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37 resultados encontrados.

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Comparative evaluation of Bayesian external information borrowing and frequentist approaches in underpowered confirmatory trials
Artículo
Material complementario disponible Artículo DOAJ
Ruobing Li et al · BMC · 2026 · ISSN 1471-2288
Abstract The application of Bayesian statistics in pivotal clinical trials has gained increasing attention, particularly for underpowered confirmatory trials such as those in pediatric and rare disease populations. Bayes...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Impact and Perspectives of Registry-Based Research in Inborn Errors of Immunity/Primary Immune Disorders: Insights from the ESID Registry of 36,681 Patients
Artículo
Acceso abierto Artículo DOAJ
Markus G. Seidel · Rockefeller University Press · 2026 · ISSN 3065-8993
Clinical research and real-world observational studies are essential for advancing the diagnosis and treatment of rare diseases, such as inborn errors of immunity/primary immune disorders (IEI/PID). To support efficient ...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Open Access
Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?
Artículo
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Dimana Dimitrova et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Hematopoietic cell transplantation (HCT) offers curative potential for inborn errors of immunity (IEI) patients, who often enter HCT with significant comorbidities and disease sequelae, active infections, and/or limited ...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Manufacturing Process Simulation – On Its Way to Industrial Application
Artículo
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Dennis Otten et al · Embry-Riddle Aeronautical University · 2018 · ISSN 2374-6793
Manufacturing process simulation (MPS) has become more and more important for aviation and the automobile industry. A highly competitive market requires the use of high performance metals and composite materials in combi...
LCC LCC:Motor vehicles. Aeronautics. AstronauticsIdioma eng
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Open Access
Internal standard-assisted ab initio MD simulation for comparative thermal stability and decomposition mechanisms of energetic materials
Artículo
Acceso abierto Artículo DOAJ
Ying Xiong et al · KeAi Communications Co. Ltd · 2026 · ISSN 2666-6472
Thermal stability is one of the most important and fundamental properties of energetic molecules, and still suffers from many challenges in theoretical evaluation prior to experiment determination. This work introduces a...
LCC TENDOkNoZW1pY2FsIHRlY2hub2xvZ3k~Idioma eng
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Modulation of feedback-related negativity by objective and subjective response correctness
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Yasuhisa Maruyama et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Monitoring actions and outcomes is essential for flexible adaptation to environmental demands. Information about errors is important regardless of whether it is internally generated or externally signaled. Follo...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Perceptual–motor performance and neural conduction asymmetries in elite basketball players
Artículo
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Meltem Devrilmez et al · BMC · 2026 · ISSN 2052-1847
Abstract Background This study investigated whether the dominant hand would exhibit faster nerve conduction velocity, lower muscle activation latency, and superior Coincidence Anticipation Timing (CAT) performance compar...
LCC TENDOlNwb3J0cyBtZWRpY2luZQ~~Idioma eng
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Quantum Computing and Quantum Technologies in Drug Discovery and Therapeutics: Evidence, Benchmarking, and Translational Integration
Artículo
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Niazi SK · Dove Medical Press · 2026 · ISSN 1177-8881
Sarfaraz K Niazi Department of Pharmaceutical Sciences, University of Illinois, Chicago, IL, 60612, USACorrespondence: Sarfaraz K Niazi, Email sniazi3@uic.eduAbstract: Quantum technologies—quantum computing, quantum se...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Open Access
Integrated FEA framework for chassis design and failure prediction in SAE supra vehicles
Artículo
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Bobby Kurian Samson et al · EDP Sciences · 2026 · ISSN 2100-014X
This paper will offer a unified strategy to the optimization of the chassis of a Formula SAE Supra car and predict structural failures using machine learning and Finite Element Analysis (FEA). The work demonstrates that ...
LCC TENDOlBoeXNpY3M~Idioma eng
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The evolution of projectile points and technical systems: A case from Northern Patagonian coast (Argentina)
Artículo
Acceso abierto Artículo CONICET Digital
Cardillo, Marcelo et al · Elsevier · 2014 · ISSN 2352-409X
In this paper we present the results of the phylogenetic analysis of projectile points dating from the Middle-Late and final Late Holocene recovered from different sites along the coast of San Matías Gulf (Río Negro pr...
Idioma eng
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Open Access
ADAM: advanced design and AI-driven modeling for plant tissue culture media optimization
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Hans Bethge et al · BMC · 2026 · ISSN 1746-4811
Abstract Background Optimization of biotechnological processes is traditionally limited by time-consuming trial-and-error approaches and the complexity of simultaneously optimizing multiple, often conflicting objectives....
LCC TENDOlBsYW50IGN1bHR1cmU~; LCC:Biology (General)Idioma eng
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Effects of repetitive peripheral magnetic stimulation on upper extremity motor function recovery after stroke: a meta-analysis and dose-response study
Artículo
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Liu Hui et al · Frontiers Media S.A · 2026 · ISSN 1664-2295
BackgroundRepetitive peripheral magnetic stimulation (rPMS), a representative non-invasive neuromodulation technique, is widely utilized for the recovery of motor dysfunction following stroke. Although its clinical effic...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Open Access
From empirical vaccinology to predictive systems-based vaccine design: multi-omics integration, artificial intelligence, and global equity challenges
Artículo
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Nicole Simone De Lima Coelho et al · Frontiers Media S.A · 2026 · ISSN 2674-0702
Although vaccination remains one of the most impactful interventions in contemporary public health, with consistent and widely documented reductions in morbidity and mortality, the traditional empirical development of va...
LCC TENDOlBoeXNpb2xvZ3k~Idioma eng
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Influence of rhythmic music game intervention on executive function and sensorimotor ability of children with attention deficit hyperactivity disorder
Artículo
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Honghui Zhu · Frontiers Media S.A · 2026 · ISSN 2296-2565
ObjectiveTo investigate the effectiveness of rhythmic music game–based intervention in improving executive functions and sensorimotor abilities among children with Attention-Deficit/Hyperactivity Disorder (ADHD), there...
LCC LCC:Public aspects of medicineIdioma eng
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Psicologia jurídica e tomada de decisão em situações envolvendo abuso sexual infantil Forensic psychology and decision making in situations involving child sexual abuse
Artículo
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Cátula Pelisoli et al · Universidade de São Francisco, Programa de Pós-Graduação Stricto Sensu em Psicologia · 2011 · ISSN 1413-8271
Este trabalho apresenta uma revisão teórica sobre a tomada de decisão em situações de alegação de abuso sexual infantil. Profissionais de saúde mental em todo o mundo necessitam tomar decisões acerca da veracida...
LCC TENDOlBzeWNob2xvZ3k~Idioma eng
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Technology‐based and digital interventions for intimate partner violence: A systematic review and meta‐analysis
Artículo
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Chuka Emezue et al · SAGE Publishing · 2022 · ISSN 1891-1803
Abstract Background A growing body of research shows the promise and efficacy of technology‐based or digital interventions in improving the health and well‐being of survivors of intimate partner violence (IPV). In ad...
LCC TENDOlNvY2lhbCBTY2llbmNlcw~~Idioma eng
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Use of Sirolimus and Immunoglobulin Replacement Therapy (IRT) in Patients with Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS): A Systematic Literature Review (SLR)
Artículo
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Nicholas L. Hartog et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionActivated Phosphoinositide 3-Kinase Delta Syndrome (APDS), a rare inborn error of immunity, is associated with immunodeficiency and immune dysregulation. Clinical management includes symptomatic treatment wit...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Factors Affecting Dimensional Precision of Consumer 3D Printing
Artículo
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David D. Hernandez · Embry-Riddle Aeronautical University · 2015 · ISSN 2374-6793
This paper investigates the factors affecting dimensional precision of consumer-grade 3D printing, attempting to isolate and mitigate sources of error. The focus is on creating engineering prototypes of, tooling for, or ...
LCC LCC:Motor vehicles. Aeronautics. AstronauticsIdioma eng
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Application of the first canonical variable in the evaluation of animal production trials Aplicação da primeira variável canônica na avaliação de experimentos de desempenho produtivo com animais
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Acceso abierto Artículo DOAJ
Edenio Detmann et al · Sociedade Brasileira de Zootecnia · 2005 · ISSN 1516-3598
The objective of this work was to evaluate the inter treatment discrimination according to feed conversion efficiency in several animal performance experiments. The variables investigated were: feed conversion ratio (FCR...
LCC LCC:Animal cultureIdioma eng
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Leveraging artificial intelligence to improve data configuration & accuracy in modern flight management systems
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Sreeram Chittayil · Embry-Riddle Aeronautical University · 2024 · ISSN 2374-6793
AI (Artificial intelligence) can automate the process of generating optimized flight routes using real-time data, such as AIRAC (Aeronautical Information Regulation and Control), significantly reducing the time needed fo...
LCC LCC:Motor vehicles. Aeronautics. AstronauticsIdioma eng
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Predictive modeling of punchouts in continuously reinforced concrete pavement: a machine learning approach
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Ghazi Al-Khateeb et al · Springer Nature · 2025 · ISSN 2097-0943
Abstract The accurate prediction of the deterioration of Continuously Reinforced Concrete Pavement (CRCP) is essential for the effective management of pavements and the maintenance of infrastructure. In this study, a co...
LCC LCC:Engineering (General). Civil engineering (General); TENDOkluZm9ybWF0aW9uIHRlY2hub2xvZ3k~Idioma eng
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A multi-dimensional transformer encoder framework for modeling fine-grained student programming behavior
Artículo
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Grota Abdelkader et al · Springer · 2026 · ISSN 2948-2992
Abstract Learning to program is not just about writing code. It is a complex process involving trial and error, hesitation, corrections, and sometimes silence. And each student experiences it in their own way. Understand...
LCC LCC:Electronic computers. Computer scienceIdioma eng
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Designing photonic topological insulators with quantum-spin-Hall edge states using topology optimization
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Christiansen Rasmus E. et al · Wiley · 2019 · ISSN 2192-8606
Designing photonic topological insulators (PTIs) is highly non-trivial because it requires inversion of band symmetries around the band gap, which was so far done using intuition combined with meticulous trial and error....
LCC TENDOlBoeXNpY3M~Idioma eng
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Dynamic matching strategy for college students’ innovative training projects based on reinforcement learning optimization
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Xiao Ju et al · Springer · 2026 · ISSN 2731-0809
Abstract Matching college students with appropriate innovative training projects is a challenging task that often relies on static assignment techniques, which overlook individual interests, skills, and learning styles. ...
LCC TENDOkNvbXB1dGF0aW9uYWwgbGluZ3Vpc3RpY3MuIE5hdHVyYWwgbGFuZ3VhZ2UgcHJvY2Vzc2luZw~~; LCC:Electronic computers. Computer sciIdioma eng
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