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IntroductionVirtual control groups (VCGs) are proposed as a means to reduce reliance on live animals in preclinical toxicology studies. Despite the potential benefits of VCGs, concerns remain regarding their comparabilit...

Benzo[a]pyrene (BaP), a widespread environmental pollutant, has been increasingly implicated in the pathogenesis of chronic degenerative diseases. Environmental pollutants have recently been recognized as emerging risk f...

Abstract The role of Bisphenol A (BPA) in endometrial cancer (EC) remains uncertain. In this study, we integrated toxicological prediction, network toxicology, gene expression profiling, survival analysis, and molecular ...

Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcri...

Triclosan (TCS) is widely applied to daily necessities as a chemical bacteriostatic agent. Environmental TCS levels have increased significantly following the coronavirus disease 2019 pandemic, posing a potential threat ...

Background The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses...

Tire and Road Wear Particles (TRWP) are pervasive environmental contaminants, yet the molecular mechanisms linking their toxic derivative, 6PPD-quinone (6PPD-Q), to bladder cancer (BLCA) progression remain obscure. This ...

Abstract Humans are exposed to thousands of chemicals throughout their life. Many of these chemicals are detected in blood and have been catalogued in the Blood Exposome Database. Comprehensive hazard assessment of a che...

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be a...

Secondary poisoning with anticoagulant rodenticides (ARs) has been identified as an important threat for raptor conservation worldwide. In 2019, the California State Legislature passed Assembly Bill 1788 (made effective ...

Background: Adolescence is a critical period of maturation when nutrient needs are high, especially among adolescents entering pregnancy. Using individual-level data from 140,000 participants, we examined socioeconomic, ...

IntroductionCurrent regulatory neurotoxicity guidelines do not include behavioral endpoints that capture stress-related responses. Zebrafish larvae prior to independent feeding offer a promising vertebrate model for deve...

A atividade cicatrizante de ferida do Sanativo® (SAN) e os possíveis efeitos tóxicos da sua administração subcrônica foram avaliados em ratos. O SAN reduziu significativamente a área das feridas abertas no dorso d...

Realizou-se a avaliação toxicológica do fitoterápico Propovit Plus® em roedores. Os testes agudos não produziram mortalidade, com DL50 acima de 5 g/kg (oral) e 2,5 g/kg (i.p.), mas encontrou-se diminuição no peso...

Os efeitos do óleo extraído das sementes da Carapa guianensis (OS) foram investigados sobre variáveis reprodutivas e desenvolvimento da prole de ratas Wistar. Quatro grupos de fêmeas foram tratados per os com OS (0,3...

Rorippa nasturtium-aquaticum (watercress) is recognized as a nutritious plant, rich in vitamins and minerals and it is used in the treatment of many illnesses. The aim of the present work was to develop a genotoxic ana...

Metronidazole (MTZ) is a wonderful drug, which is used clinically to treat a wide range of bacterial and protozoal infections. This study aimed to achieve a precise characterization of the cytotoxic and genotoxic activit...