Neurons
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Neurons with graded response have collective computational properties like those of two-state neurons.
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A model for a large network of "neurons" with a graded response (or sigmoid input-output relation) is studied. This deterministic system has collective properties in very close correspondence with the earlier stochastic ...
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Página del recursoNeurons - Dendrites and Axons
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Material complementarioNeurons : Dendrites and Axons
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Material complementarioNeurons, Behavior, Data Analysis, and Theory
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Subjects / keywords: neuroscience, data analysis, computational neuroscience, systems neuroscience, behaviour; Science
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Open AccessCausal information quantification of prominent dynamical features of biological neurons
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Neurons tend to fire a spike when they are near a bifurcation from the resting state to spiking activity. It is a delicate balance between noise, dynamic currents and initial condition that determines the phase diagram o...
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Open AccessCutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons
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Tandem pore-domain Halothane Inhibited K+ channel (THIK1) is a two-pore-domain potassium channel (K2P) present in dorsal root ganglia (DRG). We previously demonstrated that THIK1 mRNA levels in the DRG dropped ipsilatera...
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Open AccessDysfunctional astrocytes regulate excitatory neurons via cell adhesion and vascular lesions in patients with Alzheimer’s disease
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Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Its complex pathogenesis remains unclear, and no specific drugs are available for treatment. Current treatments focus mainly on ...
LCC LCC:MedicineIdioma English
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Open AccessHistology and morphometry of dorsal root ganglia and their neurons in a fish of indeterminate growth the White Cachama (Piaractus brachypomus) HISTOLOGÍA Y MORFOMETRÍA DE LOS GANGLIOS DE LA RAÍZ DORSAL Y SUS NEURONAS EN UN PEZ DE CRECIMIENTO INDETERMINADO, CACHAMA BLANCA (PIARACTUS BRACHYPOMUS)
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A histological and morphometric analysis of the Dorsal Root Ganglia (DRGs) and their sensorial neurons were carried out to contribute to the understanding of how do their nervous system adapt to their fast body growth. T...
LCC LCC:Biology (General)Idioma English
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Open AccessPI4-kinase A is essential for survival of the GnRH neurons
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The signaling pathways that control embryonic development and migration of gonadotropin-releasing hormone (GnRH) neurons, as well as the postnatal fate and function of differentiated cells, are the subject of ongoing res...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma English
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Open AccessProtein Kinase D Regulates Trafficking of Dendritic Membrane Proteins in Developing Neurons
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In non-neuronal cells, inactivation of protein kinase D (PKD) blocks fission of trans-Golgi network (TGN) transport carriers, inducing the appearance of long tubules filled with cargo. We now report on the function of PK...
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Open AccessRotenone inhibits axonogenesis via an Lfc/RhoA/ROCK pathway in cultured hippocampal neurons
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Rotenone, a broad-spectrum insecticide, piscicide and pesticide, produces a complete and selective suppression of axonogenesis in cultured hippocampal neurons. This effect is associated with an inhibition of actin dynami...
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Open AccessTargeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons
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Abstract Background Hyperglycemia, a hallmark of diabetes mellitus, is a metabolic condition that highly affects the nervous system. While evidence from epidemiological and animal studies links diabetes to dopaminergic d...
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Material complementarioBeyond the HPA axis: Synaptic circuits of PVNCRH neurons in stress-related psychiatric disorders
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Chronic psychosocial stress is a major risk factor for anxiety, depression and related disorders, yet a hypothalamic-pituitary-adrenal (HPA) axis centric framework alone is insufficient to explain stress-induced vulnerab...
LCC LCC:Therapeutics. PharmacologyIdioma English
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Open AccessCdk5 modulates orofacial pain through P2X2/3 purinergic receptor-mediated signaling in trigeminal neurons
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IntroductionCyclin-dependent kinase 5 (Cdk5) plays a critical role in pain transmission by phosphorylating key nociceptive proteins. One of its recently identified substrates, the P2X2 subunit, is part of the P2X2/3 puri...
LCC LCC:Therapeutics. PharmacologyIdioma English
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Open AccessCross-talk between microglia and neurons regulates HIV latency.
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Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) are found in nearly one-third of patients. Using a cellular co-culture system including neurons and human microglia infected ...
LCC LCC:Immunologic diseases. Allergy; LCC:Biology (General)Idioma English
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Material complementarioDifferent inoculum loads of Toxoplasma gondii induce reduction of myenteric neurons of the rat colon
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Different inoculum loads of Toxoplasma gondii induce reduction of myenteric neurons of the rat colon
Abstract Toxoplasmosis, a disease caused by Toxoplasma gondii, is an important health problem, especially in immunocompromised hosts. T. gondii uses the gut wall as an infection gateway, with tropism for muscular and ner...
LCC LCC:Animal cultureIdioma English
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Open AccessDifferential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress.
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Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pathways including autophagy, proteasome-mediated degradation, antioxidant defense, nutrie...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma English
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Open AccessDopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward
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Abstract Classic theories propose opponent functions for striatal dopamine (DA) and serotonin (5-hydroxytryptamine; 5HT), with DA promoting approach and 5HT promoting patience or avoidance. How these neuromodulators regu...
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Open AccessEpistemological evaluation of evidence for ‘number’ neurons in the parietal cortex of macaque monkeys
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A contemporary theory holds that mathematical concepts are stored in the long-term memory of mathematicians. This perspective also proposes that the brain has evolved to possess basic “representations” of space, time...
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Open AccessIslet-1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood
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Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates. These neurons release POMC-encode...
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Open AccessIsoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β–TFEB signaling axisAll raw data for the paper can be downloaded via the WeTransfer link.
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Lysosomal dysfunction is a core pathological driver of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Transcription factor EB (TFEB) serves as a master regulator of lysosomal biogenesis, and its ...
LCC LCC:Therapeutics. PharmacologyIdioma English
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Open AccessLidocaine protects neurons of the spinal cord in an excitotoxicity model
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Motor Neuron Disease disorders, described in domestic animals, are characterized by neuronal degeneration at the spinal cord. Excitotoxicity is a crucial factor for the selective loss of these neurons, being the fundamen...
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Open AccessMorphometric and quantitative characterization of atrial ganglion neurons from the intercaval region in dogs with dilated cardiomyopathy Caracterização morfométrica e quantitativa dos neurônios ganglionares atriais da faixa intercaval de cães com cardiomiopatia dilatada
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The quantity, morphometry, and quality of atrial neurons from the intercaval region in dogs with dilated cardiomyopathy (DCM) were evaluated. Dogs with DCM had greater ganglion neurons than control dogs. The histologic e...
LCC LCC:Animal cultureIdioma English
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