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IntroductionAccurate segmentation of retinal blood vessels is essential for the early diagnosis of ophthalmic and systemic diseases such as diabetes, hypertension, and cardiovascular disorders. However, challenges such a...

ABSTRACT Retinal ganglion cell (RGC) degeneration represents a cardinal etiology of irreversible vision loss in glaucoma, where efficacious regenerative therapies remain scarce. RGC replacement therapy holds promise for ...

Abstract Objective Retinal neovascularization is a leading cause of irreversible blindness worldwide. Chinese herbal medicines have unique therapeutic properties, such as antioxidant, anti-inflammatory, and neuroprotecti...

Abstract Background Progressive retinal atrophy (PRA) was diagnosed in four related male English Cocker Spaniels (ECS) between the ages of 3 and 4 years. All affected dogs were born to clinically unaffected parents that ...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

BackgroundLycium barbarum glycopeptide (LbGp) has been reported to exert neuroprotective effects, yet its role in chronic ocular hypertension (COH) and the underlying mechanisms remain unclear. This study investigated wh...

Background: A full-thickness macular hole (FTMH) causes central vision loss. Although modern vitrectomy techniques achieve high closure rates, functional recovery remained variable. Aim: This study aimed to describe th...

BackgroundRetinal hemangioblastoma (RH) is a benign, highly vascularized tumor arising from the neurosensory retina. It may occur sporadically or as a manifestation of Von Hippel–Lindau (VHL) disease. Here, we describe...

Abstract Background To evaluate the risk of Retinal Artery Occlusion (RAO) in individuals with Primary-Open Angle Glaucoma (POAG) using a large-scale real-world database. Methods This retrospective cohort study used the ...

Despite achieving high volumetric overlap, pixel-based deep learning segmentation approaches do not ensure true vascular connectivity, leading to fragmentations structurally analogous to Branch Retinal Artery Occlusions....

Abstract Stem cell-derived RPE replacement is a potential therapeutic for advanced AMD that is characterized by macular scarring and geographic atrophy leading to severe vision loss. Although the field of stem cell-diffe...

Carotid-Cavernous Fistulas (CCFs) are aberrant arteriovenous connections between the carotid arteries and the cavernous sinus. Although uncommon, they might manifest with subtle or deceptive symptoms, especially in young...

Abstract Lupus retinopathy (LR) is one of the most frequent and serious ocular complications of systemic lupus erythematosus (SLE), because it may cause irreversible visual impairment. The aim of this study was to evalua...

The route of administration is a crucial determinant of the success of stem cell-based therapies, especially in intraocular applications. It significantly influences therapeutic outcomes and the risk of adverse events. W...

Isac Wickman,1 Ivana Huzevkova,1 Marion Schroeder,1 Elisabet Granstam,2 Ulrika Kjellström,1 Monica Lövestam-Adrian1 1Department of Clinical Sciences Lund, Ophthalmology, Lund University, Lund, Sweden; 2Department of Su...

Objective. To evaluate the relationship between ophthalmic hemodynamic parameters, particularly the rheographic coefficient (RQ), and the activity of iris neovascularization in neovascular glaucoma (NVG) of different eti...

Objective: To compare clinical and structural outcomes of combination therapy (anti-VEGF + PDT) versus anti-VEGF monotherapy in patients with pachychoroid neovasculopathy (PNV) during 12-month follow-up. Materials and Me...

Abstract Cisplatin (CISP) is a platinum-based chemotherapeutic drugs that are commonly used to treat several types of cancers. However, its clinical application faces several hurdles that could limit its clinical efficie...

Abstract Background Duchenne muscular dystrophy (DMD) results from mutations in the DMD gene, which differentially affect dystrophin isoforms (Dp427, Dp260, Dp140, Dp71) expressed in distinct brain and retinal cell types...

ObjectiveIn the present study, we established a rat model of optic nerve injury to evaluate whether direct local delivery of neurotrophic agents following traumatic optic neuropathy (TON) enhances retinal ganglion cells ...

A new fluorescent sensor makes it possible to track the neurotransmitter GABA in freely moving animals.

ABSTRACT Background and Aim Non‐adherence to diabetes medication treatment is a recognized public health problem that can lead to unfavorable clinical, humanistic, and economic outcomes. This study aimed to analyze adh...

BackgroundPhakic intraocular lenses (pIOLs), used to correct high refractive errors, have since been associated with long-term complications including glaucoma and cataract formation. Elevated intraocular pressure (IOP) ...

Diabetic retinopathy (DR) is one of the leading causes of preventable blindness worldwide, making timely and accurate detection crucial for effective management. This study introduces DR-NetFusion, a novel hybrid deep le...