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Abstract Background The chromogenic anti‐Xa assay, the gold standard for monitoring the anti‐Xa effect of rivaroxaban, is not available as a cage‐side diagnostic test for use in a clinical setting. Hypothesis/Objec...

Clinical narratives in electronic health records (EHRs) are a key source of information in mental health care, but their unstructured nature limits systematic analysis. We propose an NLP framework to extract therapeutic ...

ObjectivesAlthough therapeutic drug monitoring (TDM) for isavuconazole (ISA) is not routinely recommended, its utility in specific populations remains debated. This study aimed to elucidate the need for ISA TDM and to id...

Depression during pregnancy is common worldwide, with higher prevalences in low-income countries compared to high-income countries. Yet, current antidepressant dosing strategies in pregnant patients rarely account for th...

Abstract Background The majority of dogs with coccidioidomycosis recover with administration of fluconazole or itraconazole, although some cases are refractory or the dogs do not tolerate administration of these medicati...

Abstract Background Established treatment protocols for schistosomiasis (Heterobilharzia americana) in dogs are expensive. Anecdotal reports suggest that lower doses of praziquantel, combined with fenbendazole, may elimi...

Abstract This study evaluated dynamics of antibodies in dogs treated for canine visceral leishmaniasis (CVL). Twenty-one dogs naturally infected by Leishmania spp. were grouped based on the treatment protocol: G1 (n=4) r...

Abstract Background Neurofilament light chain (NfL) is a frequently used biomarker in humans for both diagnostic and therapeutic monitoring purposes in various neurologic diseases. Hypothesis/Objectives It was hypothesiz...

Interferonopathies are rare autoinflammatory disorders driven by a constitutive upregulation of the type I interferon (IFN-I) pathway, leading to chronic activation of this cytokine. Despite advances, direct IFN-I measur...

Patients with STAT1 gain-of-function (GOF) variants may present not only with chronic mucocutaneous candidiasis and other forms of immunodeficiency but also with a broad-spectrum of autoimmune manifestations, for which J...

Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....

Innovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel ...

Monitoring drug release in vitro and in vivo is of paramount importance to accurately locate diseased tissues, avoid inappropriate drug dosage, and improve therapeutic efficiency. In this regard, it is promising to devel...

Abstract Diabetes mellitus represents one of the most prevalent chronic diseases worldwide, posing serious challenges to global health and healthcare sustainability. Conventional therapeutic strategies often face limitat...

Combined diquat and paraquat poisoning is a rare but clinically significant form of poisoning, associated with severe oxidative stress and multiorgan failure. Historical case series have reported high case fatality, part...

Actinic keratosis is a common skin condition that has the potential to develop into malignant neoplastic lesions. Factors that are known to increase the likelihood of developing actinic keratosis include older age, male ...

Immune checkpoint inhibitors (ICIs) have been game changer in cancer therapy but can trigger diverse immune-related adverse events (irAEs) that impact multiple organs. This review offers a unified perspective on irAE ris...

Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability worldwide. Endovascular mechanical thrombectomy (EVT) has revolutionized stroke treatment by enabling rapid recanalization of occl...

Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...

BackgroundValproic acid (VPA) is widely used in pediatric epilepsy, but its blood concentrations vary considerably among pediatric patients with epilepsy. This study aimed to investigate the factors influencing VPA blood...

Background: Therapeutic drug monitoring facilitates the individualiza­tion of amikacin dosing for patients based on pharmacodynamics and pharmacokinetics. Its efficacy is measured by peak serum concentration (Cpeak) / m...

Abstract Background In purpose‐bred dogs, insulin glargine 300 U/mL (IGla300) has long duration of action, peakless time‐action profile, and low potency, making it suitable for use as a basal insulin. Hypothesis To...

Abstract Background Musculoskeletal diseases, such as Juvenile Idiopathic Arthritis (JIA), can lead to altered joint mobility and changes in gait pattern. While marker-based motion capture systems are considered the gold...