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Abstract Chimeric antigen receptor macrophage (CAR-M) therapy has emerged as a highly promising novel platform in solid tumor immunotherapy. Leveraging its inherent tumor-homing capacity, potent phagocytic function, and ...

Abstract This multicenter, first-in-human Phase 1 study (NCT04956640) evaluated olomorasib (LY3537982), a next-generation KRAS G12C inhibitor designed to enhance target occupancy at low absolute exposures. In total, data...

Background: Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell d...

BackgroundSolid pseudopapillary tumors (SPTs) of the pancreas are rare, low-grade malignancies that generally have favorable outcomes when diagnosed at an early stage and can be resected. However, treatment options for p...

Background: ERBB2 aberrations are established oncogenic drivers with validated therapeutic relevance in breast cancer and emerging indications across solid tumors. In gastrointestinal malignancies, the prevalence, molecu...

Almost ten percent of the patients with highturnover uremic bone disease have brown tumors. We present here a 63-year-old male patient, on regular hemodialysis for twelve years, with subcutaneous tumoral masses appeared ...

Objetivos: avaliar aspectos clínicos e ultra-sonográficos de tumores pélvicos na pós-menopausa e correlacioná-los com o diagnóstico final. Pacientes e Métodos: foram seguidas prospectivamente 36 mulheres menopausa...

Abstract Immune system dysregulation is implicated in a wide range of human diseases, including cancer. Genetic studies have shown evidence of a link between immune diseases and cancer; therefore, deficits of immune syst...

BackgroundSevere oral complications during and after antineoplastic therapies, such as mucositis, fungal, viral, and bacterial infections, xerostomia, dysphagia, and jaw osteonecrosis, significantly impair oral health an...

Abstract Background Sarcoid tumors are common in horses and may negatively impact the performance and value of the horse. No known treatment is reliably successful. Hypotheses/Objectives To determine tolerability, overal...

Abstract Chimeric antigen receptor (CAR) T cell therapies have achieved clinical success in autologous treatment of hematological malignancies. However, their broader application remains limited. Beyond the biological ch...

Abstract Background Small cell carcinoma of the ovary (SCCO) is a rare, highly aggressive malignancy comprising pulmonary type (SCCOPT) and hypercalcemic type (SCCOHT). Clinical presentations are nonspecific, and CT feat...

Cancer-associated fibroblasts (CAFs) are one of the main components of the tumor microenvironment (TME) of solid tumors. They have several functions, which all contribute to tumor growth and immune evasion. CAF presence ...

Malignant solid tumors of the gastrointestinal tract are clinically rare in children, with malignant solid tumors of the esophagus being particularly uncommon. Clinical reports on esophageal cancer in children are extrem...

Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progres...

BackgroundTreatment of childhood cancer is associated with a substantial risk of life-threatening complications that may require admission to a pediatric intensive care unit (PICU). Data describing clinical characteristi...

Creatine kinase (CK) is an enzyme that plays a pivotal role in various physiological processes, including metabolism and muscle function. This enzyme is found in high concentrations in skeletal muscle and the myocardium,...

BackgroundAlthough the association between disorders of immunity and cancer risk is recognized, the prevalence of different malignancies in this population remains incompletely characterized. Large electronic health reco...

Abstract Anti-angiogenic agents are widely used to treat solid tumors. We previously demonstrated that nicorandil, an angina pectoris medication, counteracted the effects of bevacizumab in a human mini-tumor model. To fu...

Abeer Abdulhadi Alhuthali,1 Abdullah Alshammari,2 Athar Yosuf Jaha,2 Alaa Shahbar,2 Lama Mohammed Almilaibi,3 Reem Saeed Alwadie,2 Alanoud Naher Alghanmi,3 Manal Aljohani,4 Abdullah F Alharthi,5 Mohammed Alnuhait5 1Depar...

Immune checkpoint inhibitors (ICIs) have been widely utilized in patients with cancer and established as a standard therapeutic modality for various solid tumors. Although generally well tolerated, ICIs can induce unique...

Antibody-drug conjugates (ADCs) combine the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads. In recent years ADCs have emerged as a clinically validated component of mode...

Background/ObjectiveCisplatin is a popular platinum-containing chemotherapeutic agent that has been used clinically since the 1970s to manage a wide range of hematologic and solid tumors. However, its therapeutic purpose...

γδ T cells in human solid tumors remain poorly defined. Here, we describe molecular and functional analyses of T-cell receptors (TCRs) from tumor-infiltrating γδ T lymphocytes (γδ TILs) that were in direct contact ...