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The objective of the present study was to minimise the unwanted side effects of olanzapine (OZ) drug by kinetic control of drug release by entrapping into gastro resistant, biodegradable waxes such as beeswax (BW) micros...

"In this work, the peel of Arapey Sweet Potato (Ipomoea batatas), a vegetable waste, was used as a source of phenolic compounds which are widely recognized as beneficial antioxidants for human health. The extract obtaine...

Cymbopogon citratus essential oil (CCEO) is widely used in food, cosmetics and pharmaceutical fields. The aim of this study was to compare two different methods of encapsulating CCEO. The o/w emulsion method was employed...

The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan...

Nanoparticles are widely utilized to overcome drugs insolubility problems and sustain release improving the bioavailability. Zinc phthalocyanine, a hydrophobic photosensitizer with solubility problems, was loaded in PLA ...

Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more con...

"Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were cha...

"Chagas disease, caused by Trypanosoma cruzi, remains a major neglected disease with limited therapeutic options. Benznidazole (Bzn) is the first-line treatment, despite low aqueous solubility, poor bioavailability and s...

Nimesulide was formulated as sustained release microcapsules using biodegradable polymer Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation method. The prepared microcaps...

El objetivo del este estudio fue el desarrollo y la caracterización del microesferas de etilcelulosa contiendo diclofenaco y la determinación del perfil de la liberación del fármaco in vitro. Las microesferas fueron ...

The objective of the present investigation was to evaluate the potential of gellan gum- low molecular weight chitosan (GG-LMCH) polyelectrolyte complex (PEC) in the form of beads as prolonged release stomach specific flo...

Hydroquinone (HQ) is a drug reported to possess manifold biological activities. HQ is highly unstable into various topical vehicles, presenting low topical bioavailability and a relevant level of toxicity. The Pluronic®...

A simple and fast HPLC method has been validated for the determination of clotrimazole in nanocapsule suspensions prepared from an acrylic polymer, Eudragit RS100®. Chromatographic runs were performed on a RP C18 column...

This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model dr...

The development of functional composite materials is crucial for applications demanding the combination of complementary properties to achieve an enhanced performance. This study addresses a critical knowledge gap in the...

The present study involves the preparation of nimesulide-chitosan microparticles (NCM) as sustained delivery carriers with different polymer concentrations by pH change coacervation method using glutaraldehyde as cross-l...

The conventional method for preparing chitosan nanoparticles (CS-NPs) leads to the surface amino groups protonated and unable to link other useful moieties. In this study, we optimized the method of sodium chloride preci...

El objetivo del presente trabajo ha sido el de evaluar el efecto del peso molecular de acetobutirato de celulosa (ABC) (PM 30000 y 70000) y la presencia de polietilenglicol 1500 (PEG 1500) en el tamaño de microesferas p...

The objective of the present investigation was to investigate the effects of selected drugs (captopril and celecoxib) properties on different parameters drug entrapment, in vitro drug release, release pattern, in vitro d...

Oral route of drug administration is the most preferred route of drug administration but this route has its own limitations like pH of gastric media and controlling release rate of water soluble drug. To overcome these l...

The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various...

The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellul...

The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit...

Nobiliside A (Nob) is a new triterpenoid saponin first discovered and isolated from the Holothuria nobilis with chemical molecular structure of C54H87O26 SNa. Extracorporeal antitumor test showed that Nob may be a new ca...