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Subjects / keywords: Technology: Chemical technology: Biotechnology; Science: Biology (General)

Subjects / keywords: biomolecular engineering, bioengineering and manufacturing, biopharmaceuticals, biomass and bioenergy; Technology: Chemical technology: Biotechnology; Science: Biology (General)

ABSTRACT Genome engineering plays a crucial role in the rapidly growing fields of metabolic engineering and synthetic biology. Chromosomal integration and stable expression of functional genes or large metabolic pathways...

Abstract One of the factors contributing to “the death valley” in biotech process transfer is an assumption that once a synthetic trait is successfully introduced and optimized in a microbial host, the resulting stra...

Abstract The in-situ upcycling of decentralized methane and nitrogen gas (N2)-derived ammonia via methanotrophic bacteria is highly attractive. However, the toxic intermediate generated from ammonia oxidation significant...

Mitragyna speciosa (commonly known as kratom) is a tropical tree native to Southeast Asia, ethnobotanically used for pain relief and fatigue management. Kratom has gained popularity in Western countries for its dose-depe...

Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional reg...

Food texture is increasingly recognized as a determinant of nutritional safety, metabolic regulation, and overall health. However, conventional approaches to texture modification rely primarily on hydrocolloids, mechanic...

Abstract Background 3-Hydroxypropionic acid (3-HP) is a promising C3 platform chemical with wide industrial applications. However, its microbial production remains limited by insufficient intracellular malonyl-CoA availa...

New emerging approaches in tissue engineering include incorporation of metal ions involved in various metabolic processes, such as Cu, Zn, Si into bioceramic scaffolds for enhanced cell growth and differentiation of spec...

In the last years, hairy root (HR) cultures are gaining attention in the biotechnology industry. This particular plant cell culture derives from explants infected with Agrobacterium rhizogenes. They constitute a relative...

Key message: Woody plants have salt-tolerant mechanisms similar to those developed by non-woody plants. Among others, compartmentalization of ions, production of compatible solutes, synthesis of specific proteins and met...

Synthetic biology is emerging as a frontier interdisciplinary discipline that is increasingly regarded as a key driver of sustainable innovation in advanced materials. By leveraging the design-build-test-learn (DBTL) cyc...

Increasing evidence links metabolic signals to cell proliferation, but the molecular wiring that connects the two core machineries remains largely unknown. E2Fs are master regulators of cellular proliferation. We have re...

Abstract One of the biggest challenges in tissue engineering and regenerative medicine is to ensure oxygen supply of cells in the (temporary) absence of vasculature. With the vision to exploit photosynthetic oxygen produ...

Phytoremediation has emerged as an attractive methodology to deal with environmental pollution, which is a serious worldwide problem. Although important advances have been made in this research field, there are still som...

In Gram-positive bacteria such a LAB, the riboflavin biosynthesis operon is regulated by FMN riboswitch. The exposure of riboflavin-producing strains to roseoflavin has been shown to cause mutations in this aptamer decre...

Abstract The plastic pollution crisis urges innovative recycling solutions. Promising approaches especially for polyester-containing wastes include enzymatic hydrolysis and microbial upcycling. For efficient enzymatic hy...

Subjects / keywords: metabolic engineering, synthetic biology, natural products, biocatalysis, environmental microbiology, fermentation; Technology: Chemical technology: Biotechnology; Science: Microbiology

Abstract The systematic exploration of novel bioactive compounds with superior functional properties is critical for driving innovations in agriculture, healthcare, and related fields, thereby becoming essential for adva...

Abstract Many sulfated polysaccharides (SPSs) possess useful physicochemical properties and biological activities and are widely used in industry. Currently, major SPSs are derived from livestock and marine organisms. To...