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Fachgebiete / Stichwörter: Medicina; Oncología; General

Background: Glioblastoma (GBM) exhibits marked spatial heterogeneity. This study aimed to investigate the spatial distribution patterns and gene co-expression modules associated with epidermal growth factor receptor (EGF...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

Abstract Background Systemic inflammation and nutritional status are increasingly recognized as prognostic determinants in glioblastoma (GBM). The CRP–albumin–lymphocyte (CALLY) index integrates inflammatory and immu...

Abstract Objective Given the distinct intratumoral heterogeneity of glioblastoma (GB) and solitary brain metastasis (SBM), habitat-based radiomics derived from neurite orientation dispersion and density imaging (NODDI) m...

Abstract Glioblastoma Multiforme (GBM) remains one of the most challenging malignancies to treat due to its aggressive proliferation, resistance to apoptosis, extensive angiogenesis, and capacity to evade conventional th...

Glioblastoma Multiforme (GBM) represents tumors that develop in the Central Nervous System (CNS) with the highest malignancy, incidence and prevalence. Flavonoid therapy has been gaining strength as an altern...

Glioblastoma stem cells (GSCs) and residual tumor cells - which resist conventional therapies, drive disease recurrence, and contribute to the formation of an immunosuppressive tumor-immune microenvironment (TIME) - repr...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Glioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans, exhibiting very bad prognosis. Treatment with surgery, radiotherapy, and chemotherapy (mainly us...

Abstract Background Primary central nervous system lymphoma (PCNSL) can be differentiated from glioblastoma multiforme (GBM) using positron emission tomography (PET) with [18F]fluoro-2-deoxy-D-glucose (FDG). However, dif...

"Este proyecto se centra en el desarrollo de una herramienta de diagnóstico asistido por computadora (CAD) diseñada para apoyar a neurocirujanos, neurooncólogos y neurorradiólogos en la planificación quirúrgica y e...

Fil: Trebucq, Laura Lucia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Fil: Trebucq, Laura Lucia. Universidad de San Andrés. Laboratorio Interdisciplinario del Tiempo y la Experien...

En este trabajo se diseñó un método automático para la segmentación tridimensional del glioblastoma multiforme (GBM) con sus zonas internas de tumor activo, necrosis, y edema periférico difuso, combinando técnicas...

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and delet...

BACKGROUND: Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by a...

Glioblastoma is one of the most malignant brain tumors. Current treatments for glioblastoma usually make poor responses, and novel treatment strategies are extremely imperative. Cytochalasin E was reported to inhibit ang...

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to asses...