with osteoarthritis (OA). Hypothesis/Objectives Grapiprant will relieve pain as measured by the owner's and veterin...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

Abstract Background Knee osteoarthritis (OA) is a leading global cause of disability, yet conventional tools lack sensitivity for early detection and precise prognostication. Artificial intelligence (AI) and machine lear...

Abstract Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms. While i...

Benzo[a]pyrene (BaP), a widespread environmental pollutant, has been increasingly implicated in the pathogenesis of chronic degenerative diseases. Environmental pollutants have recently been recognized as emerging risk f...

Abstract Background Leg length discrepancy (LLD) has been implicated as a biomechanical factor contributing to hip osteoarthritis (OA), yet the extent of its influence remains unclear. This study examines the correlation...

Abstract Knee osteoarthritis (KOA) is a degenerative joint condition characterized by progressive cartilage deterioration and chronic pain, leading to functional impairment. Bone marrow-derived orthobiologics, such as bo...

Subchondral bone H-type angiogenesis and increased permeability are critical in osteoarthritis (OA) progression, yet the underlying regulatory mechanisms remain unclear. This study utilized proteomic analysis to identify...

ObjectiveTo track recent progress in the evaluation of orally administered glucosamine and/or chondroitin sulfate for osteoarthritis-related outcomes， and reanalyze the evaluation results.MethodsDatabase （CNKI， PUB...

Abstract Background Knee osteoarthritis (KOA) is a prevalent degenerative joint condition marked by progressive loss of articular cartilage and chronic inflammation. Recent studies have recognized Cellular Communication ...

Abstract Background Ankle arthrodesis is an established procedure for end-stage ankle osteoarthritis. Besides the known limited functionality, gait and foot arch changes are accompanying pathologies, which are little inv...

Introduction Osteoarthritis is a frequent degenerative joint disease, affecting older individuals in particular. When non-surgical treatment options are no longer effective or warranted, surgical options include single c...

Abstract Background Frunevetmab, a felinized antinerve growth factor monoclonal antibody, effectively decreases osteoarthritis (OA) pain in cats. Objective To evaluate the efficacy of frunevetmab given at monthly interva...

Background: Glenohumeral osteoarthritis (GHOA) is a common cause of impaired lifestyle, quality of life, and emotional well-being. Despite its frequency, there is insufficient evidence to recommend specific management st...

Background: Traumatic anterior shoulder instability (ASI) is common among young, active patients, with a progression to glenohumeral osteoarthritis (OA) in up to 55% of patients. Surgical stabilization procedures are rou...

Background: The effect of hip arthroscopy on the natural progression of osteoarthritis is still unclear. Purpose: To clarify the relationship between unilateral hip arthroscopy, the size of the cam lesion, and its excisi...

Background: The growth in popularity of unicompartmental knee arthroplasty (UKA) has far outpaced that of total knee arthroplasty (TKA). A major challenge with UKA is symptomatic progression of osteoarthritis (OA), which...

Abstract Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organs/tissues in metabolism and inflammation, yet little is known about the contribution of liver and marrow adipose tissu...

# Background Hip Osteoarthritis (OA) is a degenerative joint disease associated with pain, reduced physical function, and impaired quality of life (QoL). Identifying patient characteristics associated with these outcomes...

Un león de montaña (Felis concolor), macho de 23 años de edad Montaña desarrollo una claudicación crónica en el parque zoológico “El Pinar”, Caracas-Venezuela. Se le practico eutanasia. Macroscópicamente, la ...

IntroductionOsteoarthritis (OA) is a common joint disease characterized by progressive biomechanical deterioration of cartilage tissue. This study aims to develop an explainable ensemble machine learning model capable of...

Abstract Objective To examine whether long-term opioid use after total knee arthroplasty (TKA) is associated with subsequent risks of major adverse cardiovascular events (MACE) and all-cause mortality in patients with kn...

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

Aims: Cementless femoral fixation is widely used in total hip arthroplasty (THA), with increasing interest in shorter femoral component designs. These femoral components aim to preserve proximal bone, promote physiologic...