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The use of evolutionary and swarm intelligence algorithms, has become a very popular option to solve complex real-world optimization problems. However, in their original versions, these algorithms lack a mechanism to han...

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genom...

Subjects / keywords: Missing heritability problem; Heritability; Genome-wide association study; Genetic architecture; Genetic association; Biology; Genetics; Disease; Evolutionary biology; Computational biology; Data science; Genetic variant...

DNA-DNA hybridization (DDH) has been used for nearly 50 years as the gold standard for prokaryotic species circumscriptions at the genomic level. It has been the only taxonomic method that offered a numerical and relativ...

Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU ...