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Team science is central to clinical and translational research; however, systematic evaluation of collaborative efforts remains inconsistent and underdeveloped. To better understand current team science evaluation practi...

Background: Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of chromatin...

Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...

Sarfaraz K Niazi Department of Pharmaceutical Sciences, University of Illinois, Chicago, IL, 60612, USACorrespondence: Sarfaraz K Niazi, Email sniazi3@uic.eduAbstract: Quantum technologies—quantum computing, quantum se...

Background and aims Meat-borne Staphylococcus aureus (S. aureus) remains a leading global foodborne pathogen harbouring novel enterotoxin genes (NEGs) encoding superantigenic toxins with conditionally enhanced pathogenic...

S-palmitoylation, a key reversible lipid post-translational modification, entails the covalent conjugation of palmitic acid chains to the thiol groups of cysteine residues in proteins. This modification modulates protein...

Objective This study evaluated real-world engagement with the online Military to Civilian Adjustment and Reintegration Measure (M-CARM) platform, described user characteristics and usage patterns, and examined score dist...

Small sample sizes in preclinical research limit the extraction of reliable knowledge and hinder translational progress. We propose genESOM, a generative artificial intelligence method based on emergent self‑organizing...

Abstract Background Knee osteoarthritis (OA) is a leading global cause of disability, yet conventional tools lack sensitivity for early detection and precise prognostication. Artificial intelligence (AI) and machine lear...

Si-Hang Wang,1 Si-Zhe Li,1 Yi-Ran Li,2 Jie Zhang,1 Yan Wang,1 Ya-Gang Zuo1 1Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of M...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Abstract Purpose This study introduces a new Convolutional Neural Network (CNN) architecture, EyeDiagNet, for the classification of fundus images into four classes: normal, cataract, diabetic retinopathy (DR), and glauco...

BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...

PurposeImmune dysregulation and neuroinflammation have been increasingly implicated in depression, and nanotechnology-based approaches are being actively explored for targeted delivery and immunomodulation. However, a sy...

IntroductionDNGR-1 (CLEC9A), a C-type lectin receptor specifically expressed on human BDCA3+ and murine CD8α+/CD103+ conventional type 1 dendritic cells (cDC1), acts as a damage-associated molecular pattern (DAMP) recep...

ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and...

Abstract The use of animal-borne devices to measure acceleration has yielded insights into animal locomotion, behaviour and energy expenditure. We present the first systematic review of accelerometry on animals, spanning...

ABSTRACT In this paper, we develop a photothermal‐responsive hydrogel (CNB‐ePRP) based on engineered platelet‐rich plasma (PRP)/sodium alginate (SA) hydrogel integrating thrombin‐functionalized composite nanobott...

Phosphorylated non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9; GAPN) found in heterotrophic cells of wheat is activated by MgCl2. The divalent cation disrupts the interaction between GAPN and a ...

The major glycoproteins of bovine gammaherpesvirus 4 (BoHV-4) are gB, gH, gM, gL, and gp180 with gB, gH, and gp180 being the most glycosylated. These glycoproteins participate in cell binding while some act as neutraliza...

Diabetic kidney disease (DKD) is one of the most severe complications of diabetes. Animal models of DKD play a crucial role in elucidating disease pathogenesis, exploring therapeutic strategies, and developing pharmacolo...

ABSTRACT Introduction Antimicrobial resistance (AMR) is a global health crisis that poses a devastating and specific threat to immunocompromised cancer patients, who are heavily reliant on antibiotics to navigate high‐...

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic p...