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Subjects / keywords: Medicina; Farmacología

The research on the synthesis of steroids and its derivatives is of high interest due to their clinical applications. A particular focus is given to molecules bearing a D-ring lactone like testolactone because of its bio...

Cladribine is a nucleoside analogue widely used in the pharmaceutical industry for the treatment of several neoplasms, including hairy-cell leukemia among others. This compound has also shown efficacy in the treatment of...

Oleanolic acid (1) is a bioactive compound widely distributed in nature. Microbial transformation is an effective way to alter the structures of compounds. The result of biotransformation of oleanolic acid was carried ou...

Rhizoma Paridis saponins (RPS) were considered to be the principal bioactive components of Paris polyphylla Smith var. yunnanensis. Intestinal microflora-mediated metabolism may affect their pharmacological activities in...

Subjects / keywords: No-ficción Adultos Jóvenes; Tecnología; Electricidad y Electrónica

Arsenic (As) is a toxic metalloid, and its accumulation in macroalgae has raised concerns for aquatic ecosystem health and human food safety given the increasing consumption of macroalgae. While previous studies have pre...

Eighteen (3R) and (3R,4R)-N-phenyl-, N-phenylalkyl and N-arylsuccinimides were prepared with high enantioselectivity by biotransformation of maleimides with A. fumigatus. This environmentally friendly, clean and economic...

Abstract Research on garlic peel has identified a variety of bioactive compounds. This study highlights the significance of garlic peels and the marine fungal strain Paecilomycesmaximus PQ584815 in generating secondary m...

The liver is the main place for phase II metabolism and transport of xenobiotics mediated by Mrp2, leading to elimination of conjugated metabolites into bile. In the gastrointestinal tract, phase II enzymes and Mrp2 are ...

Hyoscyamine, 6β-hydroxyhyoscyamine and scopolamine are anticholinergic agents that belong to the tropane alkaloids, a pharmacological important group of secondary metabolites. Hyoscyamine and scopolamine were historical...

ABSTRACT The melanomacrophage centers (MMCs) in the liver of fish are indicators of environmental conditions, as they are involved in xenobiotic biotransformation. The objective of this study was to evaluate the number o...

Quantification of polycyclic aromatic hydrocarbons (PAHs) in Bahía Blanca Estuary (BBE, Argentina) fish samples (Ramnogaster arcuata) was performed to evaluate the environmental impact through anthropogenic activity. In...

Punta Lara is located in the Río de la Plata estuary near industrial areas contaminated mainly by organic pollutants. In this work, the responses and status of hepatic biomarkers were studied in juvenile carp (Cyprinus ...

Abstract Background Tylosin is commonly prescribed to dogs with diarrhea. Orally administered antibiotics may alter the intestinal microbiota, which is responsible for crucial key bile acid (BA) biotransformation reactio...

The oral administration of macrocyclic lactones to sheep leads to poorer efficacy and shorter persistence of the antiparasitic activity compared to the subcutaneous treatment. Gastrointestinal biotransformation occurring...

This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-e...

Accelerating the composting of organic waste remains a key objective in research and practice. This review aims to critically examine recent advancements in microbial inoculation (MI) strategies and their role in enhanci...

Per- and polyfluoroalkyl substances (PFAS) are highly persistent environmental contaminants that pose potential ecological and health risks to humans and wildlife. This study investigated the comparative toxicity of four...

Abstract Arginine, an amino acid, is being increasingly widely applied in various fields, including cosmetics, pharmaceuticals, food, and agriculture. Arginine was produced from microbial fermentation of agro-industry ca...

La fisura labiopalatina no sindrómica (LL/PH) constituye una malformación congénita que presenta las características de una patología multifactorial; varios genes candidatos se han estudiado con el fin de describir ...

This study was performed to screen α-glucosidase inhibitors from the actinomycete metabolites library by high throughput screening. Twelve strains of actinomycete were considered to be α-glucosidase inhibitors producin...

A sensitive and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for the determination of tolbutamide (TB) and its metabolite hydroxytolbutamide (HTB) in rat plasma was developed using carba...