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Abstract Importance The mortality benefit of lipid-lowering therapies (LLTs) in true primary prevention of cardiovascular disease (CVD) remains uncertain, in part because prior studies frequently included individuals wit...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

Oropharyngeal infection has long been associated with cardiovascular disease (CVD), specifically valvular disease and endocarditis. However, the relationship between periodontal disease (PD), with associated infection an...

The most common cause of death in patients with end-stage renal disease is cardiovascular (CV) disease. Vascular calcifi cation (VC) is a CV risk factor among dialysis patients. Advanced age, dialysis adequacy, vitamin D...

PURPOSE: To quantitatively evaluate the vascularity of the thyroid parenchyma in patients diagnosed with Hashimoto’s thyroiditis (HT) compared with healthy controls by using vascularity index (VI) through power Doppler...

Objective To explore the number of peripheral blood regulatory T cells (Treg) in patients with chronic kidney disease (CKD) and its correlation with vascular calcification. Methods This was a single-center, cross-section...

Abstract Background Vascular disorders of the intestine (VDI) and ischemic heart disease (IHD) are linked by shared atherosclerotic risk factors including diabetes, hypertension, and smoking. Their coexistence poses a si...

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Its complex pathogenesis remains unclear, and no specific drugs are available for treatment. Current treatments focus mainly on ...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...

Antiphospholipid antibodies can cause recurrent thrombotic attacks in some patients. Antiphospholipid antibodies are detected in patients with autoimmune disease especially systemic lupus erythematosus, infectious, malig...

IntroductionAge-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we investigated multivariate associative effects between modifiable vas...

BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, ther...

IntroductionSystemic juvenile idiopathic arthritis-associated lung disease (sJIA-LD) is a rare, potentially fatal complication of sJIA, often accompanied by pulmonary hypertension (PHTN) and macrophage activation syndrom...

Background Histologic features of pulmonary veno‐occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description. Objectives To report the ...

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with overall survival outcomes that have improved only modestly in recent years. Careful preoperative evaluation is essential for d...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...

The capillary wall of the glomerulus, which is composed of glomerular endothelial cells (GECs), the glomerular basement membrane (GBM), and podocytes, is responsible for the ultrafi ltration of plasma in the kidney. The ...

There are multiple receptors for vasopressin (ADH) named the V1a, V1b, and V2 receptors. The V2 receptors primarily mediate the antidiuretic response, while V1a and V1b receptors principally cause vasoconstriction and me...

BackgroundRetinal hemangioblastoma (RH) is a benign, highly vascularized tumor arising from the neurosensory retina. It may occur sporadically or as a manifestation of Von Hippel–Lindau (VHL) disease. Here, we describe...

Somayeh Haji Ahmadi, Shokouh Sadeghi Zadeh, Morteza Shahbandari, Mohammadreza Elhaie Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranCorrespondence: Mohammadreza Elhaie, ...

Vascular calcification arises from osteogenic transdifferentiation of vascular smooth muscle cells (VSMC) driven by disordered calcium signaling. Sarcoplasmic/ER calcium ATPase 2 (SERCA2) maintains intracellular calcium ...

Castleman disease (CD) is a rare lymphoproliferative disorder classified into unicentric and multicentric forms, with unicentric disease typically presenting as a localized and benign condition that can be difficult to d...