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Introduction. Acroosteolysis is a recognized, but under-researched and forgotten manifestation of systemic sclerosis (SSc). Objective . To present a case of exuberant acroosteolysis and subcutaneous tissue calcinosi...

Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants,...

Introduction. Human papillomaviruses (HPV) consist of more than 120 subtypes of viruses, which can be divided into three main groups: skin subtypes, mucosal subtypes and types responsible for the occurrence of the skin...

Antimalarial drugs used in medicine for over 300 years, nowadays, due to their anti-inflammatory, immunomodulatory and antiproliferative photoprotective properties, are used in the therapy of many dermatologic and rheuma...

Atopic dermatitis is a frequent, chronic and recurrent inflammatory skin disease with complex etiology. Typical symptoms of this disease are persistent itching and dry skin. To assess the severity of the disease we use v...

Azelaic acid (AZA) is a naturally occurring substance produced by Malassezia furfur which exerts various effects on the skin. Azelaic acid has antibacterial, anti-inflammatory, keratolytic, comedolytic, sebostatic and ty...

Introduction . Bed bugs belong to the family Cimicidae, which includes two cosmopolitan species: Cimex lectularius and Cimex hemipterus. Bed bugs feed on the blood of humans and animals. As a result of bites, skin change...

Lichen sclerosus (LS) is a chronic inflammatory disease of the skin and mucous membranes, which usually involves the genitals and anus. All patients with itchy symptoms from genitals or atrophic lesions, as well as indur...

Introduction . Cutaneous leiomyomas are rare, benign smooth muscle neoplasms of the skin. According to the origin of the tumor, there are three types of cutaneous leiomyomas: piloleiomyomas, angioleiomyomas and genital l...

Introduction. Autoimmune polyglandular syndrome type 1 (APS-1) is a type of polyendocrinopathy, inherited in an autosomal recessive manner. Beside the classic triad of symptoms (candidiasis of the skin and mucous membr...

Dermoscopy is currently the standard method for clinical differential diagnosis of cutaneous melanoma and for qualifying a lesion for excisional biopsy. Full thickness excisional biopsy of suspicious melanomatous skin le...

Dapsone has been used in the treatment of bullous pemphigoid (BP) for over 50 years. According to the 2015 European Recommendations, the treatment of choice in BP are potent topical corticosteroids. In this article, we p...

Introduction . Dermatitis herpetiformis is a rare bullous disorder. Autoimmunological disturbances associated with hypersensitivity to gluten play the main role in the etiopathogenesis of the disease. Clinical manifestat...

Chemotherapeutic agents and drugs used for targeted tumor therapy often cause undesirable side effects of the skin which typically are toxic cutaneous reactions (toxicity grade 1 to 4). The first group of drugs that caus...

It is a generally accepted principle that the skin is a mirror of human health. Also neurological conditions may be accompanied by characteristic skin changes of significant diagnostic value. Careful and precise examinat...

Introduction . Dermatomyositis is a rare systemic disease of connective tissue characterized by inflammation of the muscles and the skin. Malignant melanoma is a cancer that begins in melanocytes in the skin, mucosa of t...

Dermatitis herpetiformis (Duhring’s disease) is an autoimmune blistering dermatosis with a characteristic polymorphic, itchy rash. The autoimmune process against transglutaminases (TGs) is connected with asymptomatic o...

Introduction . Autoimmune blistering diseases are mediated by autoantibodies directed against structural proteins of the skin. Pemphigus vulgaris (PV) is the most common type of pemphigus. The main auto-antigen in PV is ...

Introduction. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a serious, potentially life-threatening syndrome with skin lesions, internal organ involvement and eosinophilia. Objective . To present th...

The large surface area of the skin, high metabolism and location at the border of two environments (external and internal) cause continuous production of free radicals within the skin. There are two mechanisms of skin ph...

Introduction . Formaldehyde is a noxious gas used as a tissue preservative of cadavers in autopsy rooms. Therefore, exposure to higher concentrations applies particularly to laboratory staff, anatomists and medical stude...