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BackgroundHMPV is a leading cause of pediatric lower respiratory tract infections, second only to respiratory syncytial virus in causing severe pneumonia in children. Its clinical presentation closely mimics other common...

Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive combined immunodeficiency marked by severe atopy, recurrent viral and bacterial infections, high immunoglobulin E, eosinophilia, and lymphopenia...

BackgroundLoss-of-function variants in magnesium transporter 1 (MAGT1) cause X-linked Immunodeficiency with Magnesium defect, Epstein-Barr virus infection, and Neoplasia (XMEN) disease through impaired glycosylation. The...

Abstract Introduction Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality among older adults. Limited information is available in Israel regarding RSV outcomes, particularly compared to influenz...

Immunosuppression from human immunodeficiency virus (HIV) or other comorbidities increases susceptibility to gastrointestinal infections such as Entamoeba histolytica and cytomegalovirus (CMV). Although each pathogen can...

Abstract Introduction Respiratory syncytial virus (RSV) is the leading cause of respiratory infections and hospitalization among infants and a major burden on pediatric emergency department (EDs). Nirsevimab has recently...

The Nipah virus (NiV) is a zoonotic pathogen known for causing severe illnesses in both animals and humans, including encephalitis and respiratory issues. In this study, we present a nonlinear system of ordinary differen...

Porcine circovirus-associated disease (PCVAD), caused by pathogenic porcine circovirus type 2 (PCV2), remains one of the most economically devastating diseases in the global swine industry, and the continued emergence an...

Abstract Background Chikungunya virus (CHIKV) infection can progress to severe clinical forms requiring intensive care. This study aimed to characterize adult patients admitted to intensive care units (ICUs) with CHIKV d...

Abstract Background Tick-borne encephalitis virus (TBEV, Orthoflavivirus encephalitidis) is an arbovirus of the family Flaviviridae. It is the etiological agent of tick-borne encephalitis (TBE), a severe disease affectin...

Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...

Oropouche fever, caused by Oropouche virus (OROV) and transmitted primarily by Culicoides midges, has historically been considered a neglected tropical disease characterized by an acute, self-limiting febrile illness and...

Orf virus causes infections in sheep and goats with lesions especially around muzzle and mouth. The disease is widespread, and most sheep-rearing countries are not free of infection. Disease is caused by ORF virus (ORFV)...

ABSTRACT Background and Aims Among Paramyxoviruses (PMVs), measles virus (MeV) and human parainfluenza virus (HPIV) are major contributors to respiratory tract infections worldwide. Despite recurrent outbreaks of MeV and...

Abstract Background Rabbit hemorrhagic disease virus (RHDV) type 2 (GI.2) is an emerging pathogen genetically distinct from classic RHDV (GI.1). It can infect young, wild, and even vaccinated rabbits, and may also contra...

Human papillomavirus (HPV) is the most common sexually transmitted infection in the U.S. and the primary cause of multiple anogenital and oropharyngeal cancers. Although HPV vaccination is effective, uptake remains subop...

ABSTRACT Background and Aim Blood transfusion is a vital and life‐saving procedure, saving millions of lives across the world every year. However, it also presents a significant risk of spreading transfusion‐transmis...

Abstract Influenza A virus (IAV) infections play a substantial role in human disease, hospitalization, and economic loss. In an effort to better understand the intracellular effects that IAV replication has on individual...

Nipah virus (NiV) is an emergent paramyxovirus that causes serious disease in humans and animals. Accurate quantification of neutralizing antibodies (nAB) against NiV is essential for vaccine development. The current sta...

BackgroundRSV infection affects mostly infants and induces a substantial economic and medical burden for our health care systems. To implement effective preventive strategies against RSV the knowledge about its distinct ...

Abstract Background During infection, alterations of the endothelium’s barrier function are multifaceted and virus-specific. Rubella virus (RuV) infection during pregnancy damages the endothelium in the placental and f...

Inborn errors of immunity (IEI) can manifest with neurological disorders, indicating genetic overlap between immune and nervous system diseases. However, neurological disorder genes are rarely screened systematically for...

Abstract Potato crops in Bangladesh are significantly threatened by viral diseases, underscoring the need for comprehensive virome profiling to inform sustainable management strategies. In this study, we employed high-th...

Abstract Background Interactions between SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) at the population level remain poorly understood. This study aimed to quantify potential interactions among thes...