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Abstract One of the factors contributing to “the death valley” in biotech process transfer is an assumption that once a synthetic trait is successfully introduced and optimized in a microbial host, the resulting stra...

BackgroundCurrent prognostic models for cerebral venous sinus thrombosis (CVST) inadequately predict long-term cognitive and functional outcomes, focusing primarily on survival. We aimed to develop and validate a simple,...

Plant phenotyping links genomics with plant ecophysiology and agronomy. It is usually performed by non-destructive, automated and image-based technology and generates information for efficient and searchable digital char...

IntroductionTiller production is a critical determinant of turfgrass canopy density and plant performance, yet manual tiller counting is too labor-intensive for large breeding programs.MethodsTo address this limitation, ...

The objective of this work was to evaluate 81 lentil cultivars using morphological traits and seed characteristics using digital phenotyping. Caliber (C) and the color traits luminosity (L), color coordinates a and b, an...

Abstract BackgroundDigital behaviors such as sleep, social interactions, and productivity reflect how individuals structure their daily lives. Among university students, online activity patterns mirror academ...

The variability of raw wool traits over fleeces is still poorly known. We conducted a 2-year field study on 10 Corriedale ewes aimed at characterizing the spatial distribution of fibre diameter (FD) and staple length (SL...

Abstract Background Eating behaviors are shaped by contextual factors such as where people eat, who they eat with, and their activities and mood during meals. However, data on these determinants of food choice in Asian p...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open re...

Morphological phenotyping of genetically engineered or experimentally challenged mice is the first step in researching the causality of congenital malformations. Especially for spatially complex structures like the inner...

Estimating three-dimensional morphological traits such as volume from two-dimensional RGB images presents inherent challenges due to the loss of depth information, projection distortions, and occlusions under field condi...

IntroductionHyperuricemia, pulmonary hypertension, renal failure, alkalosis (HUPRA) syndrome is a mitochondrial disease caused by mutations in SARS2 (seryl-tRNA synthetase 2), which plays a role in protein synthesis. Lim...

IntroductionThe T cell receptor excision circle (TREC) assay is an effective neonatal screening tool for severe combined immunodeficiency (SCID), enabling early diagnosis and timely intervention. While genetic analysis o...

Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...

Abstract Background Glanzmann's thrombasthenia (GT) is a congenital platelet disorder affecting approximately 1:1 000 000 people globally and characterized by impaired platelet aggregation and clot retraction. Autoso...

Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

The agricultural sector contributes significantly to the economic development of nations worldwide. Owing to the population explosion, agriculture must address the complex challenges to meet the growing food demand while...

Aim: The aim of this study was to evaluate clinical and polysomnographic differences in sleep architecture between patients with chronic insomnia (CI) and healthy controls (HC), as well as between CI phenotypes with shor...

BackgroundThe use of antibiotics may influence the efficacy and toxicity of immune checkpoint inhibitors (ICIs) by altering the gut microbiota. However, current evidence on the link between antibiotic use and immune-rela...

The article presents the developed algorithm and software for automated monitoring of strawberry plant growth using neural network technologies. The YOLO11x and YOLOx-seg models, pre-trained by transfer learning, are ada...

Abstract We developed and evaluated a deep learning system integrating segmentation and classification for automated detection of Weiss rings on fundus photographs (FPs). A U-Net segmenter and two EfficientNet-B0 classif...

Mitochondria orchestrate energy conversion and cell fate, yet label-free approaches that report both functional and physical states at the single-organelle level are nonexistent. Here, we combine atomic force microscopy ...

Abstract Conventional immunotoxicological approaches are often insufficient to comprehensively elucidate the complex immune responses that may arise during the degradation, metabolite generation, and tissue integration o...