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Cefuroxime axetil (CA) immediate release (IR) tablets were developed and optimized by direct compression method. Ten formulations were designed and optimized using central composite design with two main variables, microc...

The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various...

In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. ...

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasa...

The study aims to investigate a transdermal hydrogel formulation containing curcumin, which would attenuate the low bioavailability associated with oral administration of the drug. Carboxy polymethylene was used to devel...

The aim of the present investigation was to develop a modified release effervescent floating drug delivery system of famotidine for 12 h dosage regimen to improve its bioavailability. Effervescent floating tablets were...

The purpose of this study was to improve the meloxicam dissolution rate through its formulation into liquisolid compacts and then to evaluate the in vitro and in vivo performance of the prepared liquisolid compacts. Di...

The purpose of this work was to design and evaluate a novel vaginal delivery system for the local treatment of vaginal candidiasis. Bioadhesive vaginal films of metronidazole that could be retained in the vagina for prol...

The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit...

The objective of the present study was to develop an oral timed-released press-coated tablet containing theophylline as a model drug. A D-optimal design of experiment was employed to systematically study the effect of te...

Lipid-based nanocarriers were prepared by hot solvent diffusion technique. Tristearin (TS) and/or castor oil were employed as oily phase, and Lutrol F68® or Solutol HS15® and lecithin were employed as surfactant and co...

Subjects / keywords: Ciencias Sociales; General

"Discrete Fracture and Matrix (DFM) models describe fractured porous media as complex sets of 2D planar polygons embedded in a 3D matrix representing the surrounding porous medium. The numerical simulation of the flow in...

A new, simple, precise, sensitive and low-cost spectrophotometric method for methyldopa (MTD) determination in pharmaceutical preparations is described. This method is based on the reduction reaction of the free radical,...

The poly herbal formulations containing ginger are widely used for different medicinal properties. The present paper deals with the development of densitometric method for fingerprint of ginger mainly using 6-gingerol in...

The aim of this study was to evaluate the in vivo behavior of matrix tablets formulated with ketoprofen as a model drug after oral administrations in healthy Malaysian male volunteers and to compare its rate and extent o...

The objective of the present investigation was to investigate the effects of selected drugs (captopril and celecoxib) properties on different parameters drug entrapment, in vitro drug release, release pattern, in vitro d...

The aim of this study was to analyze the effects of formulations containing DMAE pidolate and DMAE acetoamidobenzoate on the skin. Four areas of five swines were submitted to following treatments during 15 days: C (Contr...

The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. T...

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence ...

Hydrophilic matrix tablets were developed with acyclovir (ACV), using hypromelose and polyethylene oxide (PEO) in different concentrations. Matrix tablets obtained in each formulation were evaluated to determine the weig...

A self-emulsifying drug delivery system (SEDDS) of a poorly water soluble drug, irbesartan (IRB), was designed. The aim was to improve the solubility as well as dissolution rates of IRB. Solubility of IRB in different ...

This study introduced a novel phase separation technique for the microencapsulation of metoprolol tartrate as a model. Non-solvent addition coacervation technique was employed for the loading of drug into ethylcellulose,...

Two liposomal formulations of doxorubicin (Caelyx® and Doxopeg®) were evaluated for phospholipid content, doxorubicin concentration, liposomal size, zeta potential, osmolarity, phospholipid peroxidation, in vitro relea...