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With the rapid growth of electronic health records, medical imaging, and high-throughput omics data, precision oncology faces increasing demands for cross-modal information integration and complex clinical decision suppo...

Abstract BackgroundPrecision oncology (PO) improves and extends the lives of patients living with cancer, but multiple studies have documented its underuse in practice. Specifically, studies note a significan...

This report describes a rare case of a vascular-origin malignant tumor (intimal sarcoma or carcinosarcoma) extending from the right pulmonary hilum along the pulmonary artery in a 44-year-old man. The patient underwent r...

Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...

The clinical management of refractory pituitary neuroendocrine tumors (PitNETs) remains a formidable challenge due to pervasive resistance to traditional therapies. Current therapeutic failures appear closely associated ...

Abstract Background Disruption of cellular proteostasis leads to the accumulation and persistence of pathogenic proteins that drive oncogenesis. Key oncogenic and tumor suppressor proteins are frequently dysregulated in ...

ObjectivesThis study aims to delineate the research landscape and evolutionary trajectory of the GLIM criteria in oncology. By mapping development from initial diagnosis to emerging frontiers, it identifies research hots...

Abstract Background The ageing and growing population, rising cancer rate, and increased healthcare demand drive higher medical costs. Integrating Artificial Intelligence (AI) into oncology revolutionizes cancer diagnosi...

Resumen: Las mutaciones germinales en genes de predisposición al cáncer han dejado de ser una información sólo asociada al riesgo de cáncer hereditario, en la actualidad se han convertido en un verdadero motor de ca...

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the head and neck region, where conventional therapies have limited efficacy and patients have poor prognosis. As newly identified metal i...

Abstract Prostate cancer continues to impose a significant health burden worldwide and in the United States, with rising incidence, persistent mortality rates, and disparities in both incidence and patient outcomes. Adva...

Background and purpose: The use of Magnetic Resonance imaging (MRI) for radiotherapy (RT) planning for locally advanced non-small cell lung cancer (LA NSCLC) could improve RT precision due to its superior soft tissue def...

The treatment paradigm for advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations is undergoing a significant transition. While third-generation tyrosine kinase inhibitors (TKIs) like osimertinib have long ...

Background: ERBB2 aberrations are established oncogenic drivers with validated therapeutic relevance in breast cancer and emerging indications across solid tumors. In gastrointestinal malignancies, the prevalence, molecu...

Chemotherapy-induced gastrointestinal dysfunction (CIGD) is a multifactorial clinical syndrome that substantially limits treatment tolerance, continuity, and quality of life in patients with cancer. Although targeted the...

PurposeGlobally, colorectal cancer (CRC) stands as the third most common type of cancer, a ranking that has remained consistent over recent years. However, the scenario diverges in Saudi Arabia, where CRC ascends to the ...

BackgroundYoung women with localized breast cancer represent a clinically distinct population with heterogeneous outcomes, yet age-specific prognostic models remain limited. Conventional risk stratification tools derived...

This commentary discusses the FDA’s drug approvals in 2025, with a particular focus on cancer therapies and the role of companion diagnostics (CDx). Cancer has emerged as the leading therapeutic area, accounting for 35...

Introduction: The American College of Radiology (ACR) Bone-Reporting and Data System (Bone-RADS) gave a structured framework for assessing and reporting bone tumours. Aim: To evaluate the diagnostic performance of the...

BackgroundDelivering accurate radiation doses in heterogeneous tissues is critical in radiotherapy, yet conventional algorithms often lose accuracy in complex scenarios. Monte Carlo (MC) simulation offers a high-fidelity...

Abstract Background Apoptosis is a fundamental biological process and a central determinant of therapeutic response in breast cancer (BC). Resistance to immunotherapy is increasingly recognized to be driven, in part, by ...

Abstract Advances in artificial intelligence (AI) and multi-omics integration are reshaping precision oncology by enabling deeper mechanistic understanding, improved characterization of tumor heterogeneity, and the accel...

Abstract Precision oncology relies on access to high-quality data for increasingly smaller patient subgroups. The international atomCAT consortium investigates the potential of federated learning to support this, using a...

ABSTRACT Pyroelectric catalysis has shown promising prospects for sustainable energy generation and medical treatments. However, its potential is limited by intrinsically low pyroelectric coefficients and insufficient in...