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Abstract Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of ...

Abstract Glaucoma trabecular meshwork (GTM) cells cultured in vitro retain many characteristics of their in situ phenotype. Here, we used isobaric tandem mass tags (TMTpro) to label peptides from glaucomatous and non-gla...

Abstract Black rhinoceros are critically endangered due to poaching in the wild (in situ). Globally, fewer than 200 animals are maintained as an ex situ insurance population. Unfortunately, the ex situ population faces m...

Abstract Background Proteins represent the dynamic downstream products of genes, and have the potential to substantially increase understanding of the complexities of cancer biology. Undifferentiated pleomorphic sarcoma ...

The present study presents the first characterization of a full cytohesin-2 knockout and establishes cytohesin-2 as a critical factor for perinatal development, identifying a previously unrecognized role of cytohesin-2 i...

Intrauterine growth restriction is described as a fetus not reaching its growth potential during pregnancy. Placental malperfusion is the main cause of Intrauterine growth restriction . Management of Intrauterine Gowth ...

Abstract Background Genetic aberrations are among the critical driving factors of lung cancer. Importantly, the impact of genetic variations on proteomic dysregulations with the goal of characterizing potential diagnosti...

Abstract Background Proteins and RNA circulate in plasma and can offer insights into human physiology. Yet, despite their clinical importance, direct comparisons between these analytes remain unexplored. Methods: Here, w...