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Natural antisense transcripts (NATs) from eukaryotic genes, known as long non-coding RNAs (lncRNAs), are long transcripts that do not encode proteins. NATs play diverse functional roles in regulating the transcription, s...

Autoimmune rheumatic diseases (ARDs), often characterized by pain, constitute a diverse group of autoimmune conditions involving inflammation-mediated injuries to bones, joints, surrounding connective tissues, and occasi...

BackgroundSmall Nuclear Ribonucleoprotein Polypeptide A (SNRPA), an RNA-binding protein associated with HCC survival, emerges as a key regulator requiring mechanistic study.MethodsTo delineate SNRPA’s functions, we gen...

Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

Abstract Background Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains poorly characterized at the post-transcriptional regulation level. While alternative splicing (AS) perturbations drive...

Abstract Bovine respiratory disease (BRD) remains the leading cause of morbidity and economic loss in North American cattle production. Cattle at high risk of BRD are often managed through antimicrobial metaphylaxis, alt...

Abstract Long-read transcriptome sequencing (long-RNA-seq) revolutionizes transcriptome research by enabling full-length transcript analysis for comprehensive exploration of isoform diversity. We developed IFDlong, a pro...

In the context of climate change and the need to reduce pesticide and agrochemical use, the development of sustainable crops is becoming increasingly important. Epigenetic mechanisms, such as histone modifications, allow...

BackgroundThe integrated stress response (ISR) can cause high-grade serous ovarian cancer (HGSOC) cells to arrest in G1 phase, significantly suppressing their hyperproliferation. Nevertheless, the specific molecular mech...

Abstract Lung cancer remains the leading cause of cancer incidence and mortality globally, yet its molecular mechanisms remain poorly understood. Recent studies highlight the role of protein lactylation in regulating tum...

Abstract Background The dysfunction of osteoblasts has been identified as a pivotal contributor to bone erosion in rheumatoid arthritis (RA). Emerging evidence shows long non-coding RNAs (lncRNAs) as important regulators...

Abstract Regulatory T cells (Tregs) are key contributors to maintaining immune system stability, and their impairment has been linked to the pathogenesis of Graves’ disease (GD). However, the precise molecular mechanis...

Abstract Dysregulated expression of tumor suppressor genes can impair their functions, even promoting oncogenesis. Expression of p53β mRNA can be regulated by alternative splicing and RNA surveillance, otherwise transla...

Abstract Background In photosynthetic eukaryotes of the green lineage, the expression of the chloroplast genome is mainly regulated post-transcriptionally, by RNA-binding proteins encoded in the nuclear genome termed org...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. Th...

Abstract The MIME-seq2.0 technique utilizes a chimeric methyltransferase engineered to bind Argonaute proteins (hereafter referred to MIME enzyme) to protect the terminal sugar of small non-coding RNAs (sncRNAs) from oxi...

IntroductionMacrophages play a key role in inflammatory diseases. We aimed to identify long noncoding RNAs that regulate pro-inflammatory activation of human macrophages. MethodsWe performed human lncRNA microarray analy...

Abstract Vertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for s...

Abstract Background Single-cell RNA sequencing (scRNA-seq) is considered a revolution in gene expression studies and offers significant benefits across various fields of biomedical or clinical applications. However, a hi...

Abstract Inflammatory breast cancer (IBC) is characterized by congestion of dermal lymphovascular spaces by tumor emboli. We characterized expression of CCR7, a lymphocyte homing chemokine receptor, in IBC cell lines and...

Transient induction of a miRNA derived via lysosomal processing of 28S rRNA enables cells to distinguish between temporary mild stress and chronic stress that calls for a proinflammatory response. ER stress underlies num...

Abstract Laryngeal cancer (LC) is one of the malignant tumors affecting the head and neck region. 5-methylcytosine (m5C) is a common RNA modification that contributes to the carcinogenesis process. Aly/REF export factor ...

IntroductionIndividuals with obesity may be at a higher risk of developing severe periodontitis. We previously reported that C-C motif ligand 19 (CCL19) plays a pivotal role in adipose inflammation in obesity and that ad...

Abstract Background and purpose Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular e...