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The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasa...

The aim of the present investigation was to develop a modified release effervescent floating drug delivery system of famotidine for 12 h dosage regimen to improve its bioavailability. Effervescent floating tablets were...

The purpose of this study was to improve the meloxicam dissolution rate through its formulation into liquisolid compacts and then to evaluate the in vitro and in vivo performance of the prepared liquisolid compacts. Di...

A new reversible thermosensitive drug delivery system was designed and prepared by using chitosan and glycerophosphate with or without poly (ethylene glycol) and used as an a carrier for the Miconazole nitrate, an antifu...

Subjects / keywords: Ciencias Sociales; General

The nutritional value or quality of dietary proteins used for poultry feed formulation varies: amino acid availability is an important measure of protein quality. Determination of ileal digestibility values has become th...

The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double-blinded, controlled clinical t...

A self-emulsifying drug delivery system (SEDDS) of a poorly water soluble drug, irbesartan (IRB), was designed. The aim was to improve the solubility as well as dissolution rates of IRB. Solubility of IRB in different ...

This study introduced a novel phase separation technique for the microencapsulation of metoprolol tartrate as a model. Non-solvent addition coacervation technique was employed for the loading of drug into ethylcellulose,...

This study evaluated the effect of Cordia verbenacea essential oil (CV) and glycolic acid 70 % (GA), isolated and associated, on Wistar rats back skin. A base gel was added to 2 % of CV and/or 10 % of GA, thus forming ...

Subjects / keywords: BLALOCK, HUBERT M; PRINTICE-HALL; 519 B637t

The writer and political activist Victor Hugo proclaimed at the World Peace Congress held in Paris in 1849 that the death penalty must be abolished. Now, 176 years after that historic speech, a new objective is needed: t...

This book presents an introduction to the Finite Element Method (FEM) and is primarily aimed at students, engineers and scientists who already know structural calculation. It starts from the matrix reformulation of the d...

The efficacy of one or multiple doses of an injectable formulation of deslorelin (a GnRH agonist) was evaluated to induce estrus in anestrous bitches. Thirteen animals composed three groups: group 1 (n=5, single IM injec...

OBJETIVO: avaliar a efetividade e a segurança da administração de uma nova formulação de misoprostol em solução por via oral, com doses escalonadas, para indução do parto de feto vivo a termo. MÉTODOS: realizou...

The culmination of a lifetime of aesthetic investigation, Aesthetic Theory is Adorno's major work, a defense of modernism that is paradoxical in its defense of illusion. In it, Adorno takes up the problem of art in a day...

O objetivo deste estudo foi avaliar in vitro o efeito do óleo essencial de Thymus vulgaris (tomilho) puro ou incorporado em uma formulação farmacêutica de uso oral (enxaguatório bucal), frente ao Streptococcus mut...

The objective of this work was to develop a multivariate strategy to optimize tablet manufacturing employing mephenesin as model drug. The process variables for granulation step were binders and lubricants types, while ...

Neste estudo, comprimidos matriciais de captopril foram desenvolvidos utilizando-se hidroxipropilmetilcelulose (HPMC) e quitosana (QTS) em diferentes proporções (50:50, 60:40, 40:60, 20:80), por compressão direta. Os ...

The self-microemulsifying drug delivery system (SMEDDS) was employed to improve the bioavailability of sulpiride, a drug which is poorly soluble. The mean droplet size and emulsification time of the test formulation us...

The aim of the present study was to develop and evaluate chronomodulated rupturable pulsatile drug delivery of theophylline for the treatment of nocturnal asthma. Core tablets containing theophylline were coated with t...

O objetivo deste estudo foi desenvolver e avaliar as propriedades físico-químicas e a estabilidade de cremes não-iônicos (tipo O/A) contendo mel em diferentes concentrações (5, 15 e 25%, m/m). As formulações fora...

No presente trabalho foram desenvolvidas e avaliadas cinco formulações de péletes, contendo L-alanil-L-glutamina (glutamina dipeptídeo), em diferentes concentrações: F1 (9,07%); F2 (17,70%); F3 (27,98%); F4 (37,7...

The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral mucoadhesive drug delivery...