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Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this ...

Abstract Background The combined prognostic role of skeletal muscle index (SMI), subcutaneous fat index (SFI), and visceral fat index (VFI) in non-metastatic non-small cell lung cancer (NSCLC) remains unclear. Methods Co...

Abstract Although intravenous lipid emulsions are routinely administered to preterm infants, their specific effects on skeletal muscle development remain unclear. In this study, a soybean oil‐based lipid emulsion (Intr...

Abstract A decrease in resting muscle O2 uptake (V̇O2m) described during bed rest (BR) could determine a decreased whole‐body resting energy expenditure (REE), potentially useful during prolonged spaceflights. Two gro...

ABSTRACT Understanding how skeletal muscle influences bone formation is essential for uncovering the mechanisms of muscle‐bone communication and developing therapies for osteoporosis. Here, we demonstrate that extracel...

Bangle belongs to the ginger family and has anti-inflammatory properties; however, its efficacy against skeletal muscle atrophy in ulcerative colitis (UC) remains unexplored. This study investigated the effects of Bangle...

ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular med...

Materias / palabras clave: intramuscular fat; muscle ultrasound; predictive modelling; statistical methods

Abstract Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promote muscle growth in humans, including to counter the muscle lo...

ABSTRACT A detailed analysis of how muscle fiber nuclei (myonuclei) respond to a hypertrophic stimulus could provide a critical step toward understanding compromised skeletal muscle plasticity with age. We used recombina...

Abstract Background Denervation triggers dramatic atrophy of skeletal muscle, accompanied by synaptic, contractile and metabolic changes. Several factors were shown to contribute to genetic reprogramming and proteostasis...

Ageing and obesity are major public health issues, both associated with reductions in muscle mass, strength, and physical performance. Muscle quality, which integrates the morphological and functional characteristics of ...

IntroductionAdrenal incidentalomas are an increasing clinical concern and, while most are non-functioning adrenal adenomas (NFAA), a relevant subset is associated with mild autonomous cortisol secretion (MACS), condition...

ABSTRACT Background Physical exercise is recommended for sarcopenia prevention and treatment. Patients with frailty often show poor tolerance. To achieve universal availability, electrical stimulation of skeletal muscles...

Creatine kinase (CK) is an enzyme that plays a pivotal role in various physiological processes, including metabolism and muscle function. This enzyme is found in high concentrations in skeletal muscle and the myocardium,...

Abstract Erythropoietin (EPO) administration stimulates haematological and non‐haematological adaptations that alter substrate oxidation and enhance aerobic performance. The effects of strenuous exercise and EPO on met...

Introduction: Insulin resistance and type 2 diabetes mellitus are serious global health challenges, which are caused by aging population, increasing levels of obesity and insufficient amount of physical activity. Althoug...

BackgroundSarcopenia is a progressive, age-associated condition marked by loss of muscle mass, strength, and physical performance, representing a key nutritional and functional problem in aging people. This study examine...

Abstract Background Neuromuscular electrical stimulation (NMES) delivered transcutaneously activates skeletal muscle; its effectiveness is determined by stimulation parameters and by how skin-applied currents recruit und...

Abstract Background Myosin heavy chain (MyHC)-related congenital myopathies display variable age of onset and clinical manifestations depending on the mutated isoform. Cardiomyopathy, ophthalmoplegia and primarily proxim...

Background and objectivesPostoperative recurrence after percutaneous transforaminal endoscopic decompression (PTED) for degenerative lumbar spinal stenosis (DLSS) remains a clinically relevant challenge, complicating pre...

Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

BackgroundGlobal population aging is accelerating, and China faces a significant challenge with “aging before affluent.” The disabled older adults population in China is projected to reach 58 million by 2050. Early i...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...