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Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience

Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience

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Federica Agosta et al · BMC · 2026 · ISSN 1758-9193

Abstract Background Anti-amyloid monoclonal antibodies are entering clinical practice for early symptomatic Alzheimer’s disease (AD), but European real-world data on feasibility, safety, and biomarker monitoring remain...

LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng

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Real-world effectiveness of total neoadjuvant therapy in locally advanced rectal cancer: a multicenter retrospective study

Real-world effectiveness of total neoadjuvant therapy in locally advanced rectal cancer: a multicenter retrospective study

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Osman Sütcüoğlu et al · Springer · 2026 · ISSN 2730-6011

Abstract Background This study aims to evaluate the effectiveness and real-world applicability of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer (LARC), focusing on pathological complete ...

LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng

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The OPERA project: a harmonized multinational real-world ART database across Italy and Germany (2016–2020) and a descriptive snapshot of contemporary clinical practice

The OPERA project: a harmonized multinational real-world ART database across Italy and Germany (2016–2020) and a descriptive snapshot of contemporary clinical practice

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Andrea Francavilla et al · Frontiers Media S.A · 2026 · ISSN 2673-3153

IntroductionAssisted reproductive technology (ART) practice varies widely across centers and evolves rapidly, often outpacing the generation of randomized evidence. OPERA (Observational ProjEct for a Research database fo...

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Isavuconazole therapeutic drug monitoring in real-world clinical practice: an age-stratified analysis of determinants

Isavuconazole therapeutic drug monitoring in real-world clinical practice: an age-stratified analysis of determinants

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Zhaoyi Tan et al · Frontiers Media S.A · 2026 · ISSN 1663-9812

ObjectivesAlthough therapeutic drug monitoring (TDM) for isavuconazole (ISA) is not routinely recommended, its utility in specific populations remains debated. This study aimed to elucidate the need for ISA TDM and to id...

LCC LCC:Therapeutics. PharmacologyIdioma eng

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Impact of a structured nurse-delivered multi component SGLT2 inhibitor initiation and optimization pathway on kidney function and clinical outcomes in type 2 diabetes and chronic kidney disease: a real-world retrospective study

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Liang Huang et al · BMC · 2026 · ISSN 1471-2369

Abstract Background The implementation gap between evidence-based SGLT2 inhibitor therapy and real-world practice remains substantial in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Pro...

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Who Is Really Deciding? AI and Clinical Judgement in Dentistry

Who Is Really Deciding? AI and Clinical Judgement in Dentistry

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Owais A. Farooqi · Elsevier · 2026 · ISSN 0020-6539

ABSTRACT: The integration of AI in dental practice, primarily through AI-enabled software, influences clinical workflows by promoting rapid decision-making and potentially increasing bias stemming from its automation bia...

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Immersive virtual reality for reducing public speaking anxiety in students accessing a university psychological counseling service: protocol for a randomized controlled trial

Immersive virtual reality for reducing public speaking anxiety in students accessing a university psychological counseling service: protocol for a randomized controlled trial

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Gianluca Mariano Colella et al · BMC · 2026 · ISSN 2050-7283

Abstract Background Public Speaking Anxiety (PSA) is a form of social anxiety spread among university students, negatively affecting both academic performance and overall psychological well-being. Virtual Reality (VR)–...

LCC TENDOlBzeWNob2xvZ3k~Idioma eng

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Evaluation of large language models in a pulmonology outpatient clinic using structured clinical data and chest radiographs: a single-center prospective observational study

Evaluation of large language models in a pulmonology outpatient clinic using structured clinical data and chest radiographs: a single-center prospective observational study

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Hayriye Bektaş Aksoy et al · Frontiers Media S.A · 2026 · ISSN 2296-858X

IntroductionLarge language models (LLMs) may support clinical reasoning, yet real-world outpatient studies integrating structured clinical data with chest radiographs (CXRs) remain limited. We compared three LLMs for pul...

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Evaluation of the implementation of clinical simulation as a learning tool: an 18-month experience at a university hospital

Evaluation of the implementation of clinical simulation as a learning tool: an 18-month experience at a university hospital

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Munir Mohamed Mimun et al · Frontiers Media S.A · 2026 · ISSN 2296-858X

IntroductionClinical simulation has become established as a key tool in healthcare education; however, evidence regarding its multidisciplinary implementation in university hospitals, integrating distinct professional pr...

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External ventricular drainage in modern neurosurgical practice: optimization, standardization, and emerging guidance technologies

External ventricular drainage in modern neurosurgical practice: optimization, standardization, and emerging guidance technologies

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Jack Hennen et al · Frontiers Media S.A · 2026 · ISSN 1664-2295

External ventricular drain (EVD) placement is a standard neurosurgical procedure for cerebrospinal fluid diversion and intracranial pressure monitoring, yet conventional freehand techniques are associated with substantia...

LCC LCC:Neurology. Diseases of the nervous systemIdioma eng

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From Stakeholder Expectations to Curriculum Gaps in EMS Education: Implications for Learning-to-Practice Alignment

From Stakeholder Expectations to Curriculum Gaps in EMS Education: Implications for Learning-to-Practice Alignment

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Tippayanate N et al · Dove Medical Press · 2026 · ISSN 1179-7258

Nantawan Tippayanate,1,2 Kiattisak Chaiprom,1 Waranya Chatuphonprasert,3 Ajchara Khamya,1 Jantana Sriprow,1 Chattarin Sripol,1,2 Maitree Thronsao1,2 1Field of Study in Paramedicine, Faculty of Medicine, Mahasarakham Univ...

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Artificial intelligence-based analysis of visual electrophysiological signals for clinical interpretation support

Artificial intelligence-based analysis of visual electrophysiological signals for clinical interpretation support

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Mathieu Seraphim et al · Frontiers Media S.A · 2026 · ISSN 1662-453X

IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imagi...

LCC LCC:Neurosciences. Biological psychiatry. NeuropsychiatryIdioma eng

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Designing a stakeholder-informed digital learning model integrating virtual reality and e-learning for complementary therapy-based postpartum preeclampsia education

Designing a stakeholder-informed digital learning model integrating virtual reality and e-learning for complementary therapy-based postpartum preeclampsia education

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Susilo Rini et al · Universitas Muhammadiyah Purwokerto · 2026 · ISSN 1693-7309

Background: Postpartum preeclampsia remains a significant contributor to maternal morbidity and mortality in Indonesia. Midwives, as frontline maternal health providers, are expected to deliver holistic care; however, st...

LCC LCC:MedicineIdioma eng

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Final data from the German AHEAD study: effectiveness and safety of octocog alfa and rurioctocog alfa pegol for hemophilia A in a real-world setting

Final data from the German AHEAD study: effectiveness and safety of octocog alfa and rurioctocog alfa pegol for hemophilia A in a real-world setting

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Robert Klamroth et al · SAGE Publishing · 2026 · ISSN 2040-6215

Background: Octocog alfa and rurioctocog alfa pegol have demonstrated efficacy in the prevention and management of bleeding associated with hemophilia A (HA) in clinical trials. The German AHEAD study (DRKS00000556) was ...

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Frequência de leveduras em fluido vaginal de mulheres com e sem suspeita clínica de candidíase vulvovaginal Frequency of yeasts in vaginal fluid of women with and without clinical suspicion of vulvovaginal candidiasis

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João Luciano Andrioli et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2009 · ISSN 0100-7203

OBJETIVO: estudar a candidíase vulvovaginal em mulheres com e sem suspeita clínica a partir de fluido vaginal, identificando frequência de Candida spp. e associando a fatores de risco intrínsecos e extrínsecos. MÉT...

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Optimal auxiliary-covariate-based two-phase sampling design for semiparametric efficient estimation of a mean or mean difference, with application to clinical trials

Optimal auxiliary-covariate-based two-phase sampling design for semiparametric efficient estimation of a mean or mean difference, with application to clinical trials

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Gilbert, Peter B. et al · John Wiley & Sons Ltd · 2014 · ISSN 0277-6715

To address the objective in a clinical trial to estimate the mean or mean difference of an expensive endpoint Y, one approach employs a two-phase sampling design, wherein inexpensive auxiliary variables W predictive of Y...

Idioma eng

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Self-Perceived Confidence and Clinical Preparedness in Restorative Dentistry Among Undergraduate Dental Students

Self-Perceived Confidence and Clinical Preparedness in Restorative Dentistry Among Undergraduate Dental Students

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Hazza A. Alhobeira et al · SAGE Publishing · 2026 · ISSN 2382-1205

Background Key goals of undergraduate dental education include developing clinical confidence and preparing students for practice. This is particularly important in restorative dentistry when students transition from pre...

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Study protocol for a randomised evaluation of a brief psychological intervention for clinically stressed parents of adolescents: Approach for Parenting Teenagers (APT)

Study protocol for a randomised evaluation of a brief psychological intervention for clinically stressed parents of adolescents: Approach for Parenting Teenagers (APT)

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Alex Desatnik et al · BMC · 2026 · ISSN 2050-7283

Abstract Background Adolescence can be a stressful and difficult period for young people and parents, with many changes occurring during this time, and a heightened risk of mental health problems for adolescents. The qua...

LCC TENDOlBzeWNob2xvZ3k~Idioma eng

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Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps

Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps

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Katie H. Thomson et al · BMC · 2026 · ISSN 1745-6215

Abstract Background Adaptive designs (ADs) are increasingly used, whereby outcome data accumulated during the trial may inform a trial’s course in accordance with pre-specified rules at interim analyses. The benefits h...

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Treatment trajectories of patients with borderline personality disorder prescribed pharmacotherapy: real-world insights from a retrospective observational study

Treatment trajectories of patients with borderline personality disorder prescribed pharmacotherapy: real-world insights from a retrospective observational study

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Carissa White et al · BMC · 2026 · ISSN 1471-244X

Abstract Background Borderline personality disorder (BPD) is a significant cause of morbidity with no approved pharmacological treatment. We assessed treatment trajectories of patients with BPD in real-world clinical pra...

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Drug Patterns and Economic Costs Among Patients with Hereditary Angioedema

Drug Patterns and Economic Costs Among Patients with Hereditary Angioedema

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Kutrieb E et al · Dove Medical Press · 2026 · ISSN 1178-6965

Emily Kutrieb,1 Derek Weycker,1 Montserrat Vera-Llonch,2 Arthur Zbrozek,3 Kevin Ottino,1 William R Lumry4 1Avalere Health, Washington, DC, USA; 2Ionis Pharmaceuticals, Boston, MA, USA; 3Ionis Pharmaceuticals, Carlsbad, C...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Fostering continuous quality improvement in a European rare disease network: Where are we now?

Fostering continuous quality improvement in a European rare disease network: Where are we now?

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Linde Margriet van der Kamp et al · BMC · 2026 · ISSN 1750-1172

Abstract Background The European Reference Network for rare Inherited and Congenital Anomalies (ERNICA) aims to improve care for patients with rare and complex digestive and gastrointestinal diseases across Europe throug...

LCC LCC:MedicineIdioma eng

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BrCaM an artificial intelligence model for surgical decision making in breast cancer

BrCaM an artificial intelligence model for surgical decision making in breast cancer

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Daniela Evangelista et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Optimizing surgical decisions in breast cancer is critical. Choosing between mastectomy and breast-conserving surgery (BCS) is complex due to heterogeneous pre-operative clinical factors. We developed BrCaM (Bre...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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