Akademische Ressourcen durchsuchen

Fachgebiete / Stichwörter: Medicina; Oncología; General

Background: Glioblastoma (GBM) exhibits marked spatial heterogeneity. This study aimed to investigate the spatial distribution patterns and gene co-expression modules associated with epidermal growth factor receptor (EGF...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

Abstract Background Systemic inflammation and nutritional status are increasingly recognized as prognostic determinants in glioblastoma (GBM). The CRP–albumin–lymphocyte (CALLY) index integrates inflammatory and immu...

Abstract Objective Given the distinct intratumoral heterogeneity of glioblastoma (GB) and solitary brain metastasis (SBM), habitat-based radiomics derived from neurite orientation dispersion and density imaging (NODDI) m...

Abstract Glioblastoma Multiforme (GBM) remains one of the most challenging malignancies to treat due to its aggressive proliferation, resistance to apoptosis, extensive angiogenesis, and capacity to evade conventional th...

Glioblastoma Multiforme (GBM) represents tumors that develop in the Central Nervous System (CNS) with the highest malignancy, incidence and prevalence. Flavonoid therapy has been gaining strength as an altern...

Glioblastoma stem cells (GSCs) and residual tumor cells - which resist conventional therapies, drive disease recurrence, and contribute to the formation of an immunosuppressive tumor-immune microenvironment (TIME) - repr...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Glioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans, exhibiting very bad prognosis. Treatment with surgery, radiotherapy, and chemotherapy (mainly us...

Abstract Background Primary central nervous system lymphoma (PCNSL) can be differentiated from glioblastoma multiforme (GBM) using positron emission tomography (PET) with [18F]fluoro-2-deoxy-D-glucose (FDG). However, dif...

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and delet...

BACKGROUND: Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by a...

Glioblastoma is one of the most malignant brain tumors. Current treatments for glioblastoma usually make poor responses, and novel treatment strategies are extremely imperative. Cytochalasin E was reported to inhibit ang...

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to asses...

Fachgebiete / Stichwörter: Medicine; Temozolomide; Radiation therapy; Concomitant; Internal medicine; Hazard ratio; Clinical endpoint; Oncology; Adjuvant; Cancer; Clinical trial; Surgery

Fachgebiete / Stichwörter: PDGFRA; Biology; IDH1; Transcriptome; Gene; Cancer research; Genome; Gene expression profiling; Somatic cell; Carcinogenesis; Genetics; Gene expression

Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite mul...

BackgroundGranular cell astrocytoma (GCA) is a rare, morphologically distinct variant of IDH-wildtype glioblastoma that can appear deceptively low-grade yet behave aggressively. Its molecular features remain poorly defin...

Abstract Locoregional CAR-T delivery is increasingly explored for glioblastoma to improve intracranial tumor exposure; however, organ-level biodistribution kinetics after intracranial administration remain poorly quantif...

Introduction: Gliomas represent the most prevalent form of brain tumors, among which glioblastomas are the most malignant subtype. Despite advances in comprehending their biology and treatment strategies, median survival...

Background: It has been demonstrated that relatively small variations of the parameters of exposure to extremely low frequency magnetic fields (ELF-MF) can change significantly the outcome of experiments. Hence, either i...