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36 resultados encontrados.

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Anti-aging Effect of Black Garlic Through Anti-senescence, Gelatinase Inhibition Mechanism, and Formulation of NLC Serum
Artículo
Material complementario disponible Artículo DOAJ
Anti-aging Effect of Black Garlic Through Anti-senescence, Gelatinase Inhibition Mechanism, and Formulation of NLC Serum
Fatiha Citra Effendi et al · Universitas Gadjah Mada · 2025 · ISSN 1410-5918
Aging associated with cellular senescence was responsible for the degradation of collagen and elastin by activation of matrix metalloproteinases (MMPs) that produced wrinkles. Black garlic is known to have an anti-aging ...
LCC LCC:MedicineIdioma eng
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Effects of hormonal and physical treatments on the expression of a putative chlorophyll b reductase gene (BoNYC1) during postharvest senescence of broccoli
Artículo
Acceso abierto Artículo CONICET Digital
Effects of hormonal and physical treatments on the expression of a putative chlorophyll b reductase gene (BoNYC1) during postharvest senescence of broccoli
Reyes Jara, Andrea Milagros et al · Elsevier Science · 2019 · ISSN 0925-5214
Senescence and degreening are the most important features that determine loss of quality during postharvest of broccoli. During senescence, chlorophylls are degraded with the purpose of avoiding presence of photoactive m...
Idioma eng
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Luteolin induces mitochondria-dependent apoptosis and senescence in myelodysplastic syndrome cells by targeting the Akt signaling pathway
Tesis
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Luteolin induces mitochondria-dependent apoptosis and senescence in myelodysplastic syndrome cells by targeting the Akt signaling pathway
LI Jiarun et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927
Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma zho
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Puerarin alleviates crystalline silica-induced pulmonary fibrosis by suppressing mtDNA leakage-induced senescence and EMT in alveolar type II cells
Artículo
Acceso abierto Artículo DOAJ
Puerarin alleviates crystalline silica-induced pulmonary fibrosis by suppressing mtDNA leakage-induced senescence and EMT in alveolar type II cells
Shuwen Gong et al · Elsevier · 2026 · ISSN 0147-6513
Silicosis, caused by inhalation of crystalline silica (SiO2), remains a serious and persistent public health concern. Puerarin (Pue), a bioactive isoflavone derived from Pueraria lobata, is known for its anti-inflammator...
LCC LCC:Environmental pollution; TENDOkVudmlyb25tZW50YWwgc2NpZW5jZXM~Idioma eng
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Solanum nigrum L.-derived nanovesicles as novel nanotherapeutics suppressing prostate cancer progression via senescence-based antitumor activity
Artículo
Material complementario disponible Artículo DOAJ
Solanum nigrum L.-derived nanovesicles as novel nanotherapeutics suppressing prostate cancer progression via senescence-based antitumor activity
Miao Gan et al · SpringerOpen · 2026 · ISSN 2197-4365
Abstract Current therapies for prostate cancer are limited by toxicity and acquired resistance, motivating development of biocompatible nanotherapeutics. Here, Solanum nigrum L.-derived nanovesicles (SDNVs) were isolated...
LCC TENDOlRlY2hub2xvZ3k~; TENDOkNoZW1pY2FsIHRlY2hub2xvZ3k~; TENDOkJpb3RlY2hub2xvZ3k~Idioma eng
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TMEM72 Inhibits the proliferation by promoting cellular senescence through the activation of the P38/MAPK signaling pathway in renal cell carcinoma
Artículo
Acceso abierto Artículo DOAJ
TMEM72 Inhibits the proliferation by promoting cellular senescence through the activation of the P38/MAPK signaling pathway in renal cell carcinoma
Fang Dai et al · Elsevier · 2026 · ISSN 1936-5233
Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy lacking reliable prognostic biomarkers and effective therapeutic targets. TMEM72, a kidney-enriched protein, is dysregulated in RCC, yet its bio...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway
Artículo
Material complementario disponible Artículo DOAJ
Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway
Yanyan Lin et al · Taylor & Francis Group · 2026 · ISSN 0785-3890
Background Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women wi...
LCC LCC:MedicineIdioma eng
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Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence
Artículo
Material complementario disponible Artículo CONICET Digital
Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence
Alvarez, María Soledad et al · Elsevier · 2014 · ISSN 0006-291X
Sterol regulatory element binding proteins (SREBP), encoded by the Srebf1 and Srebf2 genes, are important regulators of genes involved in cholesterol and fatty acid metabolism. Whereas SREBP-2 controls the cholesterol sy...
Idioma eng
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Fluxo de biomassa em pastagem de azevém anual (Lolium multiflorum Lam.) manejada em diferentes alturas Biomass flows in Italian ryegrass pastures (Lolium multiflorum Lam.) managed under different sward heights
Artículo
Acceso abierto Artículo DOAJ
Fluxo de biomassa em pastagem de azevém anual (Lolium multiflorum Lam.) manejada em diferentes alturas Biomass flows in Italian ryegrass pastures (Lolium multiflorum Lam.) managed under different sward heights
Laíse da Silveira Pontes et al · Sociedade Brasileira de Zootecnia · 2004 · ISSN 1516-3598
Em pastagem de azevém anual sob lotação contínua com ovinos, quantificaram-se os fluxos de biomassa no período de 02 a 20 de outubro de 1999. Os tratamentos consistiram de quatro alturas (5, 10, 15 e 20 cm) de manej...
LCC LCC:Animal cultureIdioma eng
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Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis
Artículo
Material complementario disponible Artículo DOAJ
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis
Jingxin Pan et al · Elsevier · 2026 · ISSN 0147-6513
Benzo[a]pyrene (BaP), a widespread environmental pollutant, has been increasingly implicated in the pathogenesis of chronic degenerative diseases. Environmental pollutants have recently been recognized as emerging risk f...
LCC LCC:Environmental pollution; TENDOkVudmlyb25tZW50YWwgc2NpZW5jZXM~Idioma eng
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Anticancer potential of Curcuma caesia: induction of DNA damage and apoptosis in cervical cancer
Artículo
Acceso abierto Artículo DOAJ
Anticancer potential of Curcuma caesia: induction of DNA damage and apoptosis in cervical cancer
Megha Radhakrishnan et al · BMC · 2026 · ISSN 2662-7671
Abstract Background Cervical cancer remains the fourth most common malignancy among women worldwide, with limited therapeutic success in advanced and recurrent stages. Conventional treatments, including radiotherapy and ...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng
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Association of accelerated biological aging with obstructive sleep apnea symptoms and identification of a candidate biomarker gene signature
Artículo
Material complementario disponible Artículo DOAJ
Association of accelerated biological aging with obstructive sleep apnea symptoms and identification of a candidate biomarker gene signature
Yixuan Wang et al · BMC · 2026 · ISSN 1868-7083
Abstract Background Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that is linked to cardiovascular, metabolic, and neurocognitive complications. However, its diagnosis relies on polysomnograp...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction
Artículo
Material complementario disponible Artículo DOAJ
Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction
Elena Mele et al · BMC · 2026 · ISSN 1475-2840
Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBjaXJjdWxhdG9yeSAoQ2FyZGlvdmFzY3VsYXIpIHN5c3RlbQ~~Idioma eng
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Biomass flow in massai grass fertilized with nitrogen under intermittent stocking grazing with sheep
Artículo
Acceso abierto Artículo DOAJ
Biomass flow in massai grass fertilized with nitrogen under intermittent stocking grazing with sheep
Marcos Neves Lopes et al · Sociedade Brasileira de Zootecnia · 2013 · ISSN 1516-3598
This study evaluated the biomass flow of massai grass in regrowth subjected to different nitrogen levels (control - no fertilization; 400; 800; and 1200 N kg ha-1year-1) and under rotational stocking with sheep, in a com...
LCC LCC:Animal cultureIdioma eng
Acceso abiertoRuta libre sin proxy. Acceso recomendado cuando no hay suscripción activa.
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Características morfogênicas e estruturais de capim-mombaça em três densidades de cultivo adubado com nitrogênio Morphogenic and structural characteristics of Panicum maximum Jacq. cv. Mombaça under three densities of fertilization with nitrogen
Artículo
Acceso abierto Artículo DOAJ
Características morfogênicas e estruturais de capim-mombaça em três densidades de cultivo adubado com nitrogênio Morphogenic and structural characteristics of Panicum maximum Jacq. cv. Mombaça under three densities of fertilization with nitrogen
Vinícius Valim Pereira et al · Sociedade Brasileira de Zootecnia · 2011 · ISSN 1516-3598
Objetivou-se com este trabalho avaliar o efeito da adubação nitrogenada e da densidade de plantas nas características morfogênicas e estruturais do capim-mombaça (Panicum maximum Jacq. cv mombaça). O experimento fo...
LCC LCC:Animal cultureIdioma eng
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Características morfogênicas e estruturais do capim-xaraés submetido à adubação nitrogenada e desfolhação Morphogenetic and structural characteristics of xaraésgrass submitted to nitrogen fertilization and defoliation
Artículo
Acceso abierto Artículo DOAJ
Características morfogênicas e estruturais do capim-xaraés submetido à adubação nitrogenada e desfolhação Morphogenetic and structural characteristics of xaraésgrass submitted to nitrogen fertilization and defoliation
Janaina Azevedo Martuscello et al · Sociedade Brasileira de Zootecnia · 2005 · ISSN 1516-3598
O trabalho foi realizado com o objetivo de se avaliarem as características morfogênicas e estruturais de Brachiaria brizantha cv. Xaraés, submetido a quatro doses de nitrogênio (0, 40, 80 e 120 mg/dm³) e três regim...
LCC LCC:Animal cultureIdioma eng
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Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer
Artículo
Acceso abierto Artículo CONICET Digital
Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer
Ramakrishnan, Swathi et al · Nature Publishing Group · 2017 · ISSN 2041-4889
Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherw...
Idioma eng
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Effect of foliar application of phosphites in "hayward" kiwifruit in storage and shelf life: analysis of pectin composition
Revista
Acceso abierto Revista CONICET Digital
Effect of foliar application of phosphites in "hayward" kiwifruit in storage and shelf life: analysis of pectin composition
Rivas Velasquez, Manuel de Jesus et al · Sociedad Argentina de Investigaciones Bioquímicas · 2019 · ISSN 0327-9545
The kiwifruit (Actinidia chinensis var chinensis cv. Hayward), a climacteric fruit, can be harvested at physiological maturity and maintain its quality for up to six months at cold storage. The length of the storage peri...
Idioma eng
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Excessive reactive oxygen species attenuated IL-17 production in CD161++ CD8+ T cell subset via repression of FOS in HIV-infected immunological non-responders
Artículo
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Excessive reactive oxygen species attenuated IL-17 production in CD161++ CD8+ T cell subset via repression of FOS in HIV-infected immunological non-responders
Jia-Qi Li et al · BMC · 2026 · ISSN 1478-811X
Abstract Background Immunological non-responders (INR), distinguished by profound immune dysfunction, fail to achieve immune reconstitution despite receiving antiretroviral therapy (ART). INR experience lower life expect...
LCC LCC:Medicine; LCC:CytologyIdioma eng
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Identification of a telomere-aging-related gene as a novel prognostic factor for intrahepatic cholangiocarcinoma: Machine learning-aided biomarker discovery and experimental verification
Artículo
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Identification of a telomere-aging-related gene as a novel prognostic factor for intrahepatic cholangiocarcinoma: Machine learning-aided biomarker discovery and experimental verification
Jianjian Yin et al · Elsevier · 2026 · ISSN 2472-6303
Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive hepatobiliary malignancy characterized by a complex pathogenesis and poor prognosis. Telomere dysfunction and cellular senescence are involved in the pat...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Karakterisasi Enam Galur Melon Daging Orange (Cucumis melo L.) di PT. Aditya Sentana Agro
Artículo
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Karakterisasi Enam Galur Melon Daging Orange (Cucumis melo L.) di PT. Aditya Sentana Agro
Siti Faizzatul Maghfirani et al · Lembaga Penelitian dan Pengabdian kepada Masyarakat · 2024 · ISSN 0216-9495
Efforts are made to produce superior seeds and pest and disease resistance through variety assembly. Characterization produces information that is used in planning the creation of melon plants as desired. This study aims...
LCC TENDOlRlY2hub2xvZ3k~Idioma eng
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Lipopolysaccharides Modulate Cellular Responses in Dental Pulp Cells
Artículo
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Lipopolysaccharides Modulate Cellular Responses in Dental Pulp Cells
Tanida Srisuwan et al · Wiley · 2026 · ISSN 1687-8736
Lipopolysaccharide (LPS) triggers signal transduction in dental pulp cells (DPCs), leading to various biological events. The present study described the biological response of DPCs to LPS, aiming to provide a deeper unde...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Morphogenetic and structural characteristics of xaraes palisadegrass submitted to cutting heights Características morfogênicas e estruturais do capim-xaraés submetido a alturas de corte
Artículo
Acceso abierto Artículo DOAJ
Morphogenetic and structural characteristics of xaraes palisadegrass submitted to cutting heights Características morfogênicas e estruturais do capim-xaraés submetido a alturas de corte
Braulio Maia de Lana Sousa et al · Sociedade Brasileira de Zootecnia · 2011 · ISSN 1516-3598
The objective of this work was to evaluate the morphogenetic and structural characteristics of xaraes palisadegrass submitted to three cutting heights (15, 20 and 25 cm) when the sward reached 95% of light interception d...
LCC LCC:Animal cultureIdioma eng
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