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Airborne particulate matter 10 (PM10) induces lung inflammation. However, interventions remain limited. We evaluated the protective effects of Chrysanthemum zawadskii var. latilobum (CZL) against PM10-induced lung injury...

Breast cancer is a major public health problem worldwide, leading to an urgent need for the development of new strategies to improve treatment efficacy and manage drug resistance. Doxorubicin is among the most commonly u...

BackgroundMyocarditis is an inflammatory cardiomyopathy characterized by high level of inflammatory cell infiltration and progressive cardiac dysfunction. The underlying pathogenesis involves direct pathogen damage and i...

Abstract Objective This study aimed to elucidate the molecular mechanisms by which Apigenin (APG) reverses MET-TKI resistance in non-small cell lung cancer (NSCLC). Methods Network pharmacology and molecular docking were...

Yuan Cui,1,2 Jingyi Hu,1 Yanan Li,1 Yiheng Tong,1 Hong Shen1 1Department of Gastroenterology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001,...

Abstract Eleusine coracana (L.) Gaertn., commonly known as Ragi or finger millet, is a nutrient-rich cereal traditionally valued for its health-promoting properties. However, its precise molecular mechanisms and therapeu...

Ulcerative colitis (UC), an inflammatory bowel disease, is characterized by inflammation and oxidative stress. Oyster, a high-nutrition mariculture shellfish, is a vital source of bioactive peptides. This study aimed to ...

Phα1β, a peptide toxin purified from Phoneutria nigriventer spider venom, has a dual antinociceptive effect, inhibiting high-voltage-activated calcium channels and antagonising the TRPA1 receptor that differentiates it...

B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmu...

Tianhang Peng,1,* Wanyuan Liang,1,* Ju Wei,2 Ni Ding,3 Xiuqi Tang,3 Zike Zhang3 1School of Sports Science, Beijing Sport University, Beijing, 100084, People’s Republic of China; 2School of English Studi...

Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ex...

IntroductionAvian pathogenic Escherichia coli (APEC) infection poses a serious threat to the poultry industry and is increasingly difficult to control because of antimicrobial resistance.MethodsThis study combined microb...

IntroductionAnti-amyloid antibodies have the potential to become the standard of care in Alzheimer’s Disease (AD) and large datasets from clinical trials allow the testing of predictive models on fluid biomarkers and f...

Regulatory science governing monoclonal antibody development has undergone a profound transformation over the past decade, shifting from empiricism-driven paradigms toward evidence-efficient, mechanism-based frameworks g...

Medicarpin (MED) is an isoflavonoid compound derived from traditional Chinese medicine (TCM). Numerous preliminary experimental studies have shown that MED has significant pharmacological effects in the treatment of canc...

Fuzi, the processed lateral root of Aconitum carmichaelii Debeaux (Ranunculaceae), is a vital yet highly toxic botanical drug in traditional Chinese medicine. However, its narrow therapeutic window, driven by highly toxi...

IntroductionThe use of medical cannabis products is expanding, yet real-world data on associated adverse events (AEs) remain limited. Controlled trials often exclude diverse patient populations and product types, making ...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Depression during pregnancy is common worldwide, with higher prevalences in low-income countries compared to high-income countries. Yet, current antidepressant dosing strategies in pregnant patients rarely account for th...

Abstract In this paper we present an analysis of the role of randomized controlled trials (RCTs) in the regulation of health claims (claims about additional health benefits provided by foods). Currently there is a line o...

IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...

Preeclampsia represents an unmasking of underlying vascular and metabolic vulnerability during the physiologic stress of pregnancy. Current first-trimester screening relies heavily on body mass index which incompletely c...

Sujong Lee,1,2 Heejae Won,1,2 Kyung-Sang Yu,1,2 Dae Young Lee,3 SeungHwan Lee1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; ...