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ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regula...

Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

The aluminum alloys D16 and AMg6 were irradiated using the high-current relativistic electron beam in vacuum. Intense electron irradiation of the materials modified their physical properties. The fractal character of the...

A method for the polymerization modification of nanoscale fumed silica by crosslinking a lignin layer adsorbed on a nanosilica surface under a gas dispersion medium is described. A mixture of phenol and formaldehyde in t...

Approximately 670 million residents in the ASEAN region face heat-related health risks including synergistic effects with air pollution. Despite health impacts of heat studies existed in individual countries, a regionwid...

To address the challenges of membrane fouling, short service life, and unstable performance associated with PVDF membranes in wastewater treatment and reuse, this study proposes a multi-dimensional collaborative optimiza...

Abstract Gears are important mechanical parts for transmitting power and play an increasingly important role in the machinery industry. The electric vehicle industry developed rapidly and became a vital development field...

Abstract Background Witches’ broom is an important disease of the Paulownia fortunei. Understanding the pathogenesis of witches’ broom is a prerequisite for its prevention and control. Phytoplasma is the pathogen of ...

Reconstructing the faunal palaeoecology of landscapes occupied by Neanderthals and their competitors is essential for better understanding their ecological niche, decisions, and behaviors. Late Pleistocene faunal assembl...

Lignin, the most abundant aromatic polymer from nature, represents a promising feedstock for sustainable functional materials. Yet its intrinsic structural heterogeneity and broad molecular weight distribution limit its ...

Currently, laser-induced structural modifications in optical materials have been an active field of research. In this paper, we reported structural modifications in the bulk of sapphire due to picosecond (ps) laser filam...

ABSTRACT Background Hyperesthesia syndrome (HS) is a common yet poorly understood condition in cats, with hypothesized neurological and behavioral causes and limited data on outcomes and treatment. Objectives This study ...

Abstract Background Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now r...

S-palmitoylation, a key reversible lipid post-translational modification, entails the covalent conjugation of palmitic acid chains to the thiol groups of cysteine residues in proteins. This modification modulates protein...

Biological reactions occur in a highly organized spatiotemporal context and with kinetics that are modulated by multiple environmental factors. To integrate these variables in our experimental investigations of 'native' ...

Abstract Fungal histone methylation modification (HMM) includes methylation and demethylation at the histone lysine/arginine residues, which are catalyzed by the methyltransferases (HMTs) and demethylases (HDMs) of histo...

ObjectiveThe cycloid gear is a core component of the RV reducer, and its high-efficiency and precision machining methods are crucial for ensuring the performance of the reducer. In view of this, the basic principle metho...

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone ...

Abstract Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical ...

Abstract Cutting fluid is crucial in ensuring surface quality and machining accuracy during machining. However, traditional mineral oil-based cutting fluids no longer meet modern machining’s health and environmental pr...

Abstract Mediterraneibacter gnavus is a human symbiotic gut bacterium whose abundance often increases in patients with various diseases, such as active inflammatory bowel disease (IBD). However, the genetic factors gover...

Controlling the construction of physical colors on the surfaces of transparent dielectric crystals is crucial for surface coloration and anti-counterfeiting applications. In this study, we present a novel approach to cre...

Elucidation of the cellular functions of RNAs represents one of the most exciting research areas in modern life sciences. RNAs play crucial roles in plant biology, including developmental regulation and environmental res...