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Abstract Background SPTBN1 encodes βII-spectrin, a cytoskeletal protein essential for neuronal structure and function. Pathogenic variants in this gene cause a neurodevelopmental disorder known as DDISBA (Developmental ...

Abstract Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure. We...

Background Equine motor neuron disease (EMND) is a neuromuscular disorder that affects adult horses. Although EMND has been linked to vitamin E deficiency, its etiopathogenesis is poorly understood. Objectives To describ...

M6a is a neuronal membrane glycoprotein whose expression diminishes during chronic stress. M6a overexpression in rat primary hippocampal neurons induces the formation of filopodial protrusions that could be spine precurs...

In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

Abstract Objective The study aimed to evaluate the hypoxia-induced brain injury and neuroprotective effects of pyrimidine and its derivative, arylvinylpyrimidine (AVP), in the freshwater catfish, Heteropneustes fossilis....

Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental drive...

Soluble amyloid-b peptide (Ab) oligomers, known to accumulate in Alzheimer´s disease brains, target excitatory post-synaptic terminals. This is thought to trigger synapse deterioration, a mechanism possibly underlying m...

Major depressive disorder (MDD) with suicidal ideation or behaviour (MDSI) is associated with an increased risk of future suicide. The timely identification of suicide risk in patients with MDD and the subsequent impleme...

The identification of suitable models for predicting daily water flow is important for planning and management of water storage in reservoirs of Argentina. Long-term prediction of water flow is crucial for regulating res...

Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced der...

Post-traumatic stress disorder (PTSD) is a severe neuropsychiatric disorder characterised by re-experiencing, avoidance and hyperarousal. Memory abnormalities manifested as intrusive thoughts and prolonged distressful em...

Purpose Retinoic acid (RA) has a critical role during development of the retina, controlling cell fate and differentiation. We here investigated RA effects on photoreceptor differentiation and apoptosis and the intrace...

Terahertz (THz) technology offers novel opportunities in biology and medicine, thanks to the unique features of THz-wave interactions with tissues and cells. Among them, we particularly notice strong sensitivity of THz w...

Maternal immune activation (MIA) can result from a variety of maternal inflammatory factors, including metabolic disorders, nutritional deficits, infections, and psychosocial stress. MIA has been consistently recognized ...

During postnatal development, the central nervous system (CNS) is highly sensitive to effects of drugs, stressors and environment. In this study, we evaluated the effect of acute cold stress on g-aminobutyric acid (GABA)...

Los sistemas tradicionales de odometría visual (VO), directos o basados en características visuales, son susceptibles de cometer errores de correspondencia entre imágenes. Además, las configuraciones monoculares sól...

Las diferencias entre sexos suelen ser un aspecto crucial a ser tenido en cuenta en ciertos desarrollos en neurociencias cognitivas. En el estudiode las redes neuronales de la atención (alerta fásica, vigilancia, orien...

Fil: Davies Sala, María Georgina. Fundación Instituto Leloir. Laboratorio de Plasticidad Neuronal; Argentina. El giro dentado del hipocampo es una de las dos regiones del cerebro de mamíferos adultos en las cuales se ...

Due to the increase in life expectancy, age-related neurodegenerative diseases (NDs) have become more prevalent. Conventional treatments fail to arrest or delay neuronal proteotoxicity that characterizes these diseases. ...

El aprendizaje de juegos ha motivado el desarrollo de numerosas estrategias de Inteligencia Artificial. Si bien existen diferentes enfoques, la adaptación al entorno de información es una característica deseable cuand...

"En el presente se detallan el diseño y desarrollo de un sistema informático para la ayuda en la toma de decisiones en el diagnóstico médico de la enfermedad COVID-19. Este sistema provee una herramienta que puede de...

En los últimos años, el área de la investigación y el desarrollo de los vehículos au- tónomos tuvo un gran auge debido a su impacto en los sectores económicos, culturales y ambientales. La detección y el seguim...