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Materias / palabras clave: antiparasitic compounds; Chagas disease; drug repurposing; Leishmania; leishmaniasis; Toxoplasma gondii

Abstract Introduction Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis, a frequently diagnosed infection that accounts for more than half of non-viral sexually transmitted diseases. An increased i...

Abstract This study introduces two recently developed bio-inspired metaheuristic algorithms, Artificial Protozoa Optimizer (APO, 2024) and Dung Beetle Optimizer (DBO, 2023), into long short-term memory (LSTM) networks fo...

Abstract Toxoplasma gondii, Plasmodium spp., and Leishmania spp. collectively infect billions and cause millions of deaths worldwide. In French Guiana, the geographical coexistence of malaria, acute toxoplasmosis, and cu...

Abstract Background Identification of risk and protective factors for canine visceral leishmaniasis (CVL) is essential to understand the epidemiology of the disease and direct prevention and control strategies. Building ...

The diversity of Sarcocystis spp. infecting Alaskan marine mammals is largely unknown, which is relevant in a region of the world where hunting and consumption of marine mammals is essential to Alaskan native food securi...

Methane (CH4) generated during ruminal fermentation in ruminants is a major contributor to greenhouse gas emissions and represents a substantial loss of dietary energy. Therefore, mitigating enteric CH4 emissions through...

Abstract Trypanosoma evansi is an important protozoan pathogen affecting various animal species particularly camels and horses, leading to significant economic losses. The ineffective control of T. evansi is attributed t...

Background The field of extracellular vesicles (EVs) has advanced considerably in recent years with new findings stemming from technical improvements in their isolation and characterization, expanding their potential as ...

Abstract Background Leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoa. The disease manifests in several clinical presentations including cutaneous, mucocutaneous, and visceral leishmaniasis....

Abstract Background Cryptosporidium spp. is an important intestinal protozoan parasite causing morbidity and mortality in immunocompromised patients, particularly those with HIV+/AIDS. A cross-sectional study was conduct...

Abstract Background Leishmaniasis is a vector-borne disease caused by a protozoan parasite of the genus Leishmania. The infection is transmitted by the bite of infected female sandflies of the genus Phlebotomus in the Ol...

Abstract Background Leishmaniasis is a vector-borne protozoan disease with cutaneous, mucocutaneous, and visceral forms. In Europe, most cases involve Old World species, while imported New World infections are rare. We r...

Cryptosporidiosis is a zoonotic protozoan disease that affects humans and animals. This disease, which causes diarrhea, dehydration, weight loss, stunted growth, and death, especially in newborn calves, leads to economic...

Abstract Infections with the protozoan parasite Trypanosoma cruzi are widespread in the Americas and can lead to severe cardiac and/or gastrointestinal pathology. Current treatments are limited to monotherapies character...

Circular Rep-encoding single-stranded DNA (CRESS-DNA) virus Rep proteins are multidomain enzymes that mediate viral DNA rolling-circle replication. Reps nick viral DNA to expose a 3' end for polymerase extension, provide...