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The Sequence of the Human Genome

Article

The Sequence of the Human Genome

J. Craig Venter; Mark D. Adams; Eugene W. Myers; Peter W. Li; Richard Mural; Granger G. Sutton; Hamilton O. Smith; Mark Yandell · Science · 2001

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months fr...

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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Article

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Erez Lieberman-Aiden; Nynke L. van Berkum; Louise Williams; Maxim Imakaev; Tobias Ragoczy; Agnes Telling; Ido Amit; Bryan R. Lajoie · Science · 2009

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genom...

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