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Metabolic syndrome (MetS) is a pathologic multifaceted condition characterized by elevated triacylglycerides, decreased high density lipoproteins, insulin resistance, increased blood pressure and fasting glucose. Togethe...

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ABSTRACT Background and Aims Human metapneumovirus (hMPV) is a leading cause of acute respiratory tract infections, particularly in children, older adults, and individuals with immunocompromising conditions. Despite incr...

Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultim...

Trypanosoma cruzi elicits reactive oxygen species (ROS) of inflammatory and mitochondrial origin in infected hosts. In this study, we examined ROS-induced oxidative modifications in the heart and determined whether the r...

Toxoplasma gondii (T. gondii) is an apicomplexan parasite that infects most warm-blooded animals, including approximately one-third of the human population worldwide. Dense granule proteins (GRAs), secreted from speciali...

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a high incidence of renal involvement during its course contributing to disease morbidity and mortality. All compartments of the kidney may be affe...

Rosacea is a common dermatosis more prevalent in females, significantly impairing quality of life. Currently erythematous, papulo-pustular and phymatous subtypes are distinguished, which do not necessarily represent cons...

Abstract The research included extraction of siderophores from three pathogenic bacterial isolates: Escherichia coli ,Pseudomonas aeruginosa, Staphylococcus aureus isolated from urinary tract, burn, upper respiratory tra...

Systemic Lupus Erythematosus (SLE) is a prevalent disease that shows all the characteristics of an autoimmune pathology. The developments in the pathogenic factors in SLE provide new insights to the treatment of SLE and ...

Lupus erythematosus is an autoimmune disease characterized by complex immune disturbances concerning humoral and cell-mediated immune responses. Despite intensive research, many pathological processes regarding this diso...

Autosomal-dominant hyper-IgE syndrome (AD-HIES) is characterized by chronic mucocutaneous candidiasis, recurrent sinopulmonary pneumonias, noninflammatory atopic dermatitis, extremely high levels of serum IgE, and non-im...

Purpose. To identify specific risk factors and protective factors to inform tailored screening and management strategies for high-risk individuals. Methods. This case-control study included a total of 800 eyes from 400 i...

Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

Acne rosacea is a chronic inflammatory skin disease that affects the face. The symptoms depend on the stage of the disease. The first stage is characterized by erythema and telangiectasia. This is followed by a papulopus...

The aim of this review is to describe the main theoretical findings and research conclusions about obsessive-compulsive disorder (OCD) in the perinatal period. On one hand, epidemiological studies show that the risk of O...

BackgroundBehçet’s disease is a multisystem inflammatory disorder whose diagnosis can be challenging due to overlapping features with other inflammatory conditions and primary immunodeficiencies (1). In patients with ...

Reactive oxygen particles can increase tissue injury in the pathogenesis of human diseases. However, some antioxidants are used for therapeutic approach. In this review, the possible roles of reactive oxygen particles ...

Sepsis is a common and important cause of mortality in critically ill patients. Acute kidney injury (AKI) is one of the most important factors determining morbidity and mortality in this clinical picture. Recent studies ...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Abstract Industrialization and urbanization exacerbate global environmental health challenges, with pollutants from industrial and vehicular emissions (e.g., PAHs, NOx, PM2.5) posing significant risks. Growing evidence l...

To investigate the role and importance of iinmun system on the pathogenesis of uncomplicated RUTIs, 24 children with uncomplicated RUTIs (21 girls, 3 beys; age 5.81.0 years) were studied in the present study. Absolute ...

BackgroundThymoma, a neoplasm of the thymus, leads to hypogammaglobulinemia in ∼10% of affected patients, resulting in Good syndrome that frequently coexists with autoimmunity and mucosal candidiasis. Thymomas lose the...

Insulin-like growth factor 1 belongs to the group of polypeptide growth factors. It plays a special role in the regulation of pre- and postnatal growth of the organism, and also has a hypoglycaemic, neuro-, and osteo- an...