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Friedreich's ataxia (FRDA) is linked to a deficiency of frataxin (FXN), a mitochondrial protein involved in iron-sulfur cluster synthesis. FXN is a small protein with an α/β fold followed by the C-terminal region (CTR)...

Subjects / keywords: PASINETTI, LUIGI LUDOVICO; CAMBRIDGE UNIVERSITY PRESS; 330.01 P282s

Nothing from the subsequent Augustan age can be fully explained without understanding the previous Triumviral period (43-31 BC). In this book, twenty experts from nine different countries and nineteen universities examin...

ABSTRACT Transition metal ions have been implicated in modulation the conformational behavior and aggregation of WT α‐synuclein (WT‐αSyn), associated with Parkinson's disease pathology. Nevertheless, the initial st...

Nonlinear response conception in rotating machinery, particularly in systems with squeeze film dampers (SFDs), pose significant challenges for established time-domain numerical methods due to bifurcations and critical po...

Spatiotemporal (ST) wave packets constitute a broad class of optical pulses whose spatial and temporal degrees of freedom cannot be treated independently. Such space-time non-separability can induce exotic physical effec...

Two-dimensional (2D) layered materials exhibit strong light-matter interactions, remarkable excitonic effects, and ultrafast optical response, making them promising for high-speed on-chip nanophotonics. Recently, signifi...

Modern agricultural systems face increasing uncertainties, rare risks, and complex dynamics that make traditional decision-making ineffective. This research presents an innovative digital twin–based framework for proac...

Abstract Continuous seismic data analysis identifies signals related to physical processes within the Earth or on its surface. Characterizing seismic signals yields insights into source processes and Earth's structural f...

Environmental conditions crucially influence species presence, distribution, population dynamics and phenology. Global warming and land use changes exacerbate these conditions, converting wetlands into terrestrial or aqu...

The conversion of solar radiation to chemical energy in plants and green algae takes place in the thylakoid membrane. This amphiphilic environment hosts a complex arrangement of light-harvesting pigment-protein complexes...

ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contribut...

The dimensions of mitochondria are close to the diffraction limit of conventional light microscopy techniques, making the complex internal structures of mitochondria unresolvable. In recent years, new fluorescence-based ...

Major depressive disorder (MDD) with suicidal ideation or behaviour (MDSI) is associated with an increased risk of future suicide. The timely identification of suicide risk in patients with MDD and the subsequent impleme...

Two-dimensional (2D) organic–inorganic perovskites have shown interesting optical properties due to the natural quantum-well structures. The repetition of soft organic and hard inorganic intercalations also renders 2D ...

ABSTRACT Background Health systems around the world are investing in learning health system (LHS) infrastructure to strengthen their capacity to adapt, improve, and respond in real time. While prior work has focused on t...

Subjects / keywords: Structural dynamics; Electronic books

Subjects / keywords: Structural dynamics; Structural design; Strength of materials; Electronic books

Ultrafast pulses, particularly those with durations under 100 fs, are crucial in achieving unprecedented precision and control in light–matter interactions. However, conventional on-chip photonic platforms are not in...