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Biofabricated scaffolds facilitate bona fide cellular interactions, cell type specification, and the formation of three-dimensional tissue architecture from human pluripotent stem cells (hPSCs). However, xenogenic biomat...

Regenerative bicycle trainers support more sustainable indoor cycling by converting a rider’s kinetic energy into electrical energy while producing a controllable resistive load. For a realistic riding feel, the relati...

The convergence of geopolitical instability and climate-related shocks has intensified the need for resilient food systems grounded in the regenerative principles of the Circular Economy (CE) while advancing the United N...

Abstract Background To compare the antibacterial activity of conventional intracanal medicaments used in regenerative endodontic treatment (TAP, DAP, Ca(OH)₂, CHX gel) with novel hydrogel-based formulations (chitosan, ...

This article examines the startup period of a natural gas pipeline cryogenic reduction unit (CRU) within a gas distribution station (GDS). The objective of the study is to determine the temperature distribution within a ...

Materias / palabras clave: biomarkers; molecular regulation; neural stem cells; neuroplasticity; neurorehabilitation; regenerative medicine

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Background: Erectile dysfunction (ED) is a common condition among aging men, with limited response to first-line therapies in certain populations. This study aimed to systematically review and compare the efficacy of reg...

Abstract Collagen-based artificial corneas are a promising regenerative alternative to scarce donor tissue. However, their clinical success is limited by mechanical weakness, enzymatic degradation, and poor bio-integrati...

IntroductionThe secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This “cell-free” strategy offers a promising alternative to stem ...

Abstract Background Demineralized dentin matrix (DDM) can serve as a novel scaffold for dental tissue regeneration. This study aimed to assess the impact of two distinct sterilizing methods on morphology of Allo-DDM as w...

ntroducción: Últimas investigaciones en la biología celular y molecular del oído interno han aportado evidencias que apoyan nuevas modalidades terapéuticas en medicina regenerativa para restablecer la audición. Rec...

Abstract Background Metformin has emerged as a potential bioactive agent in regenerative medicine; however, its optimal concentration for enhancing dental pulp stem cell (DPSC) function remains unclear. This study evalua...

Abstract Knee osteoarthritis (KOA) is a degenerative joint condition characterized by progressive cartilage deterioration and chronic pain, leading to functional impairment. Bone marrow-derived orthobiologics, such as bo...

Abstract Background Mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but their clinical utility is limited by replicative senescence. Strategies that reverse aging while maintaining MSC identity...

Aging is characterized by measurable reductions in tissue repair, immune balance, and metabolic regulation. Increasing evidence suggests that these changes may arise, in part, from an insufficiency or altered quality of ...

Background: BPC-157 and GHK-Cu are synthetic peptides with potential in tissue repair, influencing molecular mechanisms in healing, angiogenesis and inflammation. Objective: This review synthesizes preclinical and cli...

Diaphragmatic myoblasts (DM) are stem cells of the diaphragm, a muscle displaying high resistance to stress and exhaustion. We hypothesized that DM modified to overexpress connexin-43 (cx43), seeded on aligned poly (l-la...

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...

CD40L-deficient X-linked hyper IgM (XHIGM) syndrome is characterized by defective B cell class switching, deficiency of immunoglobulins G, A, and E, plus other immune abnormalities due to disrupted CD40L–CD40 interacti...

Li Tao,1,2,* Meiling Tai,3,* Zhuang Zhou,3 Zhenwen Chen,1 Rongjinlei Zhang,1 Yuanlong Ge,1 Zhenyu Ju1 1Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative...

Abstract The field of regenerative medicine for Parkinson’s disease (PD) has reached a pivotal moment. After decades of preclinical research, recent first-in-human clinical trials demonstrated that cell replacement the...

Midlife represents a biological “phenotype transition” for women, during which sarcopenic obesity risk can rise despite stable BMI. Evidence anchored to the STRAW + 10 framework suggests that the interval surroundi...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...