Chagas Disease
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Chagas Disease - Basic Investigations and Challenges
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Open AccessChagas Disease : Basic Investigations and Challenges
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Book
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Open AccessChagas Disease : From Cellular and Molecular Aspects of <i>Trypanosoma cruzi</i>-Host Interactions to the Clinical Intervention
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Open AccessControl of chagas disease vectors
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Article
Subjects / keywords: Medicina; Salud Pública
Idioma Spanish
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InstitucionalA highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen
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Article
Improved diagnostic tests for Chagas disease are urgently needed. A new lateral flow rapid test for Chagas disease is under development at PATH, in collaboration with Laboratorio Lemos of Argentina, which utilizes a reco...
Idioma English
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Open AccessCoupling ELISA to smartphones for POCT of chronic and congenital Chagas disease
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Article
Chagas disease (CD) affects about 7 million people worldwide, presents a large prevalence in Latin America, and is growing in the rest of the world, where congenital CD is the main mode of transmission. Point-of-care tes...
Idioma English
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Open AccessGenetic diversity of natural populations of Trypanosoma cruzi in clinical samples from patients with oral Chagas disease in Venezuela: Follow-up after treatment with trypanocidal drugs
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Journal
Oral transmission of Chagas disease (OChD) is an increasingly important aspect in the epidemiology. Venezuela has reported the two largest outbreaks described so far, affecting a total of 192 people mostly children. The ...
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Open AccessHuman Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease
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Article
Currently available drugs against Trypanosoma cruzi infection, which causes 12000 deaths annually, have limitations in their efficacy, safety and tolerability. The evaluation of thera-peutic responses to available and ne...
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Open AccessInput of NAcGlc6SO3 epitopes (sulfotopes) present in Trypanosoma cruzi glycoproteins, and their specific antibodies, in the infection and immune pathogenesis of experimental Chagas disease
Journal
Journal
Background: Trypanosoma cruzi, the causative agent of Chagas disease contains a major antigen, cruzipain (Cz). The C-terminal domain (C-T) of this glycoprotein bears N-linked high mannose type sulfated oligosaccharide ch...
Idioma English
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Open AccessPrevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.
Article
Article
Since the decline in new cases of infection by insect/vector, congenital Chagas disease has become more relevant in the transmission of Chagas disease. Treatment with benznidazole significantly reduces the parasitemia, w...
Idioma English
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Open AccessTrypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease
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Article
The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory profile caused by the interaction between T. cruzi and the host. R...
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Open AccessValidation of apolipoprotein A-1 and fibronectin fragments as markers of parasitological cure for congenital chagas disease in children treated with benznidazole
Article
Article
Background. No reliable tests or validated biomarkers exist to ensure parasitological cure following treatment of Chagas disease (CD) patients chronically infected with Trypanosoma cruzi. As seroreversion, the only marke...
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Open AccessCanine visceral leishmaniasis and Chagas disease among dogs in Araguaína, Tocantins
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Article
The present study analyzed serum samples from 111 male and female dogs of various ages from the municipality of Araguaína in the State of Tocantins, Brazil. Serological diagnosis of canine visceral leishmaniasis (CVL) w...
LCC LCC:Animal cultureIdioma English
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Open AccessCanine visceral leishmaniasis and Chagas disease among dogs in Araguaína, Tocantins Leishmaniose visceral canina e doença de Chagas em cães de Araguaína, Tocantins
Article
Article
The present study analyzed serum samples from 111 male and female dogs of various ages from the municipality of Araguaína in the State of Tocantins, Brazil. Serological diagnosis of canine visceral leishmaniasis (CV...
LCC LCC:Animal cultureIdioma English
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Open AccessLack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts
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Article
The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in four independent Latin Amer...
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Open AccessElucidating the impact of low doses of nanoformulated benznidazole in acute experimental Chagas disease
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Article
Fil: Rial, Marcela S. Ministerio de Salud. Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) “Dr. Carlos G. Malbrán”. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentin...
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Open AccessCardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis
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Article
Trypanosoma cruzi elicits reactive oxygen species (ROS) of inflammatory and mitochondrial origin in infected hosts. In this study, we examined ROS-induced oxidative modifications in the heart and determined whether the r...
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Open AccessPhylogenetic structure of geographical co-occurrence among New World Triatominae species, vectors of Chagas disease
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Article
The tropical niche conservatism (TNC) hypothesis is one of the most prominent evolutionary hypotheses that has been supported as an explanation for the diversity gradients of several animal taxa, mainly vertebrates. Howe...
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Open AccessGene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease
Article
Article
Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host?s signature ...
Idioma English
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Open AccessRecommendations for Multimodality Cardiac Imaging in Patients with Chagas Disease: A Report from the American Society of Echocardiography in Collaboration With the InterAmerican Association of Echocardiography (ECOSIAC) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DIC-SBC)
Article
Article
From Centro Medico de Caracas, San Bernardino, Caracas, Venezuela (H.A.); Medstar Washington Hospital Center, Washington, District of Columbia (F.M.A., R.M.); Socor Hospital, Belo Horizonte, Brazil (M.M.B.); Faculdade de...
Idioma English
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Open AccessCircadian entrainment by light and host in the Chagas disease vector, Triatoma infestans
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Article
Triatoma infestans (Reduviidae: Triatominae, "kissing bug") is the main insect vector of Trypanosoma cruzi, the causative agent of Chagas disease, a chronic trypanosomiasis infecting 10 million people world-wide. This he...
Idioma English
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Open AccessDevelopment and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?
Article
Article
Benznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many countries. However, its low water solubility produces low and/or variable oral bioavailability. Thus, the aim of this work was to formu...
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Open AccessFunctional characterization of the kinin receptor in the Chagas disease vector Rhodnius prolixus; activity of native kinins and potent biostable Aib-containing insect kinin analogs
Article
Article
The causative agent for Chagas disease, Trypanosoma cruzi, is transmitted to a human host in the urine/feces of the kissing bug, Rhodnius prolixus, following blood feeding. Kinins are important chemical messengers in the...
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Open Access