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The synthetic polymers and their combinations were employed to retard the release of nimesulide from microcapsules. Microcapsules were prepared in different ratios of Eudragit RL 100 and hydroxy propyl methyl cellulose (...

Papain has been known by many decades for wounded tissues repair. However, papain stability is not high enough to be commercialized in a stable pharmaceutical form; therefore its use is limited. The strategy to entrap pa...

In the present investigation, extended release tablets of metoprolol succinate were developed using cellulose derivatives and natural gums as matrix formers and were evaluated for its extended release characteristics. Th...

The main objective of this work was to obtain biodegradable nancomposites from polycaprolactone and bentonite with optimized mechanical properties by the chemical modification of the clay (cation exchange reactions). Fir...

The project was aimed to develop floating microcapsules (FMs) using combination of a hydrophobic (ethyl cellulose, EC) and hydrophilic polymer (hydroxy propyl methyl cellulose, HPMC), and to evaluate them. An easy and no...

Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and charact...

The objective of the present research was to develop acyclovir ophthalmic emulgels using different polymers such as Pluronic F 127 (PF 127), Gelrite, Carbopol 934P, hydroxypropylmethylcellulose (HPMC K100M) and sodium ca...

The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated u...

The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although th...

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide ...

Spherical crystallization (SC) is a promising alternative for improiving micromeritic properties and dissolution rate of active pharmaceutical ingredients. In the present work spherical agglomerates of carvedilol (CAR) w...

To select the suitable concentration level of controlled release polymer for the formulation of predefined extended release formulation based on the solubility behaviour of active substance, we have formulated and evalua...

The purpose of the present research work was to produce a biphasic delivery system for Diclofenac sodium. A dual component tablet made up of a sustained release beads and immediate release tablet coat was prepared by dir...

Oral route of drug administration is the most preferred route of drug administration but this route has its own limitations like pH of gastric media and controlling release rate of water soluble drug. To overcome these l...

The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit...

The aim of the study was to formulate and evaluate controlled release microspheres. Ciprofloxacin HCl, belonging to the class of fluroquinolones, was chosen as the model drug. The drugloaded microspheres were prepared wi...

The deposition of chlorhexidine base on thermosensitive N-isopropylacrylamide polymeric microparticles was assessed in this study using energy dispersive X-ray spectrometry (EDXS) in scanning electron microscopy (SEM) se...