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IntroductionSystemic lupus erythematosus (SLE) in prepubertal children is rare and can indicate a monogenic cause. Although outcomes are variable, monogenic lupus is often difficult to treat with long-term complications ...

Abstract Mortality rates from breast cancer in young women have fallen considerably in high-income countries but continue to rise in low-income countries such as Morocco. Young women with breast cancer face unique challe...

Abstract Background Resistance to thyroid hormone (RTH) is a rare endocrine disorder, most commonly caused by mutations in the thyroid hormone receptor β (TRβ) gene, resulting in the RTH beta (RTHβ) subtype. In contra...

Abstract Background The prevalence and spectrum of PALB2 pathogenic/likely pathogenic variants (PV/LPVs) may vary across different regions, and these have not yet been analysed and reported in Slovenian HBOC families. Me...

Abstract Objective Describe the clinical course and diagnostic and genetic findings in a cat with X‐linked myotubular myopathy. Case Summary A 7‐month‐old male Maine coon was evaluated for progressively worsening g...

En el presente trabajo se describe el uso de un test no paramétrico para revalidar los resultados experimentales previos sobre el desempeño de cuatro técnicas de prueba de software. El mismo permite demostrar que, si ...

Mobile robot's navigation and obstacle avoidance in an unknown and static environment is analyzed in this paper. From the guidance of position sensors, artificial neural network (ANN) based controllers settle the desired...

As a new promising crossover method, multiple crossovers per couple (MCPC) deserves special attention in evolutionary computing field. Allowing multiple crossovers per couple on a selected pair of parents provided an ext...

As a new promising crossover method, multiple crossovers per couple (MCPC) deserves special attention in evolutionary computing field. Allowing multiple crossovers per couple on a selected pair of parents provided an ext...

The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot ...

Stewart C. Myers President of American Finance Association 1983 This paper's title is intended to remind you of Fischer Black's well-known note on “The Dividend Puzzle,” which he closed by saying, “What should the ...

Automated program repair often relies on syntactic transformations, generating large numbers of fix candidates whose correctness must be validated. Due to the combinatorial explosion of candidate combinations, existing t...

Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions. However, these met...

Abstract Rare disease gene discovery is limited by small cohorts and the frequent absence of matched controls. We present the Case-Only Burden Test (COBT), a gene-based burden test for case-only designs accounting for mu...

We announce the release of the fourth version of MEGA software, which expands on the existing facilities for editing DNA sequence data from autosequencers, mining Web-databases, performing automatic and manual sequence a...