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Con una edición bilingüe en castellano e inglés, este manual se ha realizado con la participación del PDI y del PAS de los Departamentos de Biología Vegetal, Botánica, Bioquímica, Biología Molecular, así como de...

Subjects / keywords: UNIVERSITY OF CALIFORNIA PRESS; 581.1 M718m

Abstract Background The efficacy of conventional αβ T cell-based immunotherapies is often limited by tumor immune evasion. γδ T cells can bypass these limitations through MHC-independent tumor recognition, but their ...

Abstract Chimeric antigen receptor (CAR) T cell therapies have achieved clinical success in autologous treatment of hematological malignancies. However, their broader application remains limited. Beyond the biological ch...

Adoptive therapy with CD19 chimeric antigen receptor (CAR) T cells is effective against B-cell malignancies; however, T-cell activation rapidly declines, increasing the risk of early leukemia relapses. To augment CD19 CA...

Actin remodeling is a critical regulator of mast cell secretion. In previous work, we have shown that dehydroleucodine and xanthatin, two natural α,β-unsaturated lactones, exhibit anti-inflammatory and mast cell stabil...

Impaired wound healing is one of the Diabetes mellitus complications. Low-intensity Pulsed Ultrasound (LIPUS) therapy may accelerate the impaired wound healing. The use of LIPUS therapy in the early inflammatory phase ca...

Pediatric cancer poses a major health challenge globally, especially in low-middle-income countries like Indonesia. The survival rate of pediatric cancer in many high-income countries (HICs) reaches 90%, while it only ra...

Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that detects microbial metabolites presented by the nonpolymorphic major histocompatibility complex (MHC)–like molecule MR1. Th...

Abstract Background Immune tolerance breakdown at the maternal-fetal interface is implicated in unexplained recurrent pregnancy loss (URPL), but the interplay between T cell hyperactivation and dendritic cells (DCs)-medi...

BackgroundMast cells are abundant throughout the lung, positioned near the airway epithelium, vasculature, and interstitium where they function as frontline sentinels to inhaled environmental and chemical stimuli. Throug...

Photodynamic priming (PDP), a collateral effect of photodynamic therapy, can transiently alter the tumor microenvironment (TME) beyond the cytotoxic zone. Studies have demonstrated that PDP increases tumor permeability a...

Objective: The study examined the effects of passengers’ conversations on adjacent passengers’ annoyance, attention to in-flight announcements, and performance on following instructions, which could lead to passenger...

BackgroundInterleukin-2–inducible T cell kinase (ITK) deficiency classically presents with EBV-driven lymphoproliferation and lymphoma, but emerging data suggest broader phenotypes of immune dysregulation. The pathogen...

BackgroundCongenital athymia (CA) is a rare T cell immune deficiency, fatal without curative treatment with allogeneic processed thymus tissue–agdc (RETHYMIC) implantation (here termed CTTI). The rate and extent of T c...

Abstract T cell states are prognostic in different cancer types. Recent technologies enable joint profiling of T cell RNA and T cell receptor (TCR) sequences at single-cell resolution. Here we present the TCR-RNA Integra...

BackgroundT cell–mediated hepatitis is an uncommon cause of acute pediatric liver injury. Most patients respond to steroids, but management of refractory disease remains challenging. We describe four patients with non-...

Subjects / keywords: Matemáticas; Aplicada

Current knowledge of the nervous system, particularly the brain, is the result of technological advances and the collective effort of many scientists. However, it was Santiago Ramón y Cajal (1852–1934) who played a cr...

Esta sonata para violonchelo solo, compuesta en dos movimientos, expande el universo introspectivo del ciclo Anatomía de la melancolía. El primer movimiento es un preludio que evoca de forma lejana el espíritu de las ...

La retina de los peces óseos, a diferencia de la retina de los mamíferos, posee células progenitoras multipotentes que proliferan a lo largo de toda la vida del animal, originando todos los tipos celulares retinianos,...

Abstract Cell-cultured meat, as a new type of meat food, can effectively mitigate the negative effects of conventional animal husbandry on the environment, health, and animal welfare. Muscle stem cells are the main seed ...

Leiyu Cao,* Xingfang Wei,* Yu Wei, Xiaoli Ma, Yan Gao, Chengcheng Qu, Wen Yi, Kalima Muhetaer, Li Zhang Cadre Healthcare Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinji...

Background: Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer with a steady increase in incidence. Purpose: This study aimed to confirm the role of LINC01583 on NSCLC progression and Osimertini...