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Abstract Ovarian cancer (OC) ranks among the most aggressive malignancies of the female reproductive system. The immunosuppressive tumor microenvironment (TME) and pronounced spatial heterogeneity significantly restrict ...

Abstract Transcriptome sequencing data offer a valuable resource for inferring genetic variants, yet their application in forensic individual identification and kinship analysis remains insufficiently explored. This stud...

Abstract The molecular control and ancestral state of dorsal–ventral patterning within spiralians remain unclear due to the remarkable diversity across species. Here we present a chromosome-level genome for the brachio...

Abstract Background Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. Objectives Define region...

Plasmodiophora brassicae, the obligate parasite responsible for clubroot in Brassica crops and other crucifers, poses a major challenge to sustainable disease management due to its biotrophic lifestyle and adaptability. ...

Monascus pigments (MPs) are important azaphilone-type polyketide pigments, yet yield control, stability, and safety pose challenges. Using an epigenetic derepression strategy, we constructed an Ash2 deletion mutant in th...

Heat Shock Proteins (HSPs) are a superfamily of chaperones that have been characterized in different organisms. In plants, HSPs promote protein folding and deaggregation during abiotic stress or developmental changes. Th...

Abstract Objective Retinal neovascularization is a leading cause of irreversible blindness worldwide. Chinese herbal medicines have unique therapeutic properties, such as antioxidant, anti-inflammatory, and neuroprotecti...

Abstract Background Lung adenocarcinoma (LUAD) is a predominant contributor to cancer‑related mortality globally. Lung‑associated fibroblasts (LAFs) are intricately linked to tumorigenesis and the tumor microenvironm...

ABSTRACT Autosomal recessive polycystic kidney disease (ARPKD) leads to severe renal cysts and progressive kidney dysfunction, with no approved treatments. The absence of such cystic phenotypes in Pkhd1−/− mice under...

T follicular helper (Tfh) cells have been reported to have multiple trajectories, including terminally differentiated Tfh, memory-like circulatory Tfh (cTfh), and, most recently, induced T follicular regulatory (iTfr) ce...

Abstract Background The floral transition in maize represents a pivotal developmental switch that determines flowering time, environmental adaptation, and yield-related traits. However, the molecular mechanisms governing...

Abstract Myasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in...

Abstract Background Phenotypic switching of vascular smooth muscle cells (VSMCs) is a hallmark of coronary artery disease (CAD). How type 2 diabetes mellitus (T2DM), a major risk factor for cardiovascular complications, ...

Danyang Yang,1 Xin Liu,1 Wenwen Jing,1 Xu Feng,1 Canying Lai,1 Chenyue Liu,2 Zhigang Xu,1,3 Yangang Zhang,1 Jiayi Han,1 Songmei Geng,1 Ruilian Li,1 Dan Li,4 Boyi Cheng,1 Yufei Wu,1 Zhuokun Liu,1 Jialin Lian,1 Zhenghui Wa...

Abstract Alcoholic Heart Disease (AHD) involves gut microbiota dysbiosis, metabolic disturbances, and circadian disruption, yet their interconnections remain unclear. Using a murine AHD model, we integrated echocardiogra...

Background: In multiple sclerosis (MS), chronic “smoldering” lesions are driven by microglial activation, which promotes demyelination and disease progression. However, microglia exhibit a functional dichotomy by per...

Abstract Background Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified s...

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by aberrant immune responses and tissue remodeling. Ligustrazine has multiple effects, such as enh...

ABSTRACT The cGAS‐STING pathway is emerging as an essential driver in systemic lupus erythematosus (SLE). Here, we characterize the key signature of cGAS‐STING pathway and its roles in SLE by leveraging large‐scale...

Transient hypoxia in pregnancy stimulates a physiological reflex response that redistributes blood flow and defends oxygen delivery to the fetal brain. We designed the present experiment to test the hypotheses that trans...

IntroductionDNGR-1 (CLEC9A), a C-type lectin receptor specifically expressed on human BDCA3+ and murine CD8α+/CD103+ conventional type 1 dendritic cells (cDC1), acts as a damage-associated molecular pattern (DAMP) recep...

The development of ectomycorrhizal (ECM) symbioses between soil fungi and tree roots requires modification of root cell walls. The pectin-mediated adhesion between adjacent root cells loosens to accommodate fungal hyphae...

Background Postmenopausal osteoporosis (PMOP) is characterized by exacerbated bone resorption and inadequate bone formation, with macrophage-driven inflammation playing a key role. However, how immunometabolic reprogramm...